Lifeboat Foundation

The new research, led by nanoengineering professor Shaochen Chen, addresses one of the biggest challenges in tissue engineering: creating lifelike tissues and organs with functioning vasculature — networks of blood vessels that can transport blood, nutrients, waste and other biological materials — and do so safely when implanted inside the body.

Researchers from other labs have used different 3D printing technologies to create artificial blood vessels. But existing technologies are slow, costly and mainly produce simple structures, such as a single blood vessel — a tube, basically. These blood vessels also are not capable of integrating with the body’s own vascular system.

“Almost all tissues and organs need blood vessels to survive and work properly. This is a big bottleneck in making organ transplants, which are in high demand but in short supply,” said Chen, who leads the Nanobiomaterials, Bioprinting, and Tissue Engineering Lab at UC San Diego. “3D bioprinting organs can help bridge this gap, and our lab has taken a big step toward that goal.”

Continue reading “Nanoengineers 3D print biomimetic blood vessel networks” »

Researchers from the University of California, San Diego have successfully 3D printed a framework of functional blood vessels. Blood vessel networks are important in transporting blood, nutrients and waste around the human body.

The research team employed a 3D bioprinting process involving hydrogel and endothelial cells. Endothelial are the form of cells that make up the inner lining of blood vessels.

Leading the research was Shaochen Chen, who explains the motivation of the project.

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A 3D bioprinter able to create human skin is already being used to help burns patients and carry out skin testing, Alfredo Brisac, CEO of Spanish bioengineering company BioDan, told Radio Sputnik.

Last month, scientists at Universidad Carlos III de Madrid and the BioDan Group presented a prototype 3D bioprinter that can create human skin suitable for transplantation to patients or for use in cosmetic, chemical or pharmaceutical testing.

One of the first living human organs to be created using bioprinting, the 3D-printed skin is created using bio-inks with living cells that are deposited onto a structure that replicates nature. The bio-ink contains the key elements of keratinocytes, fibroblasts and fibrin, which can recreate the structure of the skin.

Scientists from the Universidad Carlos III de Madrid (UC3M), CIEMAT (Center for Energy, Environmental and Technological Research), Hospital General Universitario Gregorio Marañón, in collaboration with the firm BioDan Group, have presented a prototype for a 3D bioprinter that can create totally functional human skin. This skin is adequate for transplanting to patients or for use in research or the testing of cosmetic, chemical, and pharmaceutical products.

This research has recently been published in the electronic version of the scientific journal Biofabrication. In this article, the team of researchers has demonstrated, for the first time, that, using the new 3D printing technology, it is possible to produce proper human skin. One of the authors, José Luis Jorcano, professor in UC3M’s department of Bioengineering and Aerospace Engineering and head of the Mixed Unit CIEMAT/UC3M in Biomedical Engineering, points out that this skin “can be transplanted to patients or used in business settings to test chemical products, cosmetics or pharmaceutical products in quantities and with timetables and prices that are compatible with these uses.”

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Highly sophisticated robotics and ‘bio-printing’ are rapidly changing the face of modern surgery, significantly eliminating the risk of human error and in some cases even allowing doctors to perform procedures remotely, according to experts at Arab Health.

Dr Peter C.W. Kim, vice-president and associate surgeon-in-chief of the Joseph E. Roberts Jr. Centre for Surgical Care at Washington DC’s Children’s National — which has received millions of dollars in donations from the UAE’s government — noted that doctors will soon be able to 3D-print using bio-tissue, such as for an eardrum.

“What our engineers and researchers have done is not only design the plastic with it, but also graft cells onto it,” he said. “This is where we are going. You will (in the future) be able to have organs on the shelf. Instead of harvesting it, you can print it.”

Continue reading “Robots and bio-printing change the face of surgery in UAE” »

The annual 3D Bioprinting Conference is underway in the Netherlands today. While printing human body parts remains largely experimental, there are growing signs of commercial activity.

More progress for tissue engineering.

Skin is one of the easier starting points for 3D bioprinting, the application of rapid prototyping technologies to the construction of living tissue. Since skin is a thin tissue, the challenging issue of producing the intricate blood vessel networks needed to supply inner cells with oxygen and nutrients can be skipped. Thin tissue sections can be supported in a suitable nutrient bath, and after transplant, patient blood vessels will grow into the new skin. Further, there is a fairly large and long-established research and development industry involved in various forms of skin regeneration. Numerous forms of prototype skin-like tissues have been created over the years, lacking many of the features of the real thing, but still useful in the treatment of, for example, burn victims. Further, skin structure is by now well understood, and considerable progress has been made in deciphering the signals and environment needed for suitable cells to self-assemble into the correct arrangements. All told, it should not be a complete surprise to see significant progress emerge in this part of the field.

If you were to pick one emerging technology with the potential to have a massive positive impact on humanity in the coming years, there’s a good chance you’d go with 3D bioprinting.

The ability to use “bio-ink” to print out biomaterials ranging from heart tissues to bone and cartilage is incredibly exciting — although at present it’s not exactly the most user-friendly of tech.

One company hoping to change that is Cellink, which this week has announced the launch of its new Bio X printer, which it hopes will bring 3D bioprinting to a whole new audience.

Speculation on 3D printed tissue coming to humans sooner than we think is backed by new pre-clinical findings from 3D bioprinting company Organovo (NASDAQ: ONVO). Though it will still be 3 – 5 years before the U.S. based Organovo apply for clearance of their liver tissue, that is still sooner than perhaps even the FDA had in mind.

Pre-clinical trial data shows that 3D bioprinted liver tissue has been successfully planted into lab-bred mice. The human liver-cell tissue shows regular functionality and, at this stage, is being explored as a suitable patch for the organ.