Lifeboat Foundation

SARS-CoV-2 originated in animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here we report a large-scale study to assess SARS-CoV-2 infection in 817 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.4% of dogs and 3.9% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.

One Sentence Summary SARS-CoV-2 antibodies in pets from Italy.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late December 2019 in Wuhan, Hubei province, China , possibly as a spillover from bats to humans , and rapidly spread worldwide becoming a pandemic. Although the virus is believed to spread almost exclusively by human-to-human transmission, there are concerns that some animal species may contribute to the ongoing SARS-CoV-2 pandemic epidemiology. To date, sporadic cases of SARS-CoV-2 infection have been reported in dogs and cats. These include detection of SARS-CoV-2 RNA in respiratory and/or fecal specimens of dogs and cats with or without clinical signs (5−7), as well as of specific antibodies in sera from pets from coronavirus disease 2019 (COVID-19) affected areas (7,8).

More durable prosthetics and medical devices for patients and stronger parts for airplanes and automobiles are just some of the products that could be created through a new 3D printing technology invented by a UMass Lowell researcher.

Substances such as plastics, metals and wax are used in 3D printers to make products and parts for larger items, as the practice has disrupted the prototyping and manufacturing fields. Products created through the 3D printing of plastics include everything from toys to drones. While the global market for 3D plastics printers is estimated at $4 billion and growing, challenges remain in ensuring the printers create objects that are produced quickly, retain their strength and accurately reflect the shape desired, according to UMass Lowell’s David Kazmer, a plastics engineering professor who led the research project.

Called injection printing, the technology Kazmer pioneered is featured in the academic journal Additive Manufacturing posted online last week.

The Stanford team worked with researchers at the Department of Energy’s Lawrence Berkeley National Laboratory to develop a technique called prophylactic antiviral CRISPR in human cells, or PAC-MAN. The technology disables viruses by scrambling their genetic code. The researchers developed a new way to deliver the technology into lung cells, they reported in the journal Cell.

Stanford bioengineers teamed up with researchers at the Lawrence Berkeley National Laboratory to develop a CRISPR system that neutralizes SARS-CoV-2 by scrambling the virus’s genetic code. They believe the technology could prove useful for combating several types of viruses, including influenza.

I posted about this a while back, as a treatment. I’m glad people are catching up.

Some doctors are now trying to deliver 100% oxygen to COVID patients in decompression chambers long used to treat divers with the bends.

As a New York University medical researcher who works once a week in an emergency room, Dr. David Lee had the luxury of time to think like a scientist while also treating coronavirus patients whose lungs kept giving out. In every case, he saw the same thing: Their blood was starved of oxygen.

Continue reading “Doctors try pressurized oxygen chambers in COVID fight” »

Summary: Activating p38gamma, a naturally protective enzyme in the brain, may help to prevent the development of Alzheimer’s disease symptoms. Researchers showed the naturally protective effects of p38gamma could be harnessed to improve memory in the later stages of Alzheimer’s disease.

Source: Macquarie University

Continue reading “New Hope as Dementia Therapy Reverses Memory Loss” »

The agreement with Sanofi and GlaxoSmithKelin is the government’s second in less than two weeks for 100 million doses of vaccine.

The first-of-its-kind, randomized, placebo-controlled, phase 1/2a trial will assess patients hospitalized at Florida and South Dakota institutions.

Researchers announce the first patient has been dosed in a trial testing remestemcel-L, a stem cell therapy, in severe COVID-19 patients on ventilators.

Testing of an experimental COVID-19 stem cell therapy has begun in the US. The therapy has been developed to treat hospitalised COVID-19 patients with moderate to severe acute respiratory distress syndrome (ARDS) who are on ventilators. A total of 300 are expected to be recruited into the randomised, placebo-controlled trial.

ENCODE Project’s third phase offers new insights into the organization and regulation of our genes and genome.

The Encyclopedia of DNA Elements (ENCODE) Project is a worldwide effort to understand how the human genome functions. With the completion of its latest phase, the ENCODE Project has added millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes are turned on, and a new registry that assigns a portion of these DNA switches to useful biological categories. The project also offers new visualization tools to assist in the use of ENCODE’s large datasets.

The project’s latest results were published in Nature, accompanied by 13 additional in-depth studies published in other major journals. ENCODE is funded by the National Human Genome Research Institute, part of the National Institutes of Health.