Lifeboat Foundation: Safeguarding Humanity
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Category: bioengineering – Page 212

Scientists are one step closer to using CRISPR gene editing on humans, with a US federal advisory panel approving the use of the technique for a study led by the University of Pennsylvania.

The scientists are seeking to use the CRISPR-Cas9 technique to create genetically altered T cells – white blood cells that play an important role in our immune system – that are more effective at fighting cancer cells in patients with melanoma, multiple myeloma, and sarcoma.

“Our preliminary data suggests that we could improve the efficacy of these T cells if we use CRISPR,” lead researcher Carl June told the National Institute of Health’s (NIH) Recombinant DNA Advisory Committee (RAC) on Tuesday.

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Always a trickle down effect on things that improve or change. Just reconfirms and reminds us organically how everything is indeed connected.

Capital tends to have greater value the more skilled and educated the workforce. Anticipating genetically enhanced workers would cause firms to want to invest more now in new equipment and buildings. Many assets, such as real estate and intellectual property, become more valuable the richer a society and so expectations of a much higher economic growth rate would cause companies to spend more buying and developing these assets so that businesses, as well as governments, will wish to borrow more when they realize the potential of human genetic engineering.

Many individuals will reduce their savings rate in anticipation of a future richer society. Today, fear that Social Security won’t survive motivates many Americans to save, but this fear and so this incentive for saving would disappear once genetic engineering for intelligence proves feasible. Furthermore, many citizens would rationally expect future government benefits to senior citizens to increase in a world made richer by genetic engineering and this expectation would reduce the perceived need to save for retirement.

Since understanding the consequences of a smarter workforce will increase the desire to borrow but reduce the wish to save, real interest rates will have to go up. These higher rates will reduce incentives to borrow while increasing the willingness to save and so will restore equilibrium to money markets. Expect to see higher interest rates as soon as markets price in embryo selection and genetic engineering.

Continue reading “Genetically enhancing our children could raise interest rates” | >

List of the who’s who are leading some of key bio programs around nextgen bio/ living cell technologies.

According to GEN’s experts, synthetic biology isn’t yet plug-and-play, but cellular processes are being engineered into biosensing systems as well as biologics production. Soon, for tasks from theranostics to regenerative medicine, “there will be a synbio app for that.”

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Using the CRISPR gene-editing tool, scientists from Harvard University have developed a technique that permanently records data into living cells. Incredibly, the information imprinted onto these microorganisms can be passed down to the next generation.

CRISPR/Cas9 is turning into an incredibly versatile tool. The cheap and easy-to-use molecular editing system that burst onto the biotech scene only a few years ago is being used for a host of applications, including genetic engineering, RNA editing, disease modeling, and fighting retroviruses like HIV. And now, as described in a new Science paper, it can also be used to turn lowly microorganisms into veritable hard drives.

http://io9.gizmodo.com/5935415/why-dna-is-the-future-of-data-storage

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Very cool.

Pinpointing the type of bacteria that are at the root of an infection in clinical samples removed from living tissues, such as blood, urine or joint fluids, to quickly identify the best anti-microbial therapy still poses a formidable challenge. The standard method of culturing can take days to reveal pathogens, and they often fail to bring them to light altogether.

A team lead by Donald Ingber, M.D., Ph.D., at the Wyss Institute for Biologically Inspired Engineering at Harvard University now reports a method in PLoS, which enables the rapid isolation and concentration of infectious bacteria from complex clinical samples to help speed up bacterial identification, and it should be able to accelerate the determination of antibiotic susceptibilities as well.

“We leveraged FcMBL? the genetically engineered pathogen-binding protein we developed for our sepsis therapeutic device program? to develop a fast and simple technology to help overcome this diagnostic roadblock,” said Ingber, who is the Wyss Institute’s Founding Director, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. “Using clinical samples of joint fluids, we were able to show that this method can be used to quickly and efficiently isolate bacterial pathogens for various kinds of subsequent analysis, including PCR, which is commonly used for molecular diagnostics in clinical laboratories.”

Continue reading “Engineered pathogen-binding protein enables rapid isolation of infectious bacteria from joint fluids” | >

How do organisms without brains make decisions? Most of life is brainless and the vast majority of organisms on Earth lack neurons altogether. Plants, fungi and bacteria must all cope with the same problem as humans — to make the best choices in a complex and ever-changing world or risk dying — without the help of a simple nervous system in many cases.

A team of researchers from New Jersey Institute of Technology (NJIT), the University of Sydney, the University of Sheffield and the University of Leeds recently studied this problem in the unicellular slime mold, Physarum polycephalum, a single-cell organism that can grow to several square meters in size. This giant cell, which typically lives in shady, cool and moist areas of temperate forests, spreads out to search its environment like an amoeba, extending oozy tendrils along the forest floor in search of its prey of fungi, bacteria and decaying vegetable matter.

Neither plant, animal nor fungus, P. polycephalum has become an unlikely candidate for studies of cognition, due to its spectacular problem-solving abilities. In recent studies, Physarum has been shown to solve labyrinth mazes, make complicated trade-offs, anticipate periodic events, remember where it has been, construct transport networks that have similar efficiency to those designed by human engineers and even make irrational decisions — a capability that has long been viewed as a by-product of brain circuitry.

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There are various animals that can live for centuries or millenia.

Genetic engineering technology is rapidly improving and genome wide genetic engineering could become a reality within 10–20 years. It could be possible to replicate in humans the longevity genes and cancer immunity in certain animals.

The longest lived mammal is the bowhead whales. Some confirmed sources estimate bowhead whales to have lived at least to 211 years of age.

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You’ve probably heard of CRISPR — the gene editing tool that essentially lets scientists cut and paste DNA, removing things like HIV and muscular dystrophy from our cells — and now scientists have discovered a way to edit RNA with just as much precision.

RNA is DNA’s close biological cousin, responsible for translating messages from the nucleus to the rest of the cell, and being able to change it could open up all-new disease-fighting possibilities.

Just like CRISPR/Cas9 editing, the new procedure selectively cuts up RNA, which gives us microscopic control over genetic information, and the researchers behind it say it could open up the method could be used to block viruses and halt disease in its tracks.

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