БЛОГ

Archive for the ‘biological’ category: Page 197

Jul 6, 2009

Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease

Posted by in categories: biological, biotech/medical, neuroscience

Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease



Alzheimer’s disease afflicts some 20 million people world-wide, over 5 million people of whom reside in the United States. It is currently the seventh-leading cause of death in the US. The number of people with the disease is predicted to increase by over 50% by 2030. The economic as well as emotional costs are huge, the costs being estimated as more than $148 billion each year (direct and indirect, for of all types of dementia, to Medicare, Medicaid and businesses).

The causes of Alzheimer’s disease are unknown, apart from the very small proportion with familial disease. We are investigating the involvement of infectious agents in the disease, with particular emphasis on the virus that causes oral herpes/cold sores/fever blisters. We discovered that most elderly humans harbour this virus in their brains and that in those (and only those) who possess a certain genetic factor, the virus confers a strong risk of developing Alzheimer’s disease. Also, we found that the virus is directly involved with the characteristic abnormalities seen in the brains of Alzheimer’s disease patients.

There are several treatment possibilities available to combat this virus and all would be suitable candidates as therapies in Alzheimer’s disease. However, much more research is needed before trials of these agents for Alzheimer’s disease in humans can begin.

In these financially difficult times many funding bodies have to prioritise projects based around long established hypotheses. Projects involving new avenues of investigation can receive very positive comments by scientific reviewers, yet are rarely funded, as they almost always appear risky compared with projects largely confirming or expanding existing ideas. Such conservative projects are almost guaranteed to produce useful data, though with modest impact. This situation can mean that research proposals with the potential to transform our understanding of a disease and offer new approaches to its treatment never reach the threshold for funding and are not implemented, even though the potential and quality of the science is acknowledged by reviewers and funding panel.

It appears that our work examining a viral cause for Alzheimer’s disease is in this category. Despite our publishing a large number of potentially very exciting papers on this topic, and despite our research projects being reviewed favourably by scientific referees, few funding panels are prepared to commit resources to fund our work, as by doing so they deny funding to other more straightforward, very low risk projects.

We are therefore actively seeking sponsorship for several projects of varying costs to investigate the interaction of virus and specific genetic factor, the pathways of viral damage in the brain, and the effects of antiviral agents. All the projects would provide significant evidence strengthening the case for trialling antiviral agents in Alzheimer’s disease.

Antiviral agents would inhibit a likely major cause of the disease in contrast to current treatments, which merely inhibit the symptoms.

If any Lifeboat member knows of a company or individual that would be interested in sponsoring some of our research on Alzheimer’s disease then please contact me for further details.

Ruth Itzhaki

Continue reading “Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease” »

Jul 2, 2009

Alan Turing: Biology, Evolution and Artificial Intelligence

Posted by in categories: biological, robotics/AI

It will probably come as a surprise to those who are not well acquainted with the life and work of Alan Turing that in addition to his renowned pioneering work in computer science and mathematics, he also helped to lay the groundwork in the field of mathematical biology(1). Why would a renowned mathematician and computer scientist find himself drawn to the biosciences?

Interestingly, it appears that Turing’s fascination with this sub-discipline of biology most probably stemmed from the same source as the one that inspired his better known research: at that time all of these fields of knowledge were in a state of flux and development, and all posed challenging fundamental questions. Furthermore, in each of the three disciplines that engaged his interest, the matters to which he applied his uniquely creative vision were directly connected to central questions underlying these disciplines, and indeed to deeper and broader philosophical questions into the nature of humanity, intelligence and the role played by evolution in shaping who we are and how we shape our world.

Central to Turing’s biological work was his interest in mechanisms that shape the development of form and pattern in autonomous biological systems, and which underlie the patterns we see in nature (2), from animal coat markings to leaf arrangement patterns on plant stems (phyllotaxis). This topic of research, which he named “morphogenesis,” (3) had not been previously studied with modeling tools. This was a knowledge gap that beckoned Turing; particularly as such methods of research came naturally to him.

In addition to the diverse reasons that attracted him to the field of pattern formation, a major ulterior motive for his research had to do with a contentious subject which, astonishingly, is still highly controversial in some countries to this day. In studying pattern formation he was seeking to help invalidate the “argument from design(4) concept, which we know today as the hypothesis of “Intelligent Design.

