Lifeboat Foundation

Using CRISPR technology, researchers are tracking the lineage of individual cancer cells as they proliferate and metastasize in real-time.

When cancer is confined to one spot in the body, doctors can often treat it with surgery or other therapies. Much of the mortality associated with cancer, however, is due to its tendency to metastasize, sending out seeds of itself that may take root throughout the body. The exact moment of metastasis is fleeting, lost in the millions of divisions that take place in a tumor. “These events are typically impossible to monitor in real time,” says Jonathan Weissman, MIT professor of biology and Whitehead Institute for Biomedical Research member.

Now, researchers led by Weissman, who is also an investigator with the Howard Hughes Medical Institute, have turned a CRISPR tool into a way to do just that. In a paper published on January 212021, in Science, Weissman’s lab, in collaboration with Nir Yosef, a computer scientist at the University of California at Berkeley, and Trever Bivona, a cancer biologist at the University of California at San Francisco, treats cancer cells the way evolutionary biologists might look at species, mapping out an intricately detailed family tree. By examining the branches, they can track the cell’s lineage to find when a single tumor cell went rogue, spreading its progeny to the rest of the body.

Researchers at Tokyo Medical and Dental University (TMDU) in Japan show that melatonin and its metabolites promote the formation of long-term memories in mice and protect against cognitive decline.

Researchers at Tokyo Medical and Dental University (TMDU) showed that melatonin’s metabolite AMK can enhance the formation of long-term memories in mice. Memory of objects were tested after treatment with melatonin or two of its metabolites. Older mice that normally performed poorly on the memory task showed improvements as dosage increased. The metabolite AMK was found to be the most important as melatonin failed to improve memory if it was blocked from metabolizing into AMK.

Walk down the supplement aisle in your local drugstore and you’ll find fish oil, ginkgo, vitamin E, and ginseng, all touted as memory boosters that can help you avoid cognitive decline. You’ll also find melatonin, which is sold primarily in the United States as a sleep supplement. It now looks like melatonin marketers might have to do a rethink. In a new study, researchers led by Atsuhiko Hattori at Tokyo Medical and Dental University (TMDU) in Japan have shown that melatonin and two of its metabolites help memories stick around in the brain and can shield mice, and potentially people, from cognitive decline.

German drone technology startup Wingcopter has raised a $22 million Series A – its first significant venture capital raise after mostly bootstrapping. The company, which focuses on drone delivery, has come a long way since its founding in 2017, having developed, built and flown its Wingcopter 178 heavy-lift cargo delivery drone using its proprietary and patented tilt-rotor propellant mechanism, which combines all the benefits of vertical take-off and landing with the advantages of fixed-wing aircraft for longer-distance horizontal flight.

This new Series A round was led by Silicon Valley VC Xplorer Capital, as well as German growth fund Futury Regio Growth. Wingcopter CEO and founder Tom Plümmer explained in an interview that the addition of an SV-based investor is particularly important to the startup, since it’s in the process of preparing its entry into the U.S., with plans for an American facility, both for flight testing to satisfy FAA requirements for operational certification, as well as eventually for U.S.-based drone production.

Wingcopter has already been operating commercially in a few different markets globally, including in Vanuatu in partnership with Unicef for vaccine delivery to remote areas, in Tanzania for two-way medical supply delivery and in Ireland where it completed the world’s first delivery of insulin by drone beyond visual line of sight (BVLOS), the industry’s technical term for when a drone flies beyond the visual range of a human operator who has the ability to take control in case of emergencies.

The makers of Sophia the robot are set to mass produce thousands of humanoid machines starting this year.

Hong-Kong based company Hanson Robotics will roll out four new models in the first half of 2021 after its humanoid robot Sophia went viral in 2016.

Continue reading “Thousands of humanoid robots set to be produced this year” »

Factory worker jobs could be further at risk as the pandemic accelerates plans.

Scientists from UNSW Sydney have developed a ceramic-based ink that may allow surgeons in the future to 3D-print bone parts complete with living cells that could be used to repair damaged bone tissue.

Using a 3D-printer that deploys a special ink made up of calcium phosphate, the scientists developed a new technique, known as ceramic omnidirectional bioprinting in cell-suspensions (COBICS), enabling them to print bone-like structures that harden in a matter of minutes when placed in water.

While the idea of 3D-printing bone-mimicking structures is not new, this is the first time such material can be created at room temperature—complete with living cells—and without harsh chemicals or radiation, says Dr. Iman Roohani from UNSW’s School of Chemistry.

Specifically, the researchers looked at lupus, which attacks the body’s own immune system, along with antiphospholipid syndrome (often associated with lupus), which causes blood clots. Both the diseases cause widespread inflammation and ravage organs overtime. In mice with either of the disease, 6-gingerol stopped the neutrophil extracellular trap release caused by the diseases’ production of autoantibodies.

“Neutrophil extracellular traps, or NETs, come from white blood cells called neutrophils,” explained lead author Ramadan Ali, Ph.D in a press release. “These sticky spider-web like structures are formed when autoantibodies interact with receptors on the neutrophil’s surface.”

The webs, according to Ali, play a fundamental role in the pathogenesis of lupus and antiphospholipid syndrome in which they set off autoantibody formation and contribute to clots in blood vessels and other damage.

Here’s a riddle: What do the Moon, nuclear weapons, clean energy of the future, terrorism, and lung disease all have in common?

The answer is helium-3, a gas that’s extremely rare on Earth but 100 million times more abundant on the Moon.

The capability to show anatomic details of the lungs and airways, and the ability to display functional imaging as a patient breathes, makes helium-3 MRI far better than the standard method of testing lung function. Called spirometry, this method tells physicians how the lungs function overall, but does not home in on particular areas that may be causing a problem. Plus, spirometry requires patients to follow instructions and hold their breath, so it is not great for testing young children with pulmonary disease.

Continue reading “Shoot for the Moon: Its Surface Contains a Pot of Gold” »

“Social robots like me can take care of the sick or elderly,” Sophia says as she conducts a tour of her lab in Hong Kong. “I can help communicate, give therapy and provide social stimulation, even in difficult situations.”