University of North Carolina Lineberger Comprehensive Cancer Center researchers have developed a “two-in-one” molecule that can simultaneously turn off two notoriously difficult-to-target cancer-related genes, KRAS and MYC, as well as directly deliver drugs to tumors that express these genes. This advance holds special promise for treating cancers that have been historically challenging to treat.
The new technology incorporates novel compositions of inverted RNAi molecules that have shown a marked ability to co-silence mutated KRAS and over-expressed MYC. RNA interference (RNAi) is a cellular process that uses small interfering RNAs (siRNAs) to selectively turn off, or silence, mutated genes. The co-silencing resulted in up to a 40-fold improvement in inhibition of cancer cell viability compared to the use of individual siRNAs.
The laboratory findings were published in the Journal of Clinical Investigation on July 31.
Researchers from China and us create shape shifting robot:
In a scene straight out of science fiction, researchers from China and the U.S. have developed a shape-shifting robot made from magnetically responsive liquid metal that can melt, flow, escape confinement, and reassemble itself—all on command.
Inspired by sea cucumbers and powered by gallium, a metal with a melting point just above room temperature, the robot can switch between solid and liquid states using magnetic fields. During tests, it was able to melt, escape from a prison-like cage, and then re-solidify into its original form—without losing function.
Unlike traditional rigid robots, this breakthrough allows machines to:
* Navigate tight or complex spaces * Heal themselves or split apart to avoid damage * Perform surgical tasks inside the human body without invasive procedures * Transition between tool-like solidity and liquid flexibility.
The magnetic fields not only induce the phase change but also control movement, making the robot swim, climb walls, and even jump. Researchers envision future uses in minimally invasive medicine, like removing foreign objects from internal organs, or in electronic assembly, where the robot could flow into hard-to-reach places and form circuits.
This review examines the latest advancements in compositional and quantitative cartilage MRI techniques, addressing both their potential and challenges. The integration of these advancements promises to improve disease detection, treatment monitoring, and overall patient care. We want to highlight the pivotal task of translating these techniques into widespread clinical use, the transition of cartilage MRI from technical validation to clinical application, emphasizing its critical role in identifying early signs of degenerative and inflammatory joint diseases. Recognizing these changes early may enable informed treatment decisions, thereby facilitating personalized medicine approaches. The evolving landscape of cartilage MRI underscores its increasing importance in clinical practice, offering valuable insights for patient management and therapeutic interventions.
Research from an international team finds that the human gut is a site of rapid change, with recent and important deviations from other mammals, including our closest living relative, the chimpanzee.
Led by Gray Camp, Ph.D., of Roche Innovation Center in Basel, Switzerland; Jason Spence, Ph.D., of the University of Michigan and Craig Lowe, Ph.D., of Duke University, the team used stem cells to create human, chimp and mouse intestinal organoids—tiny models of the intestine that offer an unprecedented glimpse into the development of the small intestine.
The work was published in the journal Science.
Concordance was high between imputed and sequenced APOE genotypes. Moreover, the researchers replicated known GWAS associations with diet-related biomarkers.
The authors also noted several limitations to provide context for future research. These include that the study population was predominantly of European ancestry, which may limit the generalizability of findings, and that the specific participant criteria (e.g., overweight, family history of dementia) mean the resource is not representative of the general population. They also advise that potential batch effects from specimen type and study site should be accounted for in future analyses.
This genetic resource enables analyses of genetic contributions to variability in cognitive responses to the MIND diet, supporting integrative analysis with other data types to delineate underlying biological mechanisms. The data will be made available to other researchers via The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS).
Researchers have developed a simple yet highly effective method for delivering mRNA to target cells, opening up new possibilities for future non-vaccine mRNA medicines for a broad range of diseases.
The Monash University study, published in Nature Nanotechnology, is a significant development in how mRNA is precisely delivered to cells to maximize efficacy and minimize off-target effects—vital components for future mRNA medicines as they continue to evolve.
Led by the Monash Institute of Pharmaceutical Scientists (MIPS), the interdisciplinary team of researchers used advanced technologies coupled with preclinical studies to produce a highly versatile method that captures and attaches antibodies to the surface of mRNA-loaded lipid nanoparticles while the antibodies are in their optimal orientation, thus enhancing the mRNA’s effectiveness and reducing side effects by making sure it only reaches its target destination.
Lysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.
NIA, NINDS: UNTANGLING THE VIRAL LINK TO NEURODEGENERATION
Scientists have long sought to understand the connection between viral infections and brain health. Can common viruses, which can reside unnoticed within our bodies, contribute to the development of neurodegenerative diseases such as Alzheimer’s and other forms of dementia? A study published in Science Advances led by researchers at the NIA tapped into data from thousands of human subjects offers compelling new insights into this enigmatic area of research.
The investigation examined the neurocognitive and plasma proteomic profiles of older adults in a community-based cohort from the Baltimore Longitudinal Study of Aging. Researchers focused on their antibody responses to four common coronaviruses and six herpesviruses with hopes of uncovering the molecular pathways linking the immune response to these viruses with brain aging and dementia risk.
