Lifeboat Foundation

Is Director of the Division of Research, Innovation and Ventures (DRIVe — https://drive.hhs.gov/) at the Biomedical Advanced Research and Development Authority (https://aspr.hhs.gov/AboutASPR/ProgramOffices/BARDA/Pages/default.aspx), a U.S. Department of Health and Human Services (HHS) office responsible for the procurement and development of medical countermeasures, principally against bioterrorism, including chemical, biological, radiological and nuclear (CBRN) threats, as well as pandemic influenza and emerging diseases.

Dr. Patel is committed to advancing high-impact science, building new products, and launching collaborative programs and initiatives with public and private organizations to advance human health and wellness. As the DRIVe Director, Dr. Patel leads a dynamic team built to tackle complex national health security threats by rapidly developing and deploying innovative technologies and approaches that draw from a broad range of disciplines.

Continue reading “Dr. Sandeep Patel, Ph.D. — BARDA — Developing Effective Life-Saving Medical Countermeasures For All” »

Dr. Renee Wegrzyn, Ph.D. is the inaugural director of the Advanced Research Projects Agency for Health (ARPA-H — https://arpa-h.gov/), an agency that supports the development of high-impact research to drive biomedical and health breakthroughs to deliver transformative, sustainable, and equitable health solutions for everyone. ARPA-H’s mission focuses on leveraging research advances for real world impact.

Previously, Dr. Wegrzyn served as a vice president of business development at Ginkgo Bioworks and head of Innovation at Concentric by Ginkgo, where she focused on applying synthetic biology to outpace infectious diseases—including Covid-19—through biomanufacturing, vaccine innovation and biosurveillance of pathogens at scale.

Continue reading “Dr. Renee Wegrzyn, Ph.D. — ARPA-H — Transformative, Sustainable, Equitable Health Solutions For All” »

Seminar summary: https://foresight.org/summary/bioelectric-networks-taming-th…-medicine/
Program & apply to join: https://foresight.org/biotech-health-extension-program/

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.

Continue reading “Bioelectric Networks: Taming the Collective Intelligence of Cells for Regenerative Medicine” »

Just when we are getting accustomed to artificial intelligence in our daily lives, get ready for a new disruptor: synthetic biology, or syn-bio, the design and engineering of biological systems to create and improve processes and products. It promises to become a manufacturing paradigm of the future.

Recent advances in molecular, cell, and systems biology have enabled scientists to shift their focus from research of syn-bio to design and engineering, creating some truly mind blowing applications. By using microorganisms, for example, companies can now manufacture an infinite number of things, cell by cell, from scratch. This offers new ways of producing almost everything that humans consume, from flavors and fabrics to foods and fuels.

By the end of the decade, syn-bio may be used extensively in manufacturing industries that account for more than a third of global output, according to BCG Henderson Institute, Boston Consulting Group’s strategy think tank. Various sources estimate that the syn-bio market today is about $10 billion and is expected to reach $30 billion in the next five years.

Arizona State University has officially begun a new chapter in X-ray science with a newly commissioned, first-of-its-kind instrument that will help scientists see deeper into matter and living things. The device, called the compact X-ray light source (CXLS), marked a major milestone in its operations as ASU scientists generated its first X-rays on the night of Feb. 2.

“This marks the beginning of a new era of science with compact accelerator-based X‑ray sources,” said Robert Kaindl, who directs ASU’s Compact X-ray Free Electron Laser (CXFEL) Labs at the Biodesign Institute and is a professor in the Department of Physics. “The CXLS provides hard X-ray pulses with high flux, stability and ultrashort durations, in a very compact footprint. This way, matter can be resolved at its fundamental scales in space and time, enabling new discoveries across many fields — from next-generation materials for computing and information science, to renewable energy, biomolecular dynamics, drug discovery and human health.”

Building the compact X-ray light source is the first phase of a larger CXFEL project, which aims to build two instruments including a coherent X-ray laser. As the first-stage instrument, the ASU CXLS generates a high-flux beam of hard X‑rays, with wavelengths short enough to resolve the atomic structure of complex molecules. Moreover, its output is pulsed at extremely short durations of a few hundred femtoseconds — well below a millionth of one millionth of a second — and thus short enough to directly track the motions of atoms.

