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FRIDAY, July 1, 2016 (HealthDay News) — Electrical pulses to the brain may help restore vision in some partially blind patients, German researchers report.

Glaucoma and other types of damage to the eye’s optic nerve typically cause permanent damage. But, the new technique appears to kick-start the brain’s visual control centers, the researchers explained.

A 10-day treatment regimen — entailing upwards of nearly an hour a day of electrical pulses aimed directly into the eye — improved vision among patients who were losing their sight, the researchers said.

Continue reading “Could ‘Zaps’ to the Brain Help Fight Glaucoma?” »

Games to help fight obesity?

Innovative research uses technology to help people with a sweet-tooth lose weight. Researchers believe they can train the brain to better resist temptation and warn people of an unhealthy urge before the temptation occurs.

Specifically, Drexel University psychologists have created a computer game aimed at improving users’ inhibitory control. Additionally, the investigators are also rolling out a mobile app that used in conjunction with the Weight Watchers app, will alert users on unhealthy urges before they strike.

Continue reading “New Gaming Software Hopes to Train Brain to Resist Sweets” »

But those don’t address the electrical circuitry at work in the brain, which scientists hope will provide a more precise option for treatment.

“We’ve focused a lot on the chemical side, because in the mid-20th century, we began to develop the first medications that affected neurotransmitters,” said Dr. Darin Dougherty, director of the division of neurotherapeutics and the department of psychiatry at Massachusetts General Hospital. “The other side, the electrical, that’s been less exploited as a treatment potential.”

Dougherty and others are working to change that. With funding from the Defense Advanced Research Projects Agency, or DARPA, scientists are working to build new ways to treat psychiatric disorders, like PTSD, through deeper understandings of the electrical signals in our brains.

Continue reading “Treating psychiatric disorders through neuron stimulation” »

A light-activated injectable device that could eventually be used to stimulate nerve cells and manipulate the behavior of muscles and organs has been developed.

Investigators at Dana-Farber Cancer Institute in collaboration with scientists at the University of California, Berkeley, have identified a natural molecular pathway that enables cells to burn off calories as heat rather than store them as fat. This raises the possibility of a new approach to treating and preventing obesity, diabetes, and other obesity-linked metabolic disorders including cancer.

Reporting in an online publication by the journal Cell, scientists led by Bruce Spiegelman, PhD, director of the Center for Energy Metabolism and Chronic Disease at Dana-Farber, and professor of cell biology and medicine at Harvard Medical School, discovered the mechanism in energy-burning brown and beige fat cells in mice. They identified an enzyme, PM20D1, which is secreted by the cells and triggers the production of compounds called N-acyl amino acids. These N-acyl amino acids “uncouple” fat burning from other metabolic processes, allowing for weight loss. Such “uncouplers” were known as synthetic chemicals but this is the first known natural small molecule with uncoupling activity.

When they injected the N-acyl amino acids into obese mice which ate a high-fat diet, the researchers noted significant weight loss after eight days of treatment. The weight loss was entirely in fatty tissue.

Continue reading “Researchers identify calorie-burning pathway in fat cells” »

A Belgian hospital is experimenting with robot “employees”.

One of the biggest challenges in treating brain cancer has been getting drugs to cross the blood-brain barrier and attack tumours where they’re needed.

But scientists say they’ve now developed a truly soluble liquid aspirin that can make its way into the brain, and, in the lab at least, kill cancerous glioblastoma cells without harming healthy brain tissue.

The research hasn’t been published in a peer-reviewed journal as yet, so we need to take it with a big pinch of salt for now. But scientists from the Brain Tumour Research Centre at the University of Portsmouth in the UK just presented it at the Brain Tumours 2016 conference in Poland.

Continue reading “Scientists say they’ve developed aspirin that crosses the blood-brain barrier” »

3D printing has has a presence in the medical industry since the 1980s for modelling body parts that are otherwise untouchable without invasive surgery, but research into the potential of this technology is bringing clinicians closer to getting a good look up close at the real thing. Instead of scans, what about injecting a camera no bigger than a grain of salt into your patient?

A group of German researchers have been working on a complex lens system that is small enough to fit inside a syringe, and applications aren’t just limited to the medical industry. They have the potential to also be used in many products which need parts to be as small and light as possible, such as drones and smart phones.

Continue reading “Tiny 3D Printed Cameras with Enormous Potential” »

Two interconnected brain areas — the hippocampus and the entorhinal cortex — help us to know where we are and to remember it later. By studying these brain areas, researchers at Baylor College of Medicine, Rice University, The University of Texas MD Anderson Cancer Center and the National Cancer Institute have uncovered new information about how dysfunction of this circuit may contribute to memory loss in Alzheimer’s disease. Their results appear in Cell Reports.

“We created a new mouse model in which we showed that spatial memory decays when the entorhinal cortex is not functioning properly,” said co-corresponding author Dr. Joanna Jankowsky, associate professor of neuroscience at Baylor. “I think of the entorhinal area as a funnel. It takes information from other sensory cortices — the parts of the brain responsible for vision, hearing, smell, touch, and taste — and funnels it into the hippocampus. The hippocampus then binds this disparate information into a cohesive memory that can be reactivated in full by recalling only one part. But the hippocampus also plays a role in spatial navigation by telling us where we are in the world. These two functions converge in the same cells, and our study set out to examine this duality.”

The new mouse model was genetically engineered to carry a particular surface receptor on the cells of the entorhinal cortex. When this receptor was activated by administering the drug ivermectin to the mice, the cells of the entorhinal cortex silenced their activity. They stopped funnelling information to the hippocampus. This system allowed the scientists to turn off the entorhinal cortex, and to determine how this affected hippocampal function.

Continue reading “A new experimental system sheds light on how memory loss may occur” »