Lifeboat Foundation

Hey folks, I’m excited to share a new essay with y’all on my proposed route towards nanoscale human brain connectomics. I suggest that synchrotron ‘expansion x-ray microscopy’ has the potential to enable anatomical imaging of the entire human brain with sub-100 nm voxel size and high contrast in around 1 year for a price of roughly $10M. I plan to continue improving this essay over time as I acquire more detailed information and perform more calculations.

For a brief history of this concept: I started exploring this idea during undergrad (working with a laboratory-scale x-ray microscope), but was cut short by the pandemic. Now, I’m working on a PhD in biomedical engineering centered on gene therapy and synthetic biology, but I have retained a strong interest in connectomics. I recently began communication with some excellent collaborators who might be able to help move this technology forward. Hoping for some exciting progress!

By Logan Thrasher Collins.

Continue reading “Feasibility of mapping the human brain with expansion x-ray microscopy” »

Gustavo Raskosky/Rice University.

Thus, engineered wood has emerged as a sustainable and environmentally friendly alternative to traditional building materials. However, this wood is prone to warping and deterioration of structural integrity, diminishing its life span.

Watch this next video about the Future of Artificial Intelligence (2030 — 10,000 A.D.+): https://youtu.be/cwXnX49Bofk.
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SOURCES:
• Life 3.0: Being Human in the Age of Artificial Intelligence (Max Tegmark): https://amzn.to/3xrU351
• The Future of Humanity (Michio Kaku): https://amzn.to/3Gz8ffA
• The Singularity Is Near: When Humans Transcend Biology (Ray Kurzweil): https://amzn.to/3ftOhXI

Official Discord Server: https://discord.gg/R8cYEWpCzK
Patreon Page: https://www.patreon.com/futurebusinesstech.

💡 Future Business Tech explores the future of technology and the world.

Continue reading “This video explores Artificial Super Intelligence and how it will change the world” »

A persistent technological challenge has been the difficulty in scaling down the electrochemical performance of large-format batteries to smaller, microscale power sources, hindering their ability to power microdevices, microrobots, and implantable medical devices. However, researchers at the University of Illinois Urbana-Champaign have overcome this challenge by developing a high-voltage microbattery (9 V) with exceptional energy and power density, unparalleled by any existing battery design.

Material Science and Engineering Professor Paul Braun (Grainger Distinguished Chair in Engineering, Materials Research Laboratory Director), Dr. Sungbong Kim (Postdoc, MatSE, current assistant professor at Korea Military Academy, co-first author), and Arghya Patra (Graduate Student, MatSE, MRL, co-first author) recently published a paper detailing their findings in Cell Reports.

<em>Cell Reports</em> is a peer-reviewed scientific journal that published research papers that report new biological insight across a broad range of disciplines within the life sciences. Established in 2012, it is the first open access journal published by Cell Press, an imprint of Elsevier.

Year 2020 face_with_colon_three

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two fatal and incurable neurodegenerative diseases linked by a shared genetic cause – a heterozygous hexanucleotide (GGGGCC) repeat expansion in a single allele of the C9orf72 gene. The goal of this work is to develop novel CRISPR based therapeutic gene editing technologies and test whether gene editing can reverse the cellular pathology caused by this repeat expansion in patient derived cells. The results of these studies will advance our use of CRISPR technologies for therapeutic editing in FTD/ALS, inform our understanding of the regulation of C9orf72 gene, and will be applicable to many other repeat expansion and single gene disorders.

https://www.youtube.com/watch?v=caT3j…

The math behind Evo-devo~

Continue reading “The math behind engineering living things (TMEB #3)” »

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have removed a major roadblock to better understanding of mpox (formerly, monkeypox). They developed a mouse model of the disease and used it to demonstrate clear differences in virulence among the major genetic groups (clades) of mpox virus (MPXV).

The research, appearing in Proceedings of the National Academy of Science, was led by Bernard Moss, M.D., Ph.D., chief of the Genetic Engineering Section of NIAID’s Laboratory of Viral Diseases.

Historically, mpox, a disease resembling smallpox, was only occasionally transmitted from rodents to non-human primates or people, and was observed primarily in several African countries. Mpox rarely spread from person to person. That pattern changed in 2022 with an outbreak in which person-to-person mpox transmission occurred in more than 100 locations worldwide.

An artificial intelligence program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

The researchers at NYU Grossman School of Medicine and the University of Toronto who designed the tool say it promises to accelerate the development of gene therapies on a large scale.

Illnesses including cystic fibrosis, Tay-Sachs disease, and sickle cell anemia are caused by errors in the order of DNA letters that encode the operating instructions for every human cell. Scientists can in some cases correct these mistakes with gene editing methods that rearrange these letters.

Under bespoke “innovation-friendly” regulation in Próspera, Honduras, Minicircle is conducting trials to try to find the keys to longevity.