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Category: biotech/medical – Page 1,295

New neuroscience research sheds light on why anxiety tends to diminish with age

As people get older, they tend to have lower levels of anxiety. But why? A new brain imaging study has found that older individuals are faster at recognizing and responding to negative emotions. The findings, published NeuroImage, go against the idea that older adults are less engaged with negative emotions due to cognitive decline or that they are better at regulating negative emotions. Instead, the results suggest that older adults may develop a more automatic way of processing negative emotions.

The study aimed to investigate the relationship between aging, trait anxiety, and changes in cognitive and affective functions. The researchers were motivated by previous findings that older adults tend to have lower susceptibility to anxiety disorders compared to younger and middle-aged adults. However, it was not clear how age-related changes in anxiety symptoms, such as worry and somatic symptoms, were related to changes in cognitive and affective processes.

“We are interested in emotion dysfunction in early dementia, including those people with subjective complaints of memory problem and mild cognitive impairment,” said study author Chiang-shan Ray Li, a professor of psychiatry and neuroscience at Yale University School of Medicine.

Eliminating Death Doesn’t Mean Life Will Get Boring

In my new Newsweek Op-Ed, I tackle a primary issue many people have with trying to stop aging and death via science. Hopefully this philosophical argument will allow more resources & support into the life extension field:

Philosophers often say if humans didn’t die, we’d be bored out of our minds. This idea, called temporal scarcity, argues the finitude of death is what makes life worth living. Transhumanists, whose most urgent goal is to use science to overcome biological death, emphatically disagree.

For decades, the question of temporal scarcity has been debated and analyzed in essays and books. But an original idea transhumanists are putting forth is reinvigorating the debate. It doesn’t discount temporal scarcity in biological humans; it discounts it in what humans will likely become in the future—cyborgs and digitized consciousnesses.

The traditional temporal scarcity argument against immortality imagines the human being remaining biologically the same as it has for tens of thousands of years. Yet the human race is already augmenting the human body with radical technology. Globally, over 200,000 people already have brain implants, and Silicon Valley companies like Elon Musk’s Neuralink are working on trying to get millions of us to become cyborgs.

A growing number of experts even believe by the end of the century, humans will likely have the ability to upload the brain and its consciousness into a computer. In the process, digitized people will overcome biological death and engage in far more complex ways of being, including grand new designs of consciousness and selfhood.

Chinese researchers claim they can synthesize tonal speech using neural cues

The research is a result of observations from awake language mapping during brain tumor surgery.

A team of Chinese researchers has developed a way to artificially produce speech, also known as speech synthesis, using cues from neural brain activity.

According to the South China Morning Post, the researchers claim that they have a mind-reading machine that is capable of turning human thought into spoken Mandarin.

Psychedelics Unlock Learning Windows in the Brain

Summary: Researchers discovered a unique property of psychedelic drugs: their ability to reopen “critical periods” in the brain, times when the brain is highly susceptible to environmental learning signals. These periods, usually associated with skills development like language learning, are reopened by psychedelics for different lengths of time.

This breakthrough in understanding psychedelic drug function may have therapeutic implications for conditions like stroke and deafness. Further, it uncovers novel molecular mechanisms influenced by psychedelics.

Video Game Algorithm Unlocks Molecular Mysteries of Brain Cells

Summary: Researchers leveraged a tracking algorithm from video games to study molecules’ behavior within live brain cells.

They adapted the fast and accurate algorithm used to track bullets in combat games for use in super-resolution microscopy. The innovative approach enables scientists to observe how molecules cluster together to perform specific functions in space and time within the brain cells.

The data obtained could shed light on molecular functions’ disruption during aging and disease.

Healthcare Robot with ‘Sense of Touch’ Could Reduce Infection Spread

A first-of-its-kind robot which gives clinicians the ability to ‘feel’ patients remotely has been launched as part of a Finnish hospital pilot by deep tech robotics company Touchlab, a new tenant of the world-leading centre for robotics and artificial intelligence the National Robotarium.

