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Category: biotech/medical – Page 1,314

X-Ray Of A Single Atom Achieved In World First

Thinking of X-rays might trigger memories of broken bones or dental check-ups. But this extremely energetic light can show us more than just our bones: it is also used to study the molecular world, even biochemical reactions in real-time. One issue, though, is that researchers have never been able to study a single atom with X-rays. Until now.

Scientists have been able to characterize a single atom using X-rays. Not only were they able to distinguish the type of atoms they were seeing (there were two different ones), but they also managed to study the chemical behavior these atoms were showing.

“Atoms can be routinely imaged with scanning probe microscopes, but without X-rays, one cannot tell what they are made of. We can now detect exactly the type of a particular atom, one atom-at-a-time, and can simultaneously measure its chemical state,” senior author Professor Saw Wai Hla, from the University of Ohio and the Argonne National Laboratory, said in a statement.

Scientists Uncover a Surprising Link Between Pure Mathematics and Genetics

An interdisciplinary team of mathematicians, engineers, physicists, and medical scientists has discovered a surprising connection between pure mathematics and genetics. This connection sheds light on the structure of neutral mutations and the evolution of organisms.

Number theory, the study of the properties of positive integers, is perhaps the purest form of mathematics. At first sight, it may seem far too abstract to apply to the natural world. In fact, the influential American number theorist Leonard Dickson wrote “Thank God that number theory is unsullied by any application.”

And yet, again and again, number theory finds unexpected applications in science and engineering, from leaf angles that (almost) universally follow the Fibonacci sequence, to modern encryption techniques based on factoring prime numbers. Now, researchers have demonstrated an unexpected link between number theory and evolutionary genetics.

Omicron variant resembles other respiratory viruses, posing challenges for syndromic surveillance

In a recent article published in Scientific Reports, researchers describe the symptom profiles of respiratory viral infections from the Flu Watch Community and the Virus Watch cohort studies to compare the frequency of the range of symptoms experienced during influenza, respiratory syncytial virus (RSV), rhinovirus, seasonal coronaviruses (CoVs) infections, and infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wild-type (wt) strain and variants of concerns (VOCs), including Alpha, Delta, Omicron BA1/BA2/BA5.

Study: Symptom profiles of community cases infected by influenza, RSV, rhinovirus, seasonal coronavirus, and SARS-CoV-2 variants of concern. Image Credit: KitjaKitja/Shutterstock.com.

Nutrition meets cancer therapy: How gut microbiome and diet impact immunotherapy success

In a recent review published in BJC reports, researchers investigated the complex relationship between gut bacteria, diet, and patient nutrition, aiming to discern how these combined elements impact responses to immune checkpoint inhibitor (ICI) cancer treatment and identify patients most likely to benefit from such therapy.

Study: Gut microbiome and nutrition-related predictors of response to immunotherapy in cancer: making sense of the puzzle. Image Credit: SewCreamStudio/Shutterstock.com.

Can senotherapeutic peptides reduce skin aging?

The skin is the largest organ of the body, comprising several compartments and about 20 different cell types that are involved in various skin functions – complexity that is more than skin deep! [1] Skin aging is a multifactorial process that is impacted by several intrinsic and extrinsic factors. Constant exposure of the human skin to such stimuli impacts its function and accelerates aging resulting in dry skin, wrinkling, thinning of the epidermis, and reduced barrier integrity. While we notice most of those changes by looking in a mirror – something the cosmetics industry has leveraged to multi-billion dollar effect – older skin is more at risk of injury, less able to sense touch, heat and cold, slower to heal and more prone to cellulitis and other skin infections.

Aging is a complex and gradual process characterized by a reduction in function and reproducibility along with an increase in the incidence of degenerative diseases. Skin aging has been reported to be associated with the presence and accumulation of senescent cells. “A number of diseases that increase in older people may have a unifying underlying mechanism having to do with senescence,” says Ruth Montgomery, PhD, professor of medicine and epidemiology (microbial diseases) at Yale School of Medicine [2].

Senescent cells are those that have lost their proliferative capacity, are resistant to apoptosis, and secrete factors that can cause tissue deterioration and inflammation [3]. These factors are termed senescence-associated secretory phenotype (SASP) and can lead to extracellular matrix (ECM) deposition, impact epidermal stem cell renewal and worsen melanin synthesis.

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