Continue reading “Alan Turing: Biology, Evolution and Artificial Intelligence” »

Jun 18, 2009

Extra Germs and Toxins Found

Posted by in categories: biological, defense, military

Here’s a story that should concern anyone wanting to believe that the military has a complete and accurate inventory of chemical and biological warfare materials.

“An inventory of deadly germs and toxins at an Army biodefense lab in Frederick found more than 9,200 vials of material that was unaccounted for in laboratory records, Fort Detrick officials said Wednesday. The 13 percent overage mainly reflects stocks left behind in freezers by researchers who retired or left Fort Detrick since the biological warfare defense program was established there in 1943, said Col. Mark Kortepeter, deputy commander of the U.S. Army Medical Research Institute of Infectious Diseases.”

The rest of the story appears here:
http://abcnews.go.com/Health/wireStory?id=7863828

Given that “The material was in tiny, 1mm vials that could easily be overlooked,” and included serum from Korean hemorrhagic fever patients, the lack of adequate inventory controls to this point creates the impression that any number of these vials could be outside their lab. Of course, they assure us they have it all under control. Which will be cold comfort if we don’t have a lifeboat.

Jun 16, 2009

Microbe on Ice

Posted by in categories: biological, lifeboat

It sounds like cryonics is working, at least for microbes. But could any humans now alive have resistance to ancient organisms?

Rational Review carried a link to this story:

http://www.foxnews.com/story/0,2933,526460,00.html

“After more than 120,000 years trapped beneath a block of ice in Greenland, a tiny microbe has awoken. … The new bacteria species was found nearly 2 miles (3 km) beneath a Greenland glacier, where temperatures can dip well below freezing, pressure soars, and food and oxygen are scarce. ‘We don’t know what state they were in,’ said study team member Jean Brenchley of Pennsylvania State University. ‘They could’ve been dormant, or they could’ve been slowly metabolizing, but we don’t know for sure.’”

It is yet another interesting possibility against which humans should prepare to protect ourselves. Where is our Lifeboat?

May 17, 2009

Dr. Moreau outlawed in LA — Panel Votes to Outlaw Human-Animal Hybrids

Posted by in categories: biological, biotech/medical, human trajectories

U.S. News and World Report — May 12, 2009, by KEVIN McGILL

BATON ROUGE, La.—Combining human and animal cells to create what are sometimes called “human-animal hybrids” would be a crime in Louisiana, punishable by up to 10 years in prison, under legislation approved Tuesday by a state Senate panel.

Scientific researchers in some areas have tried to create human embryonic stem cells, which scientists say could be used to develop treatment for a variety of human ailments, by placing human DNA into animal cells. But such practices are controversial for a number of reasons.

Continue reading “Dr. Moreau outlawed in LA — Panel Votes to Outlaw Human-Animal Hybrids” »

May 4, 2009

Forever Young

Posted by in categories: biological, biotech/medical, futurism, human trajectories, media & arts, space

(Crossposted on the blog of Starship Reckless)

Eleven years ago, Random House published my book To Seek Out New Life: The Biology of Star Trek. With the occasion of the premiere of the Star Trek reboot film and with my mind still bruised from the turgid awfulness of Battlestar Galactica, I decided to post the epilogue of my book, very lightly updated — as an antidote to blasé pseudo-sophistication and a reminder that Prometheus is humanity’s best embodiment. My major hope for the new film is that Uhura does more than answer phones and/or smooch Kirk.

Coda: The Infinite Frontier

star-trekA younger science than physics, biology is more linear and less exotic than its older sibling. Whereas physics is (mostly) elegant and symmetric, biology is lunging and ungainly, bound to the material and macroscopic. Its predictions are more specific, its theories less sweeping. And yet, in the end, the exploration of life is the frontier that matters the most. Life gives meaning to all elegant theories and contraptions, life is where the worlds of cosmology and ethics intersect.

Continue reading “Forever Young” »

May 3, 2009

Swine Flu Update: are we entering an Age of Pandemics?

Posted by in categories: biological, biotech/medical, existential risks, futurism, geopolitics, nanotechnology, space, sustainability

May 2: Many U.S. emergency rooms and hospitals crammed with people… ”Walking well” flood hospitals… Clinics double their traffic in major cities … ER rooms turn away EMT cases. — CNN

Update May 4: Confirmed cases of H1N1 virus now at 985 in 20 countries (Mexico: 590, 25 deaths) — WHO. In U.S.: 245 confirmed U.S. cases in 35 states. — CDC.

