Archive for the ‘bioengineering’ category: Page 17

Feb 13, 2020

CRISPR causes greater genetic damage than previously thought

Posted by in categories: bioengineering, biotech/medical, food, genetics

Caution required for using CRISPR in potential gene therapies – and food plants

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells. Potential consequences could include triggering cancer.

Reported on 16 July 2018 in the journal Nature Biotechnology, the study also revealed that standard tests for detecting DNA changes miss finding this genetic damage, and that caution and specific testing will be required for any potential gene therapies.

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Feb 12, 2020

Designer probiotic treatment for cancer immunotherapy

Posted by in categories: bioengineering, biotech/medical

Researchers at Columbia Engineering have engineered probiotics to safely deliver immunotherapies within tumors. These include nanobodies against two proven therapeutic targets—PD-L1 and CTLA-4. The drugs are continuously released by bacteria and continue to attack the tumor after just one dose, facilitating an immune response that ultimately results in tumor regression. The versatile probiotic platform can also be used to deliver multiple immunotherapies simultaneously, enabling the release of effective therapeutic combinations within the tumor for more difficult-to-treat cancers like colorectal cancer. The study is published today in Science Translational Medicine.

Antibodies that target immune checkpoints, PD-L1 and CTLA-4, have revolutionized immunotherapy treatments, achieving success in a subset of cancers. However, systemic delivery of these antibodies can also cause substantial side effects with high percentages of patients reporting adverse reactions. Furthermore, although combinations of these therapies are more effective than single therapy regimens, they also produce severe toxicities, sometimes leading to drug discontinuation. The team, led by Tal Danino, assistant professor of biomedical engineering, aimed to address these challenges.

“We wanted to engineer a safe probiotic vehicle capable of delivering immune checkpoint therapies locally to minimize side effects,” says Danino, who is also a member of the Herbert Irving Comprehensive Cancer Center and Data Science Institute. “We also wanted to broaden the versatility of the system by producing a range of immunotherapeutic combinations, including cytokines that could further elicit antitumor immunity, but are otherwise difficult to systemically deliver because of toxicity concerns.”

Feb 12, 2020

Following the first U.S. test of CRISPR gene editing in patients with advanced cancer

Posted by in categories: bioengineering, biotech/medical

Following the first U.S. test of CRISPR gene editing in patients with advanced cancer, researchers report findings in Science that represent an important step toward the ultimate goal of using gene editing to help a patient’s immune system attack cancer. Read the research: https://fcld.ly/y1nst2o

Feb 8, 2020

Ireland — World’s First “Age Friendly” Country by World Health Organization (WHO) Network — Catherine McGuigan, National Program Lead, Age Friendly Ireland — ideaXme — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, economics, finance, genetics, geopolitics, governance, health, life extension

Feb 7, 2020

Embrace human genome editing

Posted by in categories: bioengineering, biotech/medical, genetics, government, neuroscience, time travel

Imagine then, the emancipatory potential of genome editing for these millions.

Realizing this potential, however, will require that genome editing meet with societal approval. The typical response right now when you talk to someone about genetic engineering or reproductive technology is a reference to ‘designer babies,’ eugenics, Nazism, and other evils. These arguments have a very powerful emotional hold over many people, but in my opinion, they simply don’t stand up to scrutiny.

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Feb 5, 2020

Scientists Release Genetically Engineered Moths for First Time

Posted by in categories: bioengineering, biotech/medical, food, genetics, sustainability

The diamondback moth is a huge pest. It eats a variety of crops, but is largely resistant to insecticides, resulting in upwards of $5 billion in losses every year.

That could soon change, though, as an international team of researchers has created a strain of genetically engineered diamondback moths that could suppress the pest population in a sustainable way — and they just released them into the wild for the first time.

For the study, published Wednesday in the journal Frontiers in Bioengineering and Biotechnology, the researchers engineered the moths so that when the males of the strain mated with wild females, the female offspring would die during the caterpillar life stage.

Feb 5, 2020

Step aside CRISPR, RNA editing is taking off

Posted by in categories: bioengineering, biotech/medical, genetics

But CRISPR editing — at least as a therapeutic technique in people — has turned out to be more difficult than initially thought. Researchers have documented ways that Cas9, one of the enzymes used in CRISPR gene editing, could trigger immune responses, or cause accidental changes to the genome that would be permanent. RNA editing, by contrast, could allow clinicians to make temporary fixes that eliminate mutations in proteins, halt their production or change the way that they work in specific organs and tissues. Because cells quickly degrade unused RNAs, any errors introduced by a therapy would be washed out, rather than staying with a person forever.

Making changes to the molecular messengers that create proteins might offer flexible therapies for cancer, pain or high cholesterol, in addition to genetic disorders.

Feb 3, 2020

DR STEPHEN BADYLAK — Regen Med Strategies for Tissue & Organ Replacement (Long Version)

Posted by in categories: bioengineering, biotech/medical, life extension

Regenerative medicine and furthermore tissue engineering are realities for some time but well hidden from the public by msm somehow.

Dr. Stephen Badylak, Director of the Center for Pre-Clinical Tissue Engineering, McGowan Institute for Regenerative Medicine.

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Feb 2, 2020

Scientists Want to Explore Ocean With “Cyborg Jellyfish”

Posted by in categories: bioengineering, cyborgs

In a trial, the scientists were capable of using electrical jolts from microelectronic controllers to make jellyfish swim not only faster but also more efficiently, according to a paper published in Science Advances today.

“We’ve shown that they’re capable of moving much faster than they normally do, without an undue cost on their metabolism,” said co-author and Stanford bioengineering PhD candidate Nicole Xu, in a statement.

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Feb 2, 2020

How one entrepreneur is tackling humanity’s most pressing problems

Posted by in categories: bioengineering, computing, internet, neuroscience, particle physics

Braintree founder Bryan Johnson, MBA’07, invests in bold ventures on the next frontier.

Bryan Johnson is determined to explore the depths of your mind and help save humanity from its direst threats.

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