Controlled by operators wearing an electronic haptic glove, the Välkky telerobot is equipped with the most advanced electronic skin (e-skin) technology ever developed to transfer a sense of touch from its robotic hand to users. E-skin is a material which is made up of single or multiple ultra-thin force sensors to transmit tactile sensations like pressure, vibration or motion from one source to another in real-time.

The 3-month pilot at Laakso Hospital in Helsinki, Finland will see a team of purpose-trained nurses explore how robotics systems can help deliver care, reduce workload and prevent the spread of infections or diseases. The pilot at Laakso Hospital is coordinated by Forum Virium Helsinki, an innovation company for the City of Helsinki. The research is part of a wider €7 billion project aimed at developing the most advanced hospital in Europe, due to be completed in 2028.

How often should I get a colonoscopy?

Getting a colonoscopy is important to screen for colorectal cancer. But how often you should get a colonoscopy depends on several different factors.

Current guidelines suggest that you get your first colonoscopy at age 45 if you are at average risk for colorectal cancer. If no polyps are found, you won’t need another colonoscopy for another 10 years. But in certain situations, you may need a colonoscopy more often.

We spoke with gastroenterologist Mazen Alasadi, M.D., to learn more.

Dr Brandon Berry, PhD — Exploring Mitochondrial Bioenergetics, Optogenetics, Human Health And Aging

Exploring Mitochondrial Bioenergetics, Optogenetics, Human Health And Aging — Dr. Brandon Berry, Ph.D., University of Washington.

Dr. Brandon Berry, Ph.D. (https://halo.dlmp.uw.edu/people/brandon-berry/) is a postdoctoral researcher in the Kaeberlein Laboratory at University of Washington where his research focuses on how aging and metabolism are linked.

Dr. Berry is interested in how mitochondria, the powerhouses of cells, contribute to and modulate functional decline that occurs during aging, and he is involved in using novel tools, like optogenetics, to precisely control mitochondria and metabolism with light. Through these types of experiments, he can more precisely determine if mitochondrial dysfunction is a cause or a consequence of metabolic aging and may reveal new ways to understand and impact health.

Dr. Berry has BS in Biochemistry from SUNY Geneseo, and an MS and PhD in Physiology from University of Rochester.

How to bring back the dead

Here’s my new article for Aporia Magazine. A lot of wild ideas in it. Give it a read:

Regardless of the ethics and whether the science can even one day be worked out for Quantum Archaeology, the philosophical dilemma it presents to Pascal’s Wager is glaring. If humans really could eradicate the essence of death as we know it—including even the ability to ever permanently die—Pascal’s Wager becomes unworkable. Frankly, so does my Transhumanist Wager. After all, why should I dedicate my life and energy to living indefinitely through science when, by the next century, technology could bring me back exactly as I was—or even as an improved version of myself?

Outside of philosophical discourse, billions of dollars are pouring into the anti-aging and technology fields—much of it from Silicon Valley and the San Francisco Bay Area where I live. Everyone from entrepreneurs like Mark Zuckerburg to nonprofits like XPRIZE to giants like Google is spending money on ways to try to end all diseases and overcome death. Bank of America recently reported that they expect the extreme longevity field to be worth over $600 billion dollars by 2025.

Technology research spending for computers, microprocessors, and information technology is even bigger: $4.3 trillion dollars is estimated to have been spent worldwide in 2019. This amount includes research into quantum computing, which is hoped to eventually make computers hundreds—maybe thousands—of times faster over the next 50 years.

Despite the advancements of the 21st Century, the science to overcome biological death is not even close to being ready, if ever. Over 100,000 people still die a day, and in some countries like America, life expectancy has actually started going slightly backward. However, like other black swans of innovation in history—such as the internet, combustion engine, and penicillin—we shouldn’t rule out that new inventions may make humans live dramatically longer and maybe even as long as they like. As our species reaches for the heavens with its growing scientific armory, Pascal’s Wager is going to be challenged. It just might need an upgrade.

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