Synthetic biology has made major strides towards the holy grail of fully programmable bio-micromachines capable of sensing and responding to defined stimuli regardless of their environmental context. A common type of bio-micromachines is created by genetically modifying living cells.^{[ 1 ]} Living cells possess the unique advantage of being highly adaptable and versatile.^{[ 2 ]} To date, living cells have been successfully repurposed for a wide variety of applications, including living therapeutics,^{[ 3 ]} bioremediation,^{[ 4 ]} and drug and gene delivery.^{[ 5, 6 ]} However, the resulting synthetic living cells are challenging to control due to their continuous adaption and evolving cellular context. Application of these autonomously replicating organisms often requires tailored biocontainment strategies,^{[ 7-9 ]} which can raise logistical hurdles and safety concerns.

In contrast, nonliving synthetic cells, notably artificial cells,^{[ 10, 11 ]} can be created using synthetic materials, such as polymers or phospholipids. Meticulous engineering of materials enables defined partitioning of bioactive agents, and the resulting biomimetic systems possess advantages including predictable functions, tolerance to certain environmental stressors, and ease of engineering.^{[ 12, 13 ]} Nonliving cell-mimetic systems have been employed to deliver anticancer drugs,^{[ 14 ]} promote antitumor immune responses,^{[ 15 ]} communicate with other cells,^{[ 16, 17 ]} mimic immune cells,^{[ 18, 19 ]} and perform photosynthesis.

Colossal Biosciences, a genetic engineering company focused on de-extincting past species, has announced $150 million in Series B funding, which it plans to use for bringing back the iconic dodo.

The resurrection of several extinct species is predicted to occur within the next five years. One company aiming to make that a reality is Texas-based startup Colossal Biosciences, founded in 2021 by some of the world’s leading experts in genomics. In May 2022, it appeared in the World Economic Forum’s list of Technology Pioneers and it won Genomics Innovation of the Year at the BioTech Breakthrough Awards.

Year 2020 This type of parasite that feeds on salmon actually doesn’t need oxygen to live. Which means eventually there could be even gene editing that could essentially allow humans to not need as much air or could be independent of oxygen but only need anaerobic metabolisms perhaps. Really this can only expand our understanding of new ways to evolve humans to the next level.

Although aerobic respiration is a hallmark of eukaryotes, a few unicellular lineages, growing in hypoxic environments, have secondarily lost this ability. In the absence of oxygen, the mitochondria of these organisms have lost all or parts of their genomes and evolved into mitochondria-related organelles (MROs). There has been debate regarding the presence of MROs in animals. Using deep sequencing approaches, we discovered that a member of the Cnidaria, the myxozoan Henneguya salminicola, has no mitochondrial genome, and thus has lost the ability to perform aerobic cellular respiration. This indicates that these core eukaryotic features are not ubiquitous among animals. Our analyses suggest that H. salminicola lost not only its mitochondrial genome but also nearly all nuclear genes involved in transcription and replication of the mitochondrial genome. In contrast, we identified many genes that encode proteins involved in other mitochondrial pathways and determined that genes involved in aerobic respiration or mitochondrial DNA replication were either absent or present only as pseudogenes. As a control, we used the same sequencing and annotation methods to show that a closely related myxozoan, Myxobolus squamalis, has a mitochondrial genome. The molecular results are supported by fluorescence micrographs, which show the presence of mitochondrial DNA in M. squamalis, but not in H. salminicola. Our discovery confirms that adaptation to an anaerobic environment is not unique to single-celled eukaryotes, but has also evolved in a multicellular, parasitic animal. Hence, H. salminicola provides an opportunity for understanding the evolutionary transition from an aerobic to an exclusive anaerobic metabolism.

Cyanobacteria are single-celled organisms that derive energy from light, using photosynthesis to convert atmospheric carbon dioxide (CO₂) and liquid water (H₂O) into breathable oxygen and the carbon-based molecules like proteins that make up their cells. Cyanobacteria were the first organisms to perform photosynthesis in the history of Earth, and were responsible for flooding the early Earth with oxygen, thus significantly influencing how life evolved.

Geological measurements suggest that the atmosphere of the early Earth—over three billion years ago—was likely rich in CO₂, far higher than current levels caused by anthropogenic climate change, meaning that ancient cyanobacteria had plenty to “eat.”

But over Earth’s multi-billion-year history, atmospheric CO₂ concentrations have decreased, and so to survive, these bacteria needed to evolve new strategies to extract CO₂. Modern cyanobacteria thus look quite different from their ancient ancestors, and possess a complex, fragile set of structures called a CO₂-concentrating mechanism (CCM) to compensate for lower concentrations of CO₂.