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Category: bioengineering – Page 79

Anti-aging Supplements: Science, Snake Oil, and How Do We Know?

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In this Ask Me Anything interview, Prof. Matt Kaeberlein discusses the evidence (and lack thereof) behind popular anti-aging supplements and interventions. Starting from his current research on rapamycin for healthy longevity in dogs (The Dog Aging Project), he describes the promises and perils of anti-aging medicine and shares with us some tips on how to become better critical thinkers and protect us from hype and snake oil.

This interview is a must watch for everyone who wants to develop a critical stance toward the field of longevity research and balance enthusiasm with evidence.

I hope you enjoy this interview!

TIMESTAMPS
00:00 Introduction.
04:33 Definitions: Aging, lifespan, healthspan.
09:08 What is biohacking.
14:56 The Dog Aging project.
19:39 Rapamycin: Longevity effects in mice.
22:28 Can rapamycin impair muscle growth? Is it in contraindicated for people who want to build muscle mass?
27:09 Exercise, inhibition of mTor, and rationale for cycling rapamycin and exercise.
29:46 Getting around the growth vs. resilience tradeoff in longevity.
32:00 Epigenetic clocks: Hope vs. hype.
32:43 Best functional markers of longevity.
36:30 Sterile inflammation, auto-immunity, and immune senescence.
40:24 The best and worst longevity supplements for Matt Kaeberlein.
45:50 What longevity hacks Matt implements in his own life.
48:00 Lucia’s and Matt’s thoughts on calorie restriction for longevity.
50:30 How can people discriminate between science and sneak oil?

đŸ¶ The Dog Aging project: https://dogagingproject.org/

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Singularity Timeline | Is Super Artificial Intelligence The END of Humanity?

Artificial Intelligence AI

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Did you think that technology getting too advanced and wiping away humanity was something that happened only in movies? You might be shocked by what you find today.

Robots ‘will reach human intelligence by 2029 and life as we know it will end in 2045’.

This isn’t the prediction of a conspiracy theorist, a blind dead woman or an octopus but of Google’s chief of engineering, Ray Kurzweil.

Kurzweil has said that the work happening now ‘will change the nature of humanity itself’.

Continue reading “Singularity Timeline | Is Super Artificial Intelligence The END of Humanity?” | >

DNA repair discovery could improve biotechnology

A team of researchers from Michigan State University’s College of Veterinary Medicine has made a discovery that may have implications for therapeutic gene editing strategies, cancer diagnostics and therapies and other advancements in biotechnology.

Kathy Meek, a professor in the College of Veterinary Medicine, and collaborators at Cambridge University and the National Institutes of Health have uncovered a previously unknown aspect of how DNA double-stranded breaks are repaired.

A large protein kinase called DNA-PK starts the DNA repair process; in their new report, two distinct DNA-PK protein complexes are characterized, each of which has a specific role in DNA repair that cannot be assumed by the other.

Groundbreaking Biomaterial Heals Tissues From the Inside Out

The substance can be administered via intravenous injection and holds the possibility of being used in the treatment of conditions such as heart attacks and traumatic brain injury, among others.

An innovative biomaterial has been developed that, when injected intravenously, reduces inflammation and stimulates cell and tissue repair. The efficacy of this biomaterial in treating heart attack-induced tissue damage was demonstrated through successful testing on both rodent and large animal models. The researchers also provided proof of concept, based on a rodent study, suggesting that the biomaterial may prove beneficial in the treatment of traumatic brain injury and pulmonary arterial hypertension.

“This biomaterial allows for treating damaged tissue from the inside out,” said Karen Christman, a professor of bioengineering at the University of California San Diego, and the lead researcher on the team that developed the material. “It’s a new approach to regenerative engineering.”

3D bioprinting inside the human body could be possible thanks to new soft robot

Engineers from UNSW Sydney have developed a miniature and flexible soft robotic arm which could be used to 3D print biomaterial directly onto organs inside a person’s body.

3D bioprinting is a process whereby biomedical parts are fabricated from so-called bioink to construct natural tissue-like structures.

Bioprinting is predominantly used for research purposes such as tissue engineering and in the development of new drugs — and normally requires the use of large 3D printing machines to produce cellular structures outside the living body.

Paper Advanced Sciences:

Advanced soft robotic system for in situ 3D bioprinting and endoscopic surgery.

https://onlinelibrary.wiley.com/doi/10.1002/advs.

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Feasibility of mapping the human brain with expansion x-ray microscopy

Hey folks, I’m excited to share a new essay with y’all on my proposed route towards nanoscale human brain connectomics. I suggest that synchrotron ‘expansion x-ray microscopy’ has the potential to enable anatomical imaging of the entire human brain with sub-100 nm voxel size and high contrast in around 1 year for a price of roughly $10M. I plan to continue improving this essay over time as I acquire more detailed information and perform more calculations.

For a brief history of this concept: I started exploring this idea during undergrad (working with a laboratory-scale x-ray microscope), but was cut short by the pandemic. Now, I’m working on a PhD in biomedical engineering centered on gene therapy and synthetic biology, but I have retained a strong interest in connectomics. I recently began communication with some excellent collaborators who might be able to help move this technology forward. Hoping for some exciting progress!

By Logan Thrasher Collins.

PDF version

This video explores Artificial Super Intelligence and how it will change the world

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SOURCES:
‱ Life 3.0: Being Human in the Age of Artificial Intelligence (Max Tegmark): https://amzn.to/3xrU351
‱ The Future of Humanity (Michio Kaku): https://amzn.to/3Gz8ffA
‱ The Singularity Is Near: When Humans Transcend Biology (Ray Kurzweil): https://amzn.to/3ftOhXI

Official Discord Server: https://discord.gg/R8cYEWpCzK
Patreon Page: https://www.patreon.com/futurebusinesstech.

💡 Future Business Tech explores the future of technology and the world.

https://youtu.be/cwXnX49Bofk.

Examples of topics I cover include:
‱ Artificial Intelligence & Robotics.
‱ Virtual and Augmented Reality.
‱ Brain-Computer Interfaces.
‱ Transhumanism.
‱ Genetic Engineering.

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Surpassing All Existing Designs — Researchers Develop High-Voltage Microbattery With Exceptional Energy and Power Density

A persistent technological challenge has been the difficulty in scaling down the electrochemical performance of large-format batteries to smaller, microscale power sources, hindering their ability to power microdevices, microrobots, and implantable medical devices. However, researchers at the University of Illinois Urbana-Champaign have overcome this challenge by developing a high-voltage microbattery (9 V) with exceptional energy and power density, unparalleled by any existing battery design.

Material Science and Engineering Professor Paul Braun (Grainger Distinguished Chair in Engineering, Materials Research Laboratory Director), Dr. Sungbong Kim (Postdoc, MatSE, current assistant professor at Korea Military Academy, co-first author), and Arghya Patra (Graduate Student, MatSE, MRL, co-first author) recently published a paper detailing their findings in Cell Reports.

<em>Cell Reports</em> is a peer-reviewed scientific journal that published research papers that report new biological insight across a broad range of disciplines within the life sciences. Established in 2012, it is the first open access journal published by Cell Press, an imprint of Elsevier.

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