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Category: bioengineering – Page 35

Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones

HighlyCitedPapers.

📝 — Schulze, et al.

The present work reviews the strategies and technical approaches used to overcome the multilayered problems associated with large bone defect healing in long bones, with emphasis on research rooted in scaffold-guided tissue regeneration.

Full text is available 👇

Bone generally displays a high intrinsic capacity to regenerate. Nonetheless, large osseous defects sometimes fail to heal. The treatment of such large segmental defects still represents a considerable clinical challenge. The regeneration of large bone defects often proves difficult, since it relies on the formation of large amounts of bone within an environment impedimental to osteogenesis, characterized by soft tissue damage and hampered vascularization. Consequently, research efforts have concentrated on tissue engineering and regenerative medical strategies to resolve this multifaceted challenge. In this review, we summarize, critically evaluate, and discuss present approaches in light of their clinical relevance; we also present future advanced techniques for bone tissue engineering, outlining the steps to realize for their translation from bench to bedside.

This Simple Trait Is the Key to Longevity

To predict your #longevity, you have two main options. You can rely on the routine tests and measurements your doctor likes to order for you, such as blood pressure, cholesterol levels, weight, and so on. Or you can go down a biohacking rabbit hole the way tech millionaire turned longevity guru Bryan Johnson did to live longer. Johnson’s obsessive self-measurement protocol involves tracking more than a hundred biomarkers, ranging from the telomere length in blood cells to the speed of his urine stream (which, at 25 milliliters per second, he reports, is in the 90th percentile of 40-year-olds).

Scientists crunched the numbers to come up with the single best predictor of how long you’ll live—and arrived at a surprisingly low-tech answer.

Cas9-PE system achieves precise editing and site-specific random mutation in rice

Achieving the aggregation of different mutation types at multiple genomic loci and generating transgene-free plants in the T0 generation is an important goal in crop breeding. Although prime editing (PE), as the latest precise gene editing technology, can achieve any type of base substitution and small insertions or deletions, there are significant differences in efficiency between different editing sites, making it a major challenge to aggregate multiple mutation types within the same plant.

Recently, a collaborative research team led by Li Jiayang from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Science, developed a multiplex gene editing tool named the Cas9-PE system, capable of simultaneously achieving precise editing and site-specific random mutagenesis in rice.

By co-editing the ALSS627I gene to confer resistance to the herbicide bispyribac-sodium (BS) as a selection marker, and using Agrobacterium-mediated transient transformation, the researchers also achieved transgene-free gene editing in the T0 generation.

Serious side effect of using CRISPR-Cas gene scissors uncovered: AZD7648 molecule can destroy parts of genome

Its a problem, but im sure ASI by 2035 will solve for a way to use a Crispr type tool with zero unintended alterations. Look for a way to use w/ out alterations in meantime, but worst case ASI will solve it.

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years. Hundreds of labs around the world are now working to put these tools to clinical use and are continuously advancing them.

CRISPR-Cas tools allow researchers to modify individual building blocks of genetic material in a precise and targeted manner. Gene therapies based on such gene editing are already being used to treat inherited diseases, fight cancer and create drought-and heat-tolerant crops.

The CRISPR-Cas9 molecular complex, also known as genetic scissors, is the most widely used tool by scientists around the world. It cuts the double-stranded DNA at the exact site where the genetic material needs to be modified. This contrasts with newer gene-editing methods, which do not cut the double strand.

Protein engineering research reveals the mysteries of life, enabling advances in pharmaceuticals

Proteins are so much more than nutrients in food. Virtually every reaction in the body that makes life possible involves this large group of molecules. And when things go wrong in our health, proteins are usually part of the problem.

In certain types of heart disease, for instance, the proteins in cardiac tissue, seen with , are visibly disordered. Alex Dunn, professor of chemical engineering, describes proteins like the beams of a house: “We can see that in unhealthy heart muscle cells, all of those beams are out of place.”

Proteins are the workhorses of the cell, making the biochemical processes of life possible. These workhorses include enzymes, which bind to other molecules to speed up reactions, and antibodies that attach to viruses and prevent them from infecting cells.

