Lifeboat Foundation

Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of species.

Aging and the nucleolus

There are two kinds of age: chronological age, which is strictly the number of years that something has lived, and biological age, which is influenced by diet, exercise, environment, and similar factors. Biological age is the superior measure of true age and is an accurate predictor of all-cause mortality.

Continue reading “New Aging Clock Accurately Predicts Biological Age” »

Circa 2008

“Truth uncompromisingly told will always have its ragged edges.” Herman Melville.

Call me Ishmael for making conjectures unflattering to humankind, but could Moby Dick have been smarter than captain Ahab? Melville certainly seemed to think so. Moby clipped off one of the captain’s legs and then, years later, in a brilliant move of cetacean jujitsu, drowned poor Ahab by towing him into the abyss by the harpoon rope tangled around Ahab’s remaining leg. “From Hell’s heart I stab at thee!” Gulp. We humans pride ourselves on our big brains. We never seem to tire of bragging about how our supreme intelligence empowers us to lord over all other animals on the planet. Yet the biological facts don’t quite square with Homo sapiens’ arrogance. The fact is, people do not have the largest brains on the planet, either in absolute size or in proportion to body size. Whales, not people, have the biggest brains of any animal on earth.

Continue reading “Are Whales Smarter Than We Are?” »

Lifetime adversity and increased neural processing during a traumatic event combine to increase the frequency of intrusive traumatic memories and the distress they cause, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. The increased neural processing was found in brain regions important for emotion and memory. The involuntary recollection of traumatic events is a core symptom of posttraumatic stress disorder (PTSD), and the findings could help explain why some people are susceptible to the effects of traumatic experiences and others are resilient.

“Understanding why some people develop intrusive thoughts of a stressful or traumatic event and others do not is an important step towards preventing and treating posttraumatic stress disorder,” said Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Due to the nature of real-life trauma, which happens randomly and encompasses many different kinds of adversity, it is impossible to examine how neural processing during natural events contributes to PTSD. Researchers at the University of Salzburg, Austria, have now completed the first study of two well-known risk factors of PTSD, using fMRI to measure brain function during experimental trauma. After watching disturbing films of severe interpersonal violence, the study participants reported how often they experienced intrusive memories of the films, and how distressing the memories were. “This allowed us to study how the brain deals with intensely emotional events,” said lead author Julina Rattel, MSc, a Ph.D. student in the laboratory of senior author Frank Wilhelm, Ph.D.

Psychiatry as a field, meanwhile, quivers with theoretical uncertainty. It has not become a sub-speciality of neurology, as one might have expected if mental illness mapped directly to neural behaviour. And common genetic variations with large effects on mental disorders are elusive. The various incarnations of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM) have enabled diagnostic consistency and the objectification of mental illnesses. But the DSM has resulted in overlapping diagnoses, and contrived symptom-cluster checklists. At times, it impinges on the territory of healthy mental function. Allen Frances, chair of the task force that wrote the manual’s fourth edition in 1994, revolted against out-of-control mental diagnosis in his 2013 book DSM: Saving Normal.

Adrian Woolfson weighs up a study on the role of evolution in conditions such as depression and anxiety.

Project fear? Should we pay attention to American Jesuits?

But the fundamental ambition of transhumanism is more problematic. Its architects champion a use of technology to accelerate the evolution of humanity so radically that at the end of the process humanity as such would disappear. A superior posthuman being would emerge. According to Wikipedia, “Transhumanism is the intellectual and cultural movement that affirms the possibility and desirability of fundamentally improving the human condition through applied reason, especially by developing and making widely available knowledge to eliminate aging and to greatly enhance human intellectual, physical, and psychological capacities.” From its inception, the abolition of human death and aging has been one of the goals of transhumanism as it engineers a new being freed from the biological constraints of the current human condition.

From its inception, the abolition of human death and aging has been one of the goals of transhumanism.

Continue reading “Who’s afraid of transhumanism? (We all should be)” »

Researchers develop an app that can estimate the biological age of a rodent from its mug shot, and could give a boost to the science of human aging in the process.

The 107-country Outer Space Treaty signed in 1967 prohibits nuclear, biological, or chemical weapons from being placed in or used from Earth’s orbit.

What they didn’t count on was the US Air Force’s most simple weapon ever: a tungsten rod that could hit a city with the explosive power of an intercontinental ballistic missile.

During the Vietnam War, the US used what it called “Lazy Dog” bombs. These were simply solid-steel pieces, less than 2 inches long, fitted with fins.

Continue reading “The Air Force’s ‘rods from god’ could hit with the force of a nuclear weapon — with no fallout” »

Human health depends on age and evolutionary history. Firstly, adaptation is age-specific, with Hamilton’s forces of natural selection leading to much greater adaptation at earlier ages than later ages. This of course is how evolutionary biologists explain the existence of aging in the first place. Secondly, when environmental conditions change, it takes surprisingly few generations for populations to adapt to such new conditions, at least at early ages when natural selection is intense. Thirdly, at later ages, when the forces of natural selection are weak, natural selection will often fail to produce adaptation to a selective environment that is not evolutionarily ancient. All three of these themes will be illustrated using both explicit mathematical theory and findings from experimental evolution. At the end of the presentation, we will apply these general scientific insights to the case of human evolutionary history, human aging, and optimal human diets.