“We might be entering an Age of Pandemics… a broad array of dangerous emerging 21st-century diseases, man-made or natural, brand-new or old, newly resistant to our current vaccines and antiviral drugs…. Martin Rees bet $1,000 that bioterror or bioerror would unleash a catastrophic event claiming one million lives in the next two decades…. Why? Less forest, more contact with animals… more meat eating (Africans last year consumed nearly 700 million wild animals… numbers of chickens raised for food in China have increased 1,000-fold over the past few decades)… farmers cut down jungle, creating deforested areas that once served as barriers to the zoonotic viruses…” — Larry Brilliant, Wall Street Journal


Apr 29, 2009

DIYbio.org

Posted by in categories: biological, biotech/medical, chemistry, education, engineering, ethics, human trajectories, open access, open source

About

DIYbio is an organization that aims to help make biology a worthwhile pursuit for citizen scientists, amateur biologists, and DIY biological engineers who value openness and safety. This will require mechanisms for amateurs to increase their knowledge and skills, access to a community of experts, the development of a code of ethics, responsible oversight, and leadership on issues that are unique to doing biology outside of traditional professional settings.

What is DIYbio in 4 minutes?

Get Involved

You can read about current events and developments in the DIYbio community by reading or subscribing to the blog.

Get in contact or get involved through discussions on our mailing list, or by attending or hosting a local DIYbio meetup.

The mailing list is the best way to find out what’s happening with DIYbio right now. There is also a low-traffic announce list.

Find out about our featured projects, including our plans for public wetlabs, global FlashLab experiments, and our innovation of next-gen lab equipment on the Projects page.

Apr 5, 2009

On Being Bitten to Death by Ducks

Posted by in categories: biological, complex systems, education, ethics, futurism, policy

(Crossposted on the blog of Starship Reckless)

Working feverishly on the bench, I’ve had little time to closely track the ongoing spat between Dawkins and Nisbet. Others have dissected this conflict and its ramifications in great detail. What I want to discuss is whether scientists can or should represent their fields to non-scientists.

There is more than a dollop of truth in the Hollywood cliché of the tongue-tied scientist. Nevertheless, scientists can explain at least their own domain of expertise just fine, even become major popular voices (Sagan, Hawkin, Gould — and, yes, Dawkins; all white Anglo men, granted, but at least it means they have fewer gatekeepers questioning their legitimacy). Most scientists don’t speak up because they’re clocking infernally long hours doing first-hand science and/or training successors, rather than trying to become middle(wo)men for their disciplines.

prometheus

Continue reading “On Being Bitten to Death by Ducks” »

Mar 12, 2009

Crowdsourced Women’s Health Books Released by CureTogether

Posted by in categories: biological, biotech/medical, information science, open access, open source

Over 300 Women Share Experiences, Treatments for Painful, Common Chronic Conditions

CureTogether, a Health 2.0 Startup based in Silicon Valley, has released the first crowdsourced books on vulvodynia and endometriosis: two common, poorly understood conditions causing daily pain for millions of women. Assembled from the input of 190 and 137 women living with these respective conditions, “Vulvodynia Heroes” and “Endometriosis Heroes” are the product of an ongoing online research study at http://www.curetogether.com.

“Patients came together and decided what symptoms and treatments they wanted to track. They went on to diligently gather detailed, quantitative data on their bodies and experiences,” said Alexandra Carmichael, co-Founder of CureTogether. “The hope of this book is to spread awareness, reach out to people in pain who may not have heard of endometriosis, and increase interest and funding for future research.”

“These heroes are pioneers not just in investigating their own condition, but in developing self-cure practices that others can follow.”, said Gary Wolf, Contributing Editor of Wired and Blogger at The Quantified Self. “Many other women who are suffering will find this very helpful and inspiring,” said Elizabeth Rummer, MSPT at the Pelvic Health and Rehabilitation Center in San Francisco. A patient with endometriosis added, “This is great. I am just starting to really appreciate what awesome power CureTogether can have.”

Endometriosis is a painful chronic condition that affects 5–10% of women, and vulvodyna affects up to 16% of women at some point in their lives. They are two of the most active condition communities at CureTogether, with information about symptoms, treatments, and causes added by over 300 women. The books are available at http://www.curetogether.com/VHeroes and http://www.curetogether.com/EHeroes.

Continue reading “Crowdsourced Women's Health Books Released by CureTogether” »