Let’s be clear.
What can we trust? Why is the ‘information ecology’ so damaged, and what would it take to make it healthy?
Continue reading “The War on Sensemaking, Daniel Schmachtenberger” »
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The discovery of an exceptionally strong “forbidden” beta-decay involving fluorine and neon could change our understanding of the fate of intermediate-mass stars.
Every year roughly 100 billion stars are born and just as many die. To understand the life cycle of a star, nuclear physicists and astrophysicists collaborate to unravel the physical processes that take place in the star’s interior. Their aim is to determine how the star responds to these processes and from that response predict the star’s final fate. Intermediate-mass stars, whose masses lie somewhere between 7 and 11 times that of our Sun, are thought to die via one of two very different routes: thermonuclear explosion or gravitational collapse. Which one happens depends on the conditions within the star when oxygen nuclei begin to fuse, triggering the star’s demise. Researchers have now, for the first time, measured a rare nuclear decay of fluorine to neon that is key to understanding the fate of these “in between” stars [1, 2]. Their calculations indicate that thermonuclear explosion and not gravitational collapse is the more likely expiration route.
The evolution and fate of a star strongly depend on its mass at birth. Low-mass stars—such as the Sun—transition first into red giants and then into white dwarfs made of carbon and oxygen as they shed their outer layers. Massive stars—those whose mass is at least 11 times greater than the Sun’s—also transition to red giants, but in the cores of these giants, nuclear fusion continues until the core has turned completely to iron. Once that happens, the star stops generating energy and starts collapsing under the force of gravity. The star’s core then compresses into a neutron star, while its outer layers are ejected in a supernova explosion. The evolution of intermediate-mass stars is less clear. Predictions indicate that they can explode both via the gravitational collapse mechanism of massive stars and by a thermonuclear process [3– 6]. The key to finding out which happens lies in the properties of an isotope of neon and its ability to capture electrons.
Neurochemicals such as serotonin and dopamine play crucial roles in cognitive and emotional functions of our brain. Vesicular monoamine transporter 1 (VMAT1) is one of the genes responsible for transporting neurotransmitters and regulating neuronal signaling. A research team led by Tohoku University has reconstructed ancestral VMAT1 proteins, revealing the functional changes in neurotransmitter uptake of VMAT1 throughout the course of human evolution.
Human bodies are made up of millions of cells. Each individual contains a specific set of instruction of codes that make up all of a living thing’s genetic material. These instructions are known as genomes. PhD candidate Daiki Sato and Professor Masakado Kawata of the Graduate School of Life Sciences at Tohoku University, and two of the authors involved in the current study, previously discovered VMAT1 to be one of the genes that had evolved throughout human lineage.
VMAT 1 contains two human-specific mutations, or where the genomes changed, with the change being represented as 130Glu to 130Gly and from 136Asn to 136Thr. Previous studies have shown that having the new 130Gly/136Thr variant decreases the uptake of neurotransmitters and is associated with higher depression and/or anxiety. In this study, Sato, Kawata and their colleagues revealed the evolutionary changes in neurotransmitter uptake of VMAT1 by reconstructing ancestral VMAT1 proteins. First they applied a fluorescent substrate to visualize and quantify the neurotransmitter uptake of each genotype. The ancestral (130Glu/136Asn) VMAT1 protein exhibited an increased uptake of neurotransmitters compared to a derived (130Gly/136Thr) genotype. Given that the derived (130Gly/136Thr) genotype is shown to be associated with depression and/or anxiety in modern human populations. “This results of our study reveal that our ancestors may have been able to withstand higher levels of anxiety or depression,” noted the authors.
Continue reading “Evolutionary Changes in Brain Potentially Make us More Prone to Anxiety” »
A physicist from RUDN University has proposed a new theoretical model for the interaction of spinor and gravitational fields. He considered the evolution of the universe within one of the variants of the widespread Bianchi cosmological model. In this case, a change in the calculated field parameters led to changes in the evolution of the universe under consideration. Upon reaching certain values, it began to shrink down to the Big Bang. The article was published in the journal The European Physical Journal Plus.