Prof. Carlos Duarte, Ph.D. — Executive Director, Coral Research & Development Accelerator Platform

Professor Carlos Duarte, Ph.D. is Distinguished Professor, Marine Science, and Executive Director, Coral Research \& Development Accelerator Platform (CORDAP — https://cordap.org/), Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST — https://www.kaust.edu.sa/en/study/fac
), in Saudi Arabia, as well as Chief Scientist of Oceans2050, OceanUS, and E1Series.

Prior to these roles Professor Duarte was Research Professor with the Spanish National Research Council (CSIC) and Director of the Oceans Institute at The University of Western Australia. He also holds honorary positions at the Arctic Research Center in Aarhus University, Denmark and the Oceans Institute at The University of Western Australia.

Professor Duarte’s research focuses on understanding the effects of global change in marine ecosystems and developing nature-based solutions to global challenges, including climate change, and developing evidence-based strategies to rebuild the abundance of marine life by 2050.

Building on his research showing mangroves, seagrasses and salt-marshes to be globally-relevant carbon sinks, Professor Duarte developed, working with different UN agencies, the concept of Blue Carbon, as a nature-based solution to climate change, which has catalyzed their global conservation and restoration.

For the past years, Professor Duarte has also lead efforts to quantify the global role and importance of algal forests. He has conducted research across all continents and oceans, spanning most of the marine ecosystem types, from inland to near-shore and the deep sea and from microbes to whales, and has a particular focus on the role of seaweed aquaculture as a sustainable solution for multiple challenges.

Professor Duarte led the Malaspina 2010 Expedition, including over 700 scientists from 38 institutions from across 18 nations, that sailed the world’s oceans to examine the impacts of global change on ocean ecosystems and explore deep-sea biodiversity.

Continue reading “Prof. Carlos Duarte, Ph.D. — Executive Director, Coral Research & Development Accelerator Platform” | >

Engineering a Faster, More Efficient Soft Robot with Manta Ray-Inspired Fins

“This is a highly engineered design, but the fundamental concepts are fairly simple,” said Dr. Jie Yin. “And with only a single actuation input, our robot can navigate a complex vertical environment.”

What influence can marine life have on robotics? This is what a recent study published in Science Advances hopes to address as a team of researchers from the University of Virginia and North Carolina State University have developed the fastest swimming soft robot by taking cues from manta ray fins. This study holds the potential to help researchers, engineers, and scientists develop faster and more efficient swimming soft robots that can be used for a variety of purposes worldwide.

This study builds on a 2022 study conducted by this same team of researchers that explored swimming soft robots that exhibited butterfly strokes, achieving a then-record of 3.74 body lengths per second, along with demonstrating high power efficiency, low energy use, and high maneuverability. For this new study, the researchers developed fins used by manta rays with the goal of achieving greater results than before. The fins are flexible when not in use but become rigid when the researchers pumped air into the silicone body that encompasses the soft robot.

In the end, the researchers not only achieved low energy use and maneuverability, but also broke their own record of body lengths per second at 6.8. Additionally, the manta ray-inspired swimming soft robot was able to avoid obstacles, which was an improvement from their 2022 study.

Tiny dancers: Scientists synchronize bacterial motion

Researchers at TU Delft have discovered that E. coli bacteria can synchronize their movements, creating order in seemingly random biological systems. By trapping individual bacteria in micro-engineered circular cavities and coupling these cavities through narrow channels, the team observed coordinated bacterial motion. Their findings, which have potential applications in engineering controllable biological oscillator networks, were recently published in Small.

An audience clapping in rhythm, fireflies flashing in unison, or flocks of starlings moving as one—synchronization is a natural phenomenon observed across diverse systems and scales. First described by Christiaan Huygens in the 17th century, synchronization was famously illustrated by the aligned swinging of his pendulum clocks. Now, TU Delft researchers have shown that even E. coli bacteria—single-celled organisms only a few micrometers long—can display this same phenomenon.

“This was a remarkable moment for our team,” said Farbod Alijani, associate professor at the Faculty of Mechanical Engineering. “Seeing bacteria ‘dance in sync’ not only showcases the beauty of nature but also deepens our understanding of the microscopic origins of self-organization among the smallest living organisms.”

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