Cancer therapy targeting acetylation and autophagy.
đĄ Liu, Y., Yan, Z., Fu, Z. et al. Cell Death Discov. 11, 522 (2025).
đĄ Liu, Y., Yan, Z., Fu, Z. et al. Crosstalk between acetylation modification and autophagy in cancer: roles: mechanisms and therapeutic potential. Acta Pharmacol Sin. 2024;46:816â28.
One of the worldâs most common viral infections could underlie virtually every case of lupus, according to a recent study providing the strongest evidence yet for a link.
The research, led by scientists at Stanford University, has found that the Epstein-Barr virus (EBV) could be the trigger behind the âcruel mysteryâ
EBV is the pathogen that causes âkissing diseaseâ (or mononucleosis), and according to the new findings, it can directly infect and reprogram specific immune cells, potentially driving the onset of the chronic autoimmune disease systemic lupus erythematosus â better known as simply lupus.
Damage in the bonding interface is a significant factor that leads to premature failure of dental bonded restorations. The imperfectly bonded dentin-adhesive interface is susceptible to hydrolytic degradation and bacterial and enzyme attack, severely jeopardizing restorationsâ longevity. Developing caries around previously made restorations, also called ârecurrent or secondary caries,â is a significant health problem. The replacement of restorations is the most prevailing treatment in dental clinics, leading to the so-called âtooth death spiralâ. In other words, every time a restoration is replaced, more tooth tissue is removed, increasing the size of the restorations until the tooth is eventually lost. This process leads to high financial costs and detriment to patientsâ quality of life.
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimerâs [1].
Which way to splice it?
Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final RNA transcript, and introns, which are thrown away.
The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with specialized functions. While CD4+ T cells support and modulate immune responses through different T-helper (Th) and regulatory subtypes, CD8+ T cells eliminate cells that might threaten the organism, for example, virus-infected or tumor cells. However, a paradoxical population of CD4+CD8+ double-positive (DP) T cells challenging this paradigm has been found in the peripheral blood. This subset has been observed in healthy as well as pathological conditions, suggesting unique and well-defined functions. Furthermore, DP T cells express activation markers and exhibit memory-like features, displaying an effector memory (EM) and central memory (CM) phenotype.
AGI Unbound Series.
A series of focused interviews with the most interesting and impactful thought leaders in the field. We press on first principlesâhow they define core ideas in their domain, how they see the present, and where they believe intelligence is headed. Brought to you by SingularityNET and the AGI Society.
About this interview â Joscha Bach.
In this kickoff episode, cognitive scientist Joscha Bach explores consciousness as a coherence-forming learning process, argues for a computational view of mind, and outlines why machine consciousness should be treated as a testable hypothesis rather than a slogan. He discusses the California Institute for Machine Consciousness, contrasts todayâs âidiot-savantâ AI with developmental intelligence, sketches futures from universal basic intelligence to post-human infospheres, and offers frank advice to new researchers on pursuing bold, technically grounded work.
#AGI #AI #Consciousness #SingularityNET #AGISociety #JoschaBach #DecentralizedAGI
SingularityNET was founded by Dr. Ben Goertzel with the mission of creating a decentralized, democratic, inclusive, and beneficial Artificial General Intelligence (AGI). An AGI is not dependent on any central entity, is open to anyone, and is not restricted to the narrow goals of a single corporation or even a single country.
The SingularityNET team includes seasoned engineers, scientists, researchers, entrepreneurs, and marketers. Our core platform and AI teams are further complemented by specialized teams devoted to application areas such as finance, robotics, biomedical AI, media, arts, and entertainment.
Researchers at The University of Texas MD Anderson Cancer Center have uncovered unexpected traces of bacteria within brain tumors. This discovery offers new insights into the environment in which brain tumors grow and sets the stage for future studies seeking to improve treatment outcomes.
Published today in Nature Medicine, the data revealed that bacterial genetic and cellular elements were present inside brain tumor cells and across the tumor microenvironment. These bacterial components appeared biologically active, potentially influencing tumor behavior and progression in patients with gliomas and brain metastases.
The multi-institutional study was led by Golnaz Morad, D.D.S, Ph.D., postdoctoral research fellow in Surgical Oncology, and Jennifer Wargo, M.D., professor of Surgical Oncology and Genomic Medicine and core member of the James P. Allison Instituteâworking in close collaboration with MD Andersonâs Platform for Innovative Microbiome and Translational Research (PRIME-TR).
They also used a recently validated map of deep brain areas. This in vivo atlas, Brainstem Navigator, maps the regions involved in regulating the autonomic, immune and endocrine systems.
The authors analytic approach was guided by decades of basic research that has identified two main brain pathways in mammals: one set of pathways (allostatic) that sends signals from the brain to control the bodyâs organs, and the other set (interoceptive) that sends signals from the body to the brain, informing it about whatâs happening inside us.
The findings replicated and expanded on their previous 3 Tesla work, confirming nearly all the direct connections identified in non-human mammals: 100% of those between cortical areas and 96% of those linking subcortical areas to both cortical and other subcortical areas. As expected, the authors found two-way connections between the brain areas that help manage the bodyâs needs (like the anterior cingulate cortex) and the areas that sense whatâs happening inside the body (like the posterior insula). This means these regions communicate back and forth, helping the brain predict and regulate what the body needs.
Mounting evidence suggests that one of the brainâs central roles is to anticipate and meet the bodyâs energy needs. The findings place the monitoring and regulation of the bodyâs needs at the functional core of the human brain, showing the close connection between mental and physical health.
Previous studies in both animal models and humans have pointed to the existence of a distributed system in the brain that helps it anticipate and prepare for the bodyâs energy needs â a process called allostasis â as well as monitor the sensory conditions inside the body, known as interoception.
In an earlier study using 3 Tesla fMRI, the team mapped a network supporting allostasis and interoception in the human brain, but the comparatively limited spatial resolution and sensitivity of the 3 Tesla technology made it difficult to fully capture the systemâs smaller structures in the brainstem, which are known to play a key role in these processes.