Archive for the ‘bioengineering’ category: Page 2

Dec 20, 2023

From Blacksmiths to Beamlines: 3D Atomic Revelations Transform Alloy Engineering

Posted by in categories: bioengineering, mapping, transportation

UCLA breaks new ground in alloy research, presenting the first 3D mapping of medium and high-entropy alloys, potentially revolutionizing the field with enhanced toughness and flexibility in these materials.

Alloys, which are materials such as steel that are made by combining two or more metallic elements, are among the underpinnings of contemporary life. They are essential for buildings, transportation, appliances and tools — including, very likely, the device you are using to read this story. In applying alloys, engineers have faced an age-old trade-off common in most materials: Alloys that are hard tend to be brittle and break under strain, while those that are flexible under strain tend to dent easily.

Advancements in Alloy Research.

Dec 20, 2023

Revolutionizing Biology: USC’s Breakthrough in “CReATiNG” Synthetic Chromosomes

Posted by in categories: bioengineering, biotech/medical, genetics, space travel

USC Dornsife’s CReATiNG technique revolutionizes synthetic biology by facilitating the cost-effective construction of synthetic chromosomes, promising significant advancements in various scientific and medical fields.

A groundbreaking new technique invented by researchers at the USC Dornsife College of Letters, Arts and Science may revolutionize the field of synthetic biology. Known as CReATiNG (Cloning Reprogramming and Assembling Tiled Natural Genomic DNA), the method offers a simpler and more cost-effective approach to constructing synthetic chromosomes. It could significantly advance genetic engineering and enable a wide range of advances in medicine, biotechnology, biofuel production, and even space exploration.

Simplifying Chromosome Construction

Dec 19, 2023

Vertex Pharmaceuticals

Posted by in categories: bioengineering, biotech/medical

Our research at Vertex is built upon two strong pillars: biology and therapeutic innovation. We continue to fill our drug discovery toolbox with cutting-edge tools and technologies. One of these tools is CRISPR/Cas9 gene editing. Watch this video to learn about how CRISPR/Cas9 gene editing works and how it can be used in therapeutic development.\

For company updates and to learn more about Vertex Pharmaceuticals, follow us on Twitter (/ vertexpharma, YouTube (/ @vertexpharmaceuticalsglobal) and LinkedIn (/ vertex-pharmaceuticals, or visit our website at www.vrtx.com.

Dec 16, 2023

Vertex’s First Crispr Gene Editing Therapy Gets EU Backing

Posted by in categories: bioengineering, biotech/medical, genetics, health

Europe’s health regulator followed the US and UK in backing the first gene-editing therapy to use Crispr technology, a Vertex Pharmaceuticals Inc. and Crispr Therapeutics AG treatment for sickle cell disease.

The European Medicines Agency’s expert panel recommended on Friday authorizing the Vertex and Crispr drug, Casgevy, for people with severe sickle cell disease and another serious hereditary blood disorder, beta-thalassemia, which is traditionally treated with repeated transfusions. Vertex said before the ruling that it had yet to establish a European list price for the one-time therapy, which costs $2.2 million in the US.

The treatment makes precisely targeted changes in patients’ DNA, a months-long process that requires removing bone marrow and a stem cell transplant. In Europe, Vertex said its initial focus will be on countries with the highest numbers of patients, including France, Italy, the UK and Germany.

Dec 14, 2023

Kinematic self-replication in reconfigurable organisms

Posted by in categories: bioengineering, genetics, robotics/AI

All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized.

Dec 14, 2023

Why gene editing technology may change the future of medicine

Posted by in categories: bioengineering, biotech/medical

Newly approved CRISPR treatment can change a person’s “blueprint.”

Dec 14, 2023

Scientists craft embryo model mimicking early human blood development

Posted by in categories: bioengineering, biotech/medical

The model can help evolve “better methods for growing cells for blood transfusions, novel cell therapies, and hematopoietic stem cell transplants.”

Remarkably, heX-Embryoid models developed structures akin to blood islands, the initial sites supporting the generation of blood cells in developing embryos. The study identified progenitors for red blood cells, platelets, and various white blood cell types—a pivotal advancement in the field, according to the team.

Researchers claim the model successfully replicated a process closely resembling the initial stages of blood production in humans. “This is exciting because there are extensive possibilities to apply this model to better understand how blood is formed and develop better methods for growing cells for blood transfusions, novel cell therapies, and hematopoietic stem cell transplants,” said Mo Ebrahimkhani, senior author and an associate professor at the Pittsburgh Liver Institute and the Department of Bioengineering at Pitt, in a statement.

Continue reading “Scientists craft embryo model mimicking early human blood development” »

Dec 13, 2023

Can gene editing drive out HIV and hepatitis viruses from inside cells?

Posted by in categories: bioengineering, biotech/medical, genetics

Armed with gene technologies and CAR-Ts, scientists are attempting to eliminate viruses that escape immune detection and lurk in tissues for years.

Dec 12, 2023

CRSP Stock On Wild Ride After FDA’s Historic Approval. These Gene Editing Treatments Could Be Next

Posted by in categories: bioengineering, biotech/medical

Biotech stocks could be at a major turning point after FDA approval of the first gene editing drug using CRISPR technology to treat sickle cell disease. Gove…

Dec 10, 2023

Gene editing gone wrong: Scientists accidentally create angry hamsters

Posted by in categories: bioengineering, biotech/medical, genetics

A team of scientists used gene editing to create what they thought would be a calmer rodent. Instead, the gene-edited rodents were angrier.

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