Lifeboat Foundation

Just as plastic tips protect the ends of shoelaces and keep them from fraying when we tie them, molecular tips called telomeres protect the ends of chromosomes and keep them from fusing when cells continually divide and duplicate their DNA. But while losing the plastic tips may lead to messy laces, telomere loss may lead to cancer.

Salk Institute scientists studying the relationship of telomeres to cancer made a surprising discovery: a cellular recycling process called autophagy—generally thought of as a survival mechanism—actually promotes the death of cells, thereby preventing cancer initiation.

The work, which appeared in the journal Nature on January 23, 2019, reveals autophagy to be a completely novel tumor-suppressing pathway and suggests that treatments to block the process in an effort to curb cancer may unintentionally promote it very early on.

Continue reading “In surprising reversal, scientists find a cellular process that stops cancer before it starts” »

A newly designed set of nanorobots could be the key to implementing a new global structure of administering medication using nanobots.

Continue reading “Ingestible Nanobots To Start Delivering Drugs Into Blood Vessels” »

Food additives known as dietary emulsifiers, commonly found in processed foods to improve texture and extend shelf life, may adversely affect anxiety-related and social behaviors in mice, Georgia State researchers have found.

The scientists also observed sex differences in the mice’s behavioral patterns, suggesting that emulsifiers affect the brain via distinct mechanisms in males and females.

The study, published in Scientific Reports, was led by Geert de Vries, professor of neuroscience and associate vice president for research at Georgia State, and Benoit Chassaing, assistant professor of neuroscience. Andrew T. Gewirtz, professor in the Institute for Biomedical Sciences, also contributed.

Continue reading “Common Food Additives May Promote Anxiety-Related Behavior In Mice” »

Last year, the FDA announced a whole bunch of recalls related to blood pressure medication over fears that an impurity created during the manufacturing process could lead to cancer. The compound in question was found in dozens of prescription medications that contained the active ingredient valsartan, prompting several distributors and manufacturers to issue voluntary recalls affecting countless heart patients.

Now, additional medications containing a similar blood pressure drug, irbesartan, have been found to contain the same impurity, and a new round of recalls is upon us. Solco Healthcare LLC is now asking anyone with potentially contaminated medication to stop taking the drug.

A large meta-study from a team of UK researchers has examined data from over a dozen different clinical trials to conclude that the dangers of daily aspirin use may outweigh any potential benefits for individuals that are generally healthy.

A Chinese scientist who created what he said were the world’s first “gene-edited” babies evaded oversight and broke ethical boundaries in a quest for fame and fortune, state media said on Monday, as his former university said he had been fired.

He Jiankui said in November that he used a gene-editing technology known as CRISPR-Cas9 to alter the embryonic genes of twin girls born that month, sparking an international outcry about the ethics and safety of such research.

Hundreds of Chinese and international scientists condemned He and said any application of gene editing on human embryos for reproductive purposes was unethical.

Continue reading “Chinese scientist who gene-edited babies fired” »

Researchers from the Netherlands Institute for Neuroscience (NIN) and the Leiden University Medical Center (LUMC) have shown that treatment using gene therapy leads to a faster recovery after nerve damage. By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated for the first time. The discovery, published in the journal Brain, is an important step towards the development of a new treatment for people with nerve damage.

During birth or following a traffic accident, nerves in the neck can be torn out of the spinal cord. As a result, these patients lose their arm function, and are unable to perform daily activities such as drinking a cup of coffee. Currently, surgical repair is the only available treatment for patients suffering this kind of nerve damage. “After surgery, nerve fibers have to bridge many centimeters before reaching the muscles and nerve cells from which new fibers need to regenerate are lost in large numbers. Most regenerating nerve fiber do not reach the muscles. The recovery of arm function is therefore disappointing and incomplete,” explains researcher Ruben Eggers of the NIN.

2019 will likely see gene drives used in the wild, a universal flu vaccine, further advance of brain-machine interfaces, and more.

With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to turn those answers into practical ways to extend our healthspan.

Here, in Part 2 of a series of blogs on Longevity & Vitality, I explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

In this blog I’ll cover two classes of emerging technologies:

Continue reading “Longevity & Vitality Part 2: A Renaissance of Drugs and Genomics” »