Lifeboat Foundation

Glue can stick to wet surfaces and form a seal within 15 seconds.

A team of researchers may have found an antibody that can neutralize all known novel coronavirus strains, including the developing variants.

GlaxoSmithKline and Vir Biotechnology recently conducted a huge collaborative study by scientists and developed a new antibody therapy, called Sotrovimab. During the project, they discovered a new natural antibody “that has remarkable breadth and efficacy,” according to the Berkeley Lab.

The scientists reportedly discovered a new antibody, called S309, which “neutralizes all known SARS-CoV-2 strains — including newly emerged mutants that can now ‘escape’ from previous antibody therapies — as well as the closely related original SARS-CoV virus,” according to a press release from the Berkeley Lab.

Favorite part at 19:06, Bioinformatics with Rutgers University attacking the hallmarks of aging.

#genetherapy, #immortality, #bioinformatics.

Continue reading “Seeking Immortality Through Gene Therapy — with Liz Parrish /Awesome Health Podcast” »

Pioneering mouse study offers new therapeutic avenues for reducing visceral fat stores, which have been associated with cardiovascular disease and multiple types of cancer.

Obesity has been linked to no less than 13 cancers, including the two most prevalent (breast and colorectal), as well as to cardiovascular disease, which remains a leading cause of death worldwide.

The most harmful type of obesity is caused by the excessive accumulation of so-called “deep” fat. Contrary to fat stores located directly under the skin, deep, or “visceral,” fat stores reside inside our abdominal cavity, where they envelop vital organs. In normal amounts, visceral fat supports various fundamental functions, such as reproduction. However, when it is too abundant, it produces unhealthy levels of proteins and hormones that negatively affect neighboring tissues and organs.

Nad plus works for alzheimers.

In June of 2,018 the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.¹ The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.^2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.⁴

Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.⁵ In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”⁶ Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.^7,8

By middle age, our NAD+ levels have plummeted to half that of our youth.⁹ Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.^10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).^12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.⁶.

The global revenue of the pharmaceutical market is 1.2 trillion dollars. With such capital at stake and with the pace of technological disruption, the pharma industry has to embrace new technologies, therapies, and innovations and put a greater focus on prevention and digital health.

In this video, we take a dive into the five trends of how big pharma will adapt to these changing times:

Continue reading “5 Things Big Pharma Can Expect from the 2020s / Episode 13 — The Medical Futurist” »

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Papers referenced in the video:
Human microbiome: an academic update on human body site specific surveillance and its possible role.
https://pubmed.ncbi.nlm.nih.gov/32524177/

Continue reading “Which Gut Bacteria Are Associated With Poor Health, And How Can We Limit Them?” »

A new coronavirus variant, C.1.2, has been detected in South Africa and a number of other countries, with concerns that the variant could be more infectious and evade vaccines, according to a new preprint study by South Africa’s National Institute for Communicable Diseases and the KwaZulu-Natal Research Innovation and Sequencing Platform. The study is awaiting peer review.

The C.1.2 variant first detected in South Africa is more mutated compared to the original virus than any other known variant.

Article at gnews reports on announcement by Dr. Ozaki, chairman of the Tokyo Metropolitan Medical Association Greenlight for Ivermectin in Japan. Excerpts in italics with my bolds.

Since Tokyo summer Olympic Game ended on August 8 2021, the urgent status of the pandemic as Japan is now in its worst surge of the COVID-19 pandemic since the onset of the crisis in such a megacity of 14 million. Most recently, a record number of new cases were reported at 20,140 on August 14. Deaths aren’t as high as successive waves of the pandemic from February2021to the end of May, but nerves are frayed with record numbers of infections. Dr. Ozaki, The chairman of the Tokyo Metropolitan Medical Association, recently led an emergency press conference on August 13 Dr. Haruo Ozaki shared those 18,000 new infections are reported daily. However, the death count has eased as compared to previous surges.

How to deal with the current dilemma is a huge challenge to Japanese government and medical agencies? Fortunately, India has an excellent testimonial. Since April 28 India medical officials started providing Hydroxychloroquine and ivermectin to its massive population. As India is the major pharmaceutical manufacture in the world, they were ready for this massive drug distribution. Miraculously, COVID cases have plummeted quickly since then thanks to the new rules.