Lifeboat Foundation

A UCSF study reveals that higher inflammation levels in young adults are associated with poorer cognitive performance in midlife, underscoring the importance of lifestyle choices in reducing inflammation and preventing cognitive decline.

Higher levels of inflammation in young adults, associated with factors like obesity, physical inactivity, chronic illness, stress, and smoking, are linked to decreased cognitive function in midlife, according to a new study from UC San Francisco.

Researchers previously linked higher inflammation in older adults to dementia, but this is one of the first studies to connect inflammation in early adulthood with lower cognitive abilities in midlife.

Researchers have discovered a new pathway used by cancer cells to infiltrate the brain and developed a promising therapy that targets this pathway with CAR T cells.

Their study showed significant preclinical success in increasing survival and eradicating tumors in animal models of glioblastoma and other brain cancers.

A team of Canadian and American research groups led by the Singh Lab at McMaster University have discovered a new pathway that is used by cancer cells to infiltrate the brain. The research also reveals a new therapy that shows promise in blocking and killing these tumors.

All-optical multiplane quantitative phase imaging design eliminates the need for digital phase recovery algorithms.

UCLA researchers have introduced a breakthrough in 3D quantitative phase imaging that utilizes a wavelength-multiplexed diffractive optical processor to enhance imaging efficiency and speed. This method enables label-free, high-resolution imaging across multiple planes and has significant potential applications in biomedical diagnostics, material characterization, and environmental analysis.

Introduction to Quantitative Phase Imaging.

When we form a new memory, the brain undergoes physical and functional changes known collectively as a “memory trace.” A memory trace represents the specific patterns of activity and structural modifications of neurons that occur when a memory is formed and later recalled.

But how does the brain “decide” which neurons will be involved in a memory trace? Studies have suggested that the inherent excitability of neurons plays a role, but the currently accepted view of learning has neglected to look inside the command center of the neuron itself, its nucleus. In the nucleus, there seems to be another dimension altogether that has gone unexplored: epigenetics.

Inside every cell of a given living organism, the genetic material encoded by the DNA is the same, yet the various cell types that make up the body, like skin cells, kidney cells, or nerve cells each express a different set of genes. Epigenetics is the mechanism of how cells control such gene activity without changing the DNA sequence.

Microwave technology has dramatically progressed, marked by the arrival of the 5G era, owing to the advantages of electromagnetic waves in long-distance, wireless, and high-speed transmissions. However, electromagnetic wave pollution problems such as electromagnetic wave interference and electromagnetic wave radiation are becoming increasingly serious.

Electromagnetic wave pollution not only affects the normal operation of electronic equipment, greatly threatens the information security of the scientific community, but also endangers human health and is a possible cause of cancer and sensitized diseases.

SiOC precursor ceramics have great application potential in electromagnetic protection because of their advantages such as lightweight, high-temperature resistance, and molecular designability. The main challenge of polymer-derived ceramic-based composites for electromagnetic wave absorption is the single loss mechanism, resulting in inferior electromagnetic wave attenuation ability.

I like what Fahy says here most.

RAADfest is the largest and most immersive event in the world focused on super-longevity for a general audience. Bringing together cutting-edge science, inspiration, entertainment and fun, RAADfest is more than just a conference – it’s a celebration of life. From brain longevity and sexual health, to senolytics, personalized medicine and helping your pets live longer too, RAADfest provides the information and inspiration to enable people to take charge of their longevity.

Continue reading “RAADfest 2024: An Early Preview” »

I have a new essay out via the wonderful site Merion West. The article is based on some of my experimental writings at Oxford. I hope you’ll read and consider it. I’m highly worried life extension science isn’t moving forward fast enough!

“Sadly, biological humans are likely to be mortal for centuries more, unless a dramatic increase of both resources and life extension scientists are marshaled.”

Certain well-known gerontologists and longevity experts around the world believe that sometime in this century—probably in the next 15–50 years—medicine will likely overcome and cure most forms of disease, and even death itself. Billionaires such as Meta’s Mark Zuckerberg, Amazon’s Jeff Bezos, Alphabet’s Larry Page, and Oracle’s Larry Ellison have jumped on board, pledging billions of dollars to “conquering all disease by this century” and mortality altogether.

Continue reading “When We’re Overly Optimistic about the Pace of Life Extension Research” »

An international team of scientists, led by Trinity College Dublin, has devised an innovative imaging method using state-of-the-art microscopes that significantly reduces the time and radiation required. Their work represents a significant breakthrough that will benefit several disciplines, from materials science to medicine, as the method promises to deliver improved imaging for sensitive materials such as biological tissues that are especially vulnerable to damage.

It sounds like science fiction, but many scientists believe editing the human genome is key to our advancement across the solar system.