Lifeboat Foundation

To answer the iconic question “Are We Alone?”, scientists around the world are also attempting to understand the origin of life. There are many pieces to the puzzle of how life began and many ways to put them together into a big picture. Some of the pieces are firmly established by the laws of chemistry and physics. Others are conjectures about what Earth was like four billion years ago, based on extrapolations of what we know from observing Earth today. However, there are still major gaps in our knowledge and these are necessarily filled in by best guesses.

We invited talented scientists to discuss their different opinions about the origin of life and the site of life’s origin. Most of them will agree that liquid water was necessary, but if we had a time machine and went back in time, would we find life first in a hydrothermal submarine setting in sea water or a fresh water site associated with emerging land masses?

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Peter voss is a serial entrepreneur, engineer, inventor and a pioneer in artificial intelligence.

Peter started out in electronics engineering but quickly moved into software. After developing a comprehensive ERP software package, Peter took his first software company from a zero to 400-person IPO in seven years.

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In the past 24 hours, a story of potentially world-changing import has surfaced. First reported by the MIT Technology Review and then not long after by the Associated Press, who seem to have been sitting on the story for a while, the news that a Chinese scientist named He Jiankui led an unprecedented experiment to edit human embryos and see them carried to term rocked the genetics community. Here’s what you need to know about this evolving story.

The science

Besides He, the most important players in this story may be twin baby girls named Nana and Lulu. As far as we know the twins were edited as embryos using CRISPR-cas9, a gene editing tool. The stated purpose of the edit was to disable CCR5, a gene involved in allowing HIV to invade cells, which is how a virus infects a host.

Continue reading “Scientists ‘went rogue’ and genetically engineered two human babies—or at least claimed to” »

Researchers may have demonstrated a novel way to protect us from some of the world’s deadliest viruses. By genetically engineering immune cells to make more effective antibodies, they have defended mice from a potentially lethal lung virus. The same strategy could work in humans against diseases for which there are no vaccines.

“It’s a huge breakthrough,” says immunologist James Voss of the Scripps Research Institute in San Diego, California, who wasn’t connected to the study.

Vaccines typically contain a disabled microbial invader or shards of its molecules. They stimulate immune cells known as B cells to crank out antibodies that target the pathogen. Not everyone who receives a vaccine gains protection, however. Some patients’ antibodies aren’t up to snuff, for instance. And researchers haven’t been able to develop vaccines against some microbes, such as HIV and the respiratory syncytial virus (RSV), which causes lung infections mainly in children and people with impaired immune systems.

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But they don’t. Instead, they are less likely to develop or die of this enigmatic disease. The same is true of elephants and dinosaurs’ living relatives, birds. Marc Tollis, an assistant professor in the School of Informatics, Computing, and Cyber Systems at Northern Arizona University, wants to know why.

Tollis led a team of scientists from Arizona State University, the University of Groningen in the Netherlands, the Center for Coastal Studies in Massachusetts and nine other institutions worldwide to study potential cancer suppression mechanisms in cetaceans, the mammalian group that includes whales, dolphins and porpoises. Their findings, which picked apart the genome of the humpback whale, as well as the genomes of nine other cetaceans, in order to determine how their cancer defenses are so effective, were published today in Molecular Biology and Evolution.

The study is the first major contribution from the newly formed Arizona Cancer and Evolution Center or ACE, directed by Carlo Maley under an $8.5 million award from the National Cancer Institute. Maley, an evolutionary biologist, is a researcher at ASU’s Biodesign Virginia G. Piper Center for Personalized Diagnostics and professor in the School of Life Sciences. He is a senior co-author of the new study.

Continue reading “How whales defy the cancer odds: Good genes” »

There’s no doubt that genetic therapy won’t be cheap.

An all-Princeton research team has identified bacteria that can detect the speed of flowing fluids.

Many kinds of cells can sense flow, just as our skin cells can feel the difference between a gentle breeze and a strong wind. But we depend on feeling the force involved, the push-back from the air against us. Without that push, we can’t distinguish speed; when the windows are closed, our skin can’t feel any difference in air force whether we are sitting in an office, a speeding car or a cruising airplane. But now, a team of Princeton researchers has now discovered that some bacteria can in fact detect the speed of flow regardless of the force. Their paper appears in the online journal Nature Microbiology.

“We have engineered bacteria to be speedometers,” said Zemer Gitai, Princeton’s Edwin Grant Conklin Professor of Biology and the senior author on the paper. “There’s an application here: We can actually use these bacteria as flow sensors. If you wanted to know the speed of something in real time, we can tell you.”

Continue reading “Scientists bioengineer a cellular speedometer” »

Australia has approved the use of CRISPR gene editing tool on plants and animals without the oversight of a governmental body. The controversial move has been called a ‘middle ground’ compared to regulations on other countries.