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Pain management is an important component of caring for adults with cerebral palsy. However, it’s the least understood comorbidity in the adult cerebral palsy population.
A study led by Mark Peterson, Ph.D., M.S., FACSM, a professor of physical medicine and rehabilitation at University of Michigan Health, found that adults living with cerebral palsy had a very high occurrence of pain, with 90% having a pain history and 74% having multiple diagnoses of pain coming from different origins such as the lower back, irritable bowels, joint arthritis and chronic headaches.
The research is published in the journal JAMA Neurology.
Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children’s Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.
The preclinical findings were published in the journal Proceedings of the National Academy of Sciences.
Last year, a multi-institutional consortium of researchers found that the genes of the mitochondria, the energy producers of our cells, can be negatively impacted by the virus, leading to dysfunction in multiple organs beyond the lungs.
Researchers develop TADPOLE, an enzyme-free black phosphorus quantum dot system for site-specific DNA cleavage using light, offering advantages over traditional methods.
Strengthening Public Health Systems For Healthier And Longer Lives — Dr. Ashwin Vasan, Commissioner, NYC Department of Health and Mental Hygiene.
Dr. Ashwin Vasan, MD, PhD is the Commissioner of the New York City Department of Health and Mental Hygiene (https://www.nyc.gov/site/doh/about/ab…).
This is because the species undergoes a process called polyploidization, which is when a single chromosome is duplicated multiple times.
“It has amazing genetic diversity,” study co-author Tim O’Hara, a senior marine curator at Museums Victoria in Australia, told Newsweek.
“Instead of evolving into separate species over time, lineages readily hybridize with each other, so building up a great amount of genetic diversity. But not only that, they sometimes add their genomes together, so end up with four or more copies of each gene,” O’Hara said.
We’re living in an aging society with cognitive loss placing stress on caregivers to monitor older adults struggling with memory decline.
MemPal is a wearable voice-based memory assistant that helps older adults live more independently and safely at home while also reducing caregiver burden. MemPal uses AI to automatically log the user’s actions in real-time based on visual context from a wearable camera without storing any image data, thereby preserving user privacy. With this activity log, MemPal helps older adults recall locations of misplaced objects and completion of past actions using simple voice-based queries such as “Hey Pal, where is my phone?” Additionally, MemPal provides context-based proactive safety reminders (e.g., “you may have forgotten to turn off the stove” or” you already took your medicine an hour ago”) and automatically tracks the completion on the MemPal app, allowing for remote monitoring by caregivers. Lastly MemPal can generate an automatic, summarized diary of activities for caregivers that may also prove useful for physicians to better understand patient behavior within their home.
MemPal was tested within the homes of 15 older adults (ages 65+). Our study demonstrated improved performance of object finding with audio-based assistance compared to no aid and positive overall user perceptions on the designed system. We discuss future design guidelines to adapt these types of wearable systems to various older adults’ needs.
But the technology for using bridge RNA in genome editing is still in the early stages. Hsu’s team has demonstrated this system only in bacteria, though Hsu says he is optimistic that efforts to adapt the approach to work in mammalian cells will succeed. Chen says this system’s efficiency may not be as good as CRISPR’s is now but that improvements will come with time.
Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer’s disease. Leveraging single-cell Merfish spatial transcriptomics technology, the team was able to profile the effects of the mutation across multiple cortical and subcortical brain regions, offering first-of-their-kind insights at the single-cell level.
The study, published in Molecular Psychiatry, compared the brains of normal mice and special mouse models that undergo changes like those in humans with Alzheimer’s.
Findings revealed that the TREM2 mutation led to divergent patterns of beta-amyloid plaque accumulation in various parts of the brain involved in higher-level functions such as memory, reasoning and speech. It also affected certain cell types and their gene expression near the plaques.
With the first CRISPR–Cas9 gene therapy now approved, scientists are turning to newer editing technologies to produce safer, faster and better treatments for genetic diseases.
