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Category: biotech/medical – Page 136

Computational tool ranks compounds to improve cancer immunotherapy effectiveness

A study published in Cell Reports Medicine reports a scalable, data-driven computational framework for designing combinatorial immunotherapies, offering hope for patients with poor responses to current immunotherapies.

Immunotherapy, particularly immune checkpoint blockade (ICB), has revolutionized . Widespread resistance to ICB is a major challenge in clinical practice.

To enhance treatment efficacy and overcome resistance, combining ICB therapy with chemotherapy or targeted therapy has become an important research direction. However, candidate combinations rely on empirical selection from existing drugs, and it is difficult to discover new candidates.

This bedtime snack swap could rewire your gut and help prevent diabetes

Eating pistachios every night for 12 weeks altered bacteria in the gut, according to new study. A new study reveals that swapping a typical nighttime carbohydrate snack for pistachios may beneficially alter gut bacteria in people with prediabetes. Conducted by Penn State researchers, the 12-week clinical trial found that pistachio consumption increased beneficial gut microbes like Roseburia and reduced harmful ones such as Blautia hydrogenotrophica. These microbiome changes could potentially support metabolic health and slow the progression to Type 2 diabetes. While more research is needed to confirm health outcomes, this study positions pistachios as a promising late-night snack with microbiome-boosting potential.

Prediabetes affects a third of people in the United States and most of them will develop Type 2 diabetes, yet effective dietary intervention strategies remain limited. Pistachios have shown promise in improving markers of diet quality, yet little is known about how they influence the gut microbiome — a key player in glucose regulation and inflammation.

A new study led by Kristina Petersen, associate professor of nutritional sciences at Penn State, determined that nighttime pistachio consumption affects gut bacteria in adults with prediabetes. Though the potential therapeutic implications of the findings remain unclear, according to Petersen, they may prove significant for people who are working to improve their metabolic health.

Scientists find ‘speed limit’ for innovation networks to prevent system collapse

Research shows that while connections between innovations speed discovery, they also sharply increase the risk of total system collapse—with the sweet spot for sustainable innovation proving surprisingly narrow.

Innovation is a central currency of global power. Whether in the race for leadership in , the development of clean energy technologies, or the search for medical breakthroughs, major players like China, the United States, and the European Union are investing billions in research and development to secure the next technological leap—and with it, economic and strategic advantage.

Yet, as a new study from the Complexity Science Hub (CSH), published in Physical Review Research, indicates, long-term innovation is only sustainable under specific structural conditions. First, the study finds that innovation can only endure over time if it is balanced with “exnovation”—the loss or forgetting of older possibilities.

Anti-neuroinflammatory natural products from isopod-related fungus now accessible via chemical synthesis

“Herpotrichone” is a natural substance that has been evaluated highly for its excellent ability to suppress inflammation in the brain and protect nerve cells, displaying significant potential to be developed as a therapeutic agent for neurodegenerative brain diseases such as Alzheimer’s disease and Parkinson’s disease. This substance could only be obtained in minute quantities from fungi that are symbiotic with isopods. However, KAIST researchers have succeeded in chemically synthesizing this rare natural product, thereby presenting the possibility for the development of next-generation drugs for neurodegenerative diseases.

A research team led by Professor Sunkyu Han of the Department of Chemistry successfully synthesized the natural anti-neuroinflammatory substances ‘herpotrichones A, B, and C’ for the first time. The paper is published in the Journal of the American Chemical Society.

Herpotrichone natural products are substances obtainable only in minute quantities from Herpotrichia sp. SF09, a symbiotic pill bug fungus, and possesses a unique 6÷6÷6÷6÷3 pentacyclic framework consisting of five fused rings (four six-membered and one three-membered ring).

Machine learning model helps scientists understand deadly cone snail toxins

Marine cone snails are host to a family of dangerous neurotoxins. Very little is known about how those toxins interact with the human body, making this an area of interest for medical drug research and an area of concern in national security spaces. For the first time, a team at Los Alamos National Laboratory has successfully trained a machine learning model that predicts how alpha conotoxins bind to specific human receptor subtypes, which could help researchers develop lifesaving anti-toxins.

“Because of the diversity and complexity of natural conotoxins, it is estimated that only 2% of them have been sequenced,” said Gnana Gnanakaran, theoretical biologist at Los Alamos. “No antidotes exist for conotoxins, but by using machine learning to predict conotoxin binding, we now have the ability to develop tools to understand and respond to these threats.”

The deadly secretions issued by any one of the more than 800 cone snail species represent a conglomeration of more than 1 million natural conotoxins. The research team concentrated their machine learning work on alpha conotoxins, a particularly prevalent and deadly conotoxin family.

Is the Multiverse Real? New Quantum Tech Might Finally Tell Us

Imagine a gamma ray laser that safely eliminates cancer cells while leaving healthy tissue unharmed. A University of Colorado Denver engineer is close to providing researchers with a powerful new tool that could bring science fiction concepts closer to reality. Consider the potential of a gamm

Vagus nerve stimulation paired with meditation increases self-compassion and mindfulness benefits

Stimulating the vagus nerve with a device attached to the outer ear can help make compassion meditation training more effective at boosting people’s capacity for self-kindness and mindfulness, finds a new study led by University College London (UCL) researchers.

The study, published in Psychological Medicine, adds to evidence of the potential benefits of stimulating this key nerve that connects the brain with major organs in the chest and abdomen.

The plays a crucial role in the “rest-and-digest” (parasympathetic) system, counteracting the “fight-or-flight” (sympathetic) , and allows the brain to communicate with all major organs in the body. By transmitting signals from the body up to the brain, the vagus nerve can also regulate a range of psychological processes, including some involved in social interactions and emotional control.

Autologous Hematopoietic Stem Cell Transplantation for Paraneoplastic Cerebellar Degeneration

Background and ObjectivesThe aim of this study was to describe 2 patients with paraneoplastic cerebellar degeneration (PCD) treated with autologous hematopoietic stem cell transplantation (AHSCT).MethodsOff-label AHSCT was performed at Hospital Clinic…

Scientists just cracked the code to editing entire chromosomes flawlessly

A group of Chinese scientists has created powerful new tools that allow them to edit large chunks of DNA with incredible accuracy—and without leaving any trace. Using a mix of advanced protein design, AI, and clever genetic tweaks, they’ve overcome major limitations in older gene editing methods. These tools can flip, remove, or insert massive pieces of genetic code in both plants and animals. To prove it works, they engineered rice that’s resistant to herbicides by flipping a huge section of its DNA—something that was nearly impossible before.

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