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Moderna is prepping for the global launch of its potential coronavirus vaccine, already taking in $1.1 billion in deposits from governments awaiting the potentially lifesaving drug, the biotech firm said Thursday in its third-quarter earnings report.

The Cambridge, Massachusetts-based company said it was in ongoing talks with the World Health Organization-backed COVAX initiative on a tiered pricing proposal for its potential vaccine, which it’s tentatively calling mRNA-1273. It already has supply agreements in North America, the Middle East and in other regions of the world.

“We are actively preparing for the launch of mRNA-1273 and we have signed a number of supply agreements with governments around the world,” Moderna CEO Stephane Bancel said in a press release. “Moderna is committed to the highest data quality standards and rigorous scientific research as we continue to work with regulators to advance mRNA-1273.”

Many of the fundamental principles in biology and essentially all pathways regulating development were identified in so-called genetics screens. Originally pioneered in the fruit fly Drosophila and the nematode C. elegans, genetic screens involve inactivation of many genes one by one. By analyzing the consequences of gene loss, scientists can draw conclusions about its function. This way, for example, all genes required for formation of a brain can be identified.

Genetic screens can routinely be carried out in flies and worms. In humans, a wealth of knowledge exists about genetic disorders and the consequences of disease-relevant mutations, but their systematic analysis was impossible. Now, the Knoblich lab at IMBA has developed a groundbreaking technique allowing hundreds of genes to be analyzed in parallel in human tissue. They named the new technology CRISPR-LICHT and published their findings in the journal Science.

By using cerebral organoids, a 3D cell culture model for the human brain developed in Jürgen Knoblich’s group at IMBA, hundreds of mutations can now be analyzed for their role in the human brain using CRISPR-LICHT.

More than a century ago, in 1910, President William Howard Taft made what then seemed a bold but reasonable prediction: “Within five years,” he said.

BOSTON (AP) — Federal agencies warned that cybercriminals are unleashing a wave of data-scrambling extortion attempts against the U.S. healthcare system designed to lock up hospital information systems, which could hurt patient care just as nationwide cases of COVID-19 are spiking.

In a joint alert Wednesday, the FBI and two federal agencies warned that they had “credible information of an increased and imminent cybercrime threat to U.S. hospitals and healthcare providers.” The alert said malicious groups are targeting the sector with attacks that produce “data theft and disruption of healthcare services.”

The cyberattacks involve ransomware, which scrambles data into gibberish that can only be unlocked with software keys provided once targets pay up. Independent security experts say it has already hobbled at least five U.S. hospitals this week, and could potentially impact hundreds more.

As cells bump into each other, forces cause them to move and shake, or even sometimes rupture.

“Cells are constantly generating forces and responding to them. They are being pulled on by their environment,” said Jonathan Winkelman, a postdoctoral researcher at the University of Chicago. Winkelman works in the lab of Margaret Gardel, professor in the Department of Physics and the Pritzker School of Molecular Engineering.

Unlike a rubber band that breaks when you stretch it too much, an overstretched cell initiates a response to repair itself. This phenomenon has been observed using microscopy, but the question of how the repair and adaptation process initiates inside the cells has remained unanswered until now.

Article. I guess having implants directly on the brain isn’t the only way to have a brain to machine interface. The scientists involved in the study found an alternative by picking up signals through the blood vessels.

It’s not as information packed as a direct brain connection, but it’s not as invasive.

I think it would be a good alternative or even complementary to direct brain implants. Interesting. 😃

Continue reading “A New Way to Plug a Human Brain Into a Computer: via Veins” »

While our circadian body clock dictates our preferred rhythm of sleep or wakefulness, a relatively new concept—the epigenetic clock—could inform us about how swiftly we age, and how prone we are to diseases of old age.

People age at different rates, with some individuals developing both characteristics and diseases related to aging earlier in life than others. Understanding more about this so-called ‘biological age’ could help us learn more about how we can prevent diseases associated with age, such as dementia. Epigenetic markers control the extent to which genes are switched on and off across the different cell-types and tissues that make up a human body. Unlike our genetic code, these epigenetic marks change over time, and these changes can be used to accurately predict biological age from a DNA sample.

Now, scientists at the University of Exeter have developed a new epigenetic clock specifically for the human brain. As a result of using human brain tissue samples, the new clock is far more accurate than previous versions, that were based on blood samples or other tissues. The researchers hope that their new clock, published in Brain and funded by Alzheimer’s Society, will provide insight into how accelerated aging in the brain might be associated with brain diseases such as Alzheimer’s disease and other forms of dementia.

A team headed by Prof. Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology), in collaboration with Dr. Emanuele Berardi and Dr. Min Shang, revealed a new metabolic dialogue between inflammatory cells and muscle stem cells. The researchers show that strengthening this metabolic crosstalk with an inhibitor of the enzyme GLUD1 fosters the release of glutamine, and improves muscle regeneration and physical performance in experimental models of muscle degeneration such as trauma, ischemia, and aging. Besides its translational potential, this work also provides key advances in several fields of research including muscle biology, immunometabolism, and stem cell biology.

The role of glutamine

Skeletal muscle is instrumental to move our body, but it is also a large reservoir of amino acids stored as proteins and it influences energy and protein metabolism throughout the human body. The role of the amino acid glutamine has been considered central for muscle metabolism because of its abundance. However, its precise role after trauma or during chronic muscle degenerative conditions were largely neglected.

The complex network of interconnected cellular signals produced in response to changes in the human body offers a vast amount of interesting and valuable insight that could inform the development of more effective medical treatments. In peripheral immune cells, these signals can be observed and quantified using a number of tools, including cell profiling techniques.

Single-cell profiling techniques such as polychromatic flow and mass cytometry have improved significantly over the past few years and they could now theoretically be used to obtain detailed immune profiles of patients presenting a number of symptoms. Nonetheless, the limited sample sizes of past studies and the high dimensionality of the patient data collected so far increase the chances of false-positive discoveries, which in turn lead to unreliable immune profiles.

Conducting studies on larger groups of patients could improve the effectiveness of these cell-profiling techniques, allowing medical researchers to gain a better understanding of the patterns associated with medical conditions. Gathering data from many patients, however, can be both expensive and time consuming.