Physicists in Australia and the United Kingdom have found a way to reshape quantum uncertainty, offering a new method that bypasses the limits set by the well-known Heisenberg uncertainty principle. Their discovery could lay the groundwork for next-generation sensors with extraordinary precision, with potential uses in navigation, medical imaging, and astronomy.
The Heisenberg uncertainty principle, first introduced in 1927, states that it is impossible to know certain pairs of properties, such as a particle’s position and momentum, with unlimited accuracy at the same time. In practice, this means that increasing precision in one property inevitably reduces certainty in the other.
In a study published in Science Advances, researchers led by Dr. Tingrei Tan of the University of Sydney Nano Institute and School of Physics demonstrated how to design an alternative trade-off, one that allows position and momentum to be measured simultaneously with exceptional accuracy.
From 2013 to 2023, rates of cognitive disability nearly doubled among U.S. adults under 40.
Cognitive disability includes self-reported serious difficulty concentrating, remembering, or making decisions.
Rates are highest among people with chronic diseases or lower household incomes.
Background and Objectives.
A Cornell-led study has revealed how a deadly form of pancreatic cancer enters the bloodstream, solving a long-standing mystery of how the disease spreads and identifying a promising target for therapy.
Pancreatic ductal adenocarcinoma is among the most lethal cancers, with fewer than 10% of patients surviving five years after diagnosis. Its microenvironment is a dense, fibrotic tissue that acts like armor around the tumor. This barrier makes drug delivery difficult and should, in theory, prevent the tumor from spreading. Yet the cancer metastasizes with striking efficiency—a paradox that has puzzled scientists.
New research published in the journal Molecular Cancer reveals that a biological receptor called ALK7 is responsible, by activating two interconnected pathways that work in tandem. One makes cancer cells more mobile through a process called epithelial-mesenchymal transition, and the other produces enzymes that physically break down the blood vessel walls.
CAR T cells are patient-derived, genetically engineered immune cells. They are “living drugs” and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a “chimeric antigen receptor” (CAR) enables them to specifically recognize and attack cancer cells.
CAR T cell therapy has demonstrated its potential by curing patients with otherwise untreatable blood cancers. But it still fails for most patients, often due to T cell intrinsic dysfunction. To address their current limitations and to make CAR T cells intrinsically stronger, scientists at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna have developed a new method for systematic discovery of genetic boosters of CAR T cell function.
The new study, published in Nature, introduces CELLFIE, a CAR T cell engineering and high-content CRISPR screening platform, enabling researchers to systematically modify CAR T cells and evaluate their therapeutic potential.
Korean researchers have uncovered compelling evidence that oral bacteria, once colonized in the gut, can affect neurons in the brain and potentially trigger Parkinson’s disease.
The joint research team, led by Professor Ara Koh and doctoral candidate Hyunji Park of POSTECH’s Department of Life Sciences, together with Professor Yunjong Lee and doctoral candidate Jiwon Cheon of Sungkyunkwan University School of Medicine, collaborated with Professor Han-Joon Kim of Seoul National University College of Medicine.
They have identified the mechanism by which metabolites produced by oral bacteria in the gut may trigger the development of Parkinson’s disease. The findings were published online in Nature Communications.
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Everybody develops presbyopia as they age—a difficulty in focusing on near objects and text—and often must resort to reading glasses. However, the solution might be as simple as using special eye drops two or three times a day.
A retrospective study of 766 patients presented at the 43rd Congress of the European Society of Cataract and Refractive Surgeons (ESCRS) has found that the majority could read an extra two, three or more lines on the eye chart used for testing near visual acuity (the Jaeger chart) after using specially formulated eye drops. This improvement was sustained for up to two years.
Dr. Giovanna Benozzi, director of the Center for Advanced Research for Presbyopia, in Buenos Aires, Argentina, said, We conducted this research due to the significant unmet medical need in presbyopia management. Current solutions such as reading glasses or surgical interventions have limitations, including inconvenience, social discomfort, and potential risks or complications.
Scientists have uncovered how a key type of immune cell adapts its behavior depending on the type of infection, paving the way for better vaccines and advancing research into immune-related diseases.
In their study published in Nature Immunology, a WEHI-led research team has revealed how T follicular helper (Tfh) cells tailor their instructions to the immune system depending on the pathogen they encounter.
The findings shed light on the molecular “instruction manual” that guides antibody production and long-term immunity, offering new tools to improve vaccine design and develop targeted therapies for immune-related conditions and other major health challenges, including cancer.