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In this episode of the Longevity Optimization Podcast, Dr. DeGray discusses groundbreaking research in aging and longevity, focusing on combination therapies, the hallmarks of aging, and the potential of stem cell and gene therapies. He emphasizes the importance of rejuvenation over merely slowing aging and explores the role of the immune system in health. The conversation also touches on biological age testing, lifestyle factors, and the future of gene therapy in enhancing longevity.

Aubrey de Grey is a British biomedical gerontologist and the founder of the SENS Research Foundation. He is a leading advocate for regenerative medicine, focusing on reversing the effects of aging by repairing cellular damage. Known for his bold vision of life extension, de Grey believes that with advanced therapies, humans could significantly extend their lifespan. He is the co-author of Ending Aging, and his work continues to shape the future of longevity science.

Takeaways.

Combination therapies are crucial for understanding aging.

Newly published research from Colorado State University answers fundamental questions about cellular connectivity in the brain that could be useful in the development of treatments for neurological diseases like autism, epilepsy or schizophrenia.

Imagine a tiny, soft robot that could change the way medicine is delivered to targeted areas in the body.


A team of scientists at NTU has developed grain-sized soft robots that can be controlled using magnetic fields for targeted drug delivery, paving the way to possible improved therapies in future.

The new soft robot developed by engineers at NTU’s School of Mechanical and Aerospace Engineering (MAE) was reported in a paper published in the journal Advanced Materials.

Virtual worlds, ChatGPT, and AI seem to be all the rage in 2024, with all sorts of developments shaking up not just the technology space, but having wider implications for medicine, politics, and even the judicial system. Now, researchers from Swiss startup FinalSpark have combined a virtual world with tiny human mini brains and built a two-way con…

Researchers have identified a key mechanism in the development of Alzheimer’s disease involving the growth and pause of amyloid β fibrils.

A newly discovered antibody can lock these fibrils in their paused state, offering a potential new approach for treatment that targets these critical growth points.

Breakthrough in Alzheimer’s Research.

Nuclear fission—when the nucleus of an atom splits in two, releasing energy—may seem like a process that is fully understood. First discovered in 1939 and thoroughly studied ever since, fission is a constant factor in modern life, used in everything from nuclear medicine to power-generating nuclear reactors. However, it is a force of nature that still contains mysteries yet to be solved.

Researchers from the University of Washington, Seattle, or UW, and Los Alamos National Laboratory have used the Summit supercomputer at the Department of Energy’s Oak Ridge National Laboratory to answer one of fission’s biggest questions: What exactly happens during the nucleus’s “neck rupture” as it splits in two?

The resulting paper is published in the journal Physical Review Letters.

Researchers Takuma Nakamura, Kazuki Hashimoto, and Takuro Ideguchi of the Institute for Photon Science and Technology at the University of Tokyo have increased by 100-fold the measurement rate of Raman spectroscopy, a common technique for measuring the “vibrational fingerprint” of molecules in order to identify them.

As the measurement rate has been a major limiting factor, this improvement contributes to advancements in many fields that rely on identifying molecules and cells, such as biomedical diagnostics and material analytics. The findings were published in the journal Ultrafast Science.

Identifying various types of molecules and cells is a crucial step in both basic and applied science. Raman spectroscopy is a widely used measurement technique for this purpose. When a is projected onto molecules, the light interacts with the vibrations and rotations of molecular bonds, shifting the frequency of the scattering light. The scattering spectra thus measured is a molecule’s unique “vibrational fingerprint.”

By Chuck Brooks & Dr. Thomas A. Cellucci, MBA


Co-written by Chuck Brooks and Dr. Thomas A. Cellucci, MBA

Verticals that will be most impacted by innovative developments in technology and science are the disciplines of medicine, biotechnology, and health. Those industry verticals will see a profound growth of technological innovation in the near future.

Twenty years ago, Craig Venter and Daniel Cohen remarked, “If the 20th century was the century of physics, the 21st century will be the century of biology.” Since then, there have been some amazing advances in the fields of biotechnology and bioscience, with the promise of even more astounding breakthroughs to come. Over the past decade, we have seen significant strides in artificial intelligence, with radical long-term implications for every human endeavor. And now the convergence of the fields of physics, biology, and AI promises a far greater impact on humanity than any one of these fields alone. Even though a path to successfully integrating these fields exists, it is neither easy nor clear cut—but if done correctly, will revolutionize medicine and human health.