The spinor field is characterized by its behavior in interaction with gravitational fields. Dr. Bijan Saha of RUDN University focused on the study of a nonlinear spinor field. With its help, he explained the accelerated expansion of the universe. The study of a spinor field with a non-minimal coupling made it possible to describe not only the expansion of the universe, but also its subsequent contraction and the resulting Big Bang within the framework of the standard Bianchi cosmological model.
The basic calculations performed by Bijan Saha allow moving away from the isotropic model of the Friedman-Robertson-Walker universe (FRW) that is most often used. According to this traditional model, the properties of the universe are independent of the direction in which they are considered. The physicist has put forward an alternative: an anisotropic model in which such dependence exists. On the one hand, the “classical” isotropic model describes the evolution of the modern universe with great precision. On the other hand, there are theoretical arguments and observational data that lead to the conclusion that an anisotropic phase existed in the distant past.
Bacteria and the viruses that infect them are engaged in a molecular arms race as ancient as life itself. Evolution has equipped bacteria with an arsenal of immune enzymes, including CRISPR-Cas systems, that target and destroy viral DNA. But bacteria-killing viruses, also known as phages, have devised their own tools to help them outmaneuver even the most formidable of these bacterial defenses.
Now, scientists at UC San Francisco and UC San Diego have discovered a remarkable new strategy that some phages employ to avoid becoming the next casualty of these DNA-dicing enzymes: after they infect bacteria, these phages construct an impenetrable “safe room” inside of their host, which protects vulnerable phage DNA from antiviral enzymes. This compartment, which resembles a cell nucleus, is the most effective CRISPR shield ever discovered in viruses.
“In our experiments, these phages didn’t succumb to any of the DNA-targeting CRISPR systems they were challenged with. This is the first time that anyone has found phages that exhibit this level of pan-CRISPR resistance,” said Joseph Bondy-Denomy, Ph.D., assistant professor in the Department of Microbiology and Immunology at UCSF. Bondy-Denomy led the research team that made the discovery, which is detailed in a paper published Dec. 9, 2019 in the journal Nature.
Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Penelope “Penny” Boston, recent Director of NASA’s Astrobiology Institute.
Astrobiology is an interdisciplinary scientific field concerned with the origins, early evolution, distribution, and future of life in the universe, and considers the big question of whether extraterrestrial life exists, and if it does, how humans can detect it.
Continue reading “Astrobiology And The Search For Extraterrestrial Like Life” »
The current Lambda CDM model may explain a great deal about the evolution and the chronology of the events that occurred in our Universe but it doesn’t paint the complete picture.
We know of the cosmic inflation that happened followed by the Big Bang itself however how these two are coherently connected has so far defied all our attempts to explain.
During the inflationary period, within less than a trillionth of a second, our universe grew from an infinitesimal point to an octillion (that’s 1 followed by 27 zeroes) times in size, which was followed by a more conventional and gradual period of expansion, nevertheless violent by our standards, which we know as the Big Bang.
It’s easy to get excited about breast milk. Just the basic fact that a woman can eat food and turn it into a complete food instantly tailored to grow that particular newborn is quite outstanding. But there is more to breast milk than what meets the eye and understanding the perfection of it could mean a better life for premature babies.
For starters, when a baby suckles her mama’s breast, a vacuum is created. That’s right. Saliva in, milk out. The infant’s saliva is sucked back into the mother’s nipple, where receptors in her mammary gland read its signals. Katie Hinde, a biologist and associate professor at the Center for Evolution and Medicine at the School of Human Evolution & Social Change at Arizona State University, calls this “baby spit backwash,” and it contains information about the baby’s immune status. As far as scientists can tell, baby spit backwash is one of the ways that breast milk adjusts its immunological composition. When mammary gland receptors detect the presence of pathogens, the mother’s body produces antibodies to fight it, and those antibodies travel through breast milk back into the baby’s body, where they target the infection.
“[Breast] Milk is so incredibly dynamic,” says Hinde. “There are hormones in breast milk, and they reflect the hormones in the mother’s circulation. The ones that help facilitate sleep or waking up are present in your milk. And day milk is going to have a completely different hormonal milieu than night milk.” That broken-down means that breastmilk made at night contains hormones that help your baby sleep.
Continue reading “Studies Show that Breast Milk Grows Premature Infant Brains Faster than Formula” »
