Lifeboat Foundation

I always enjoy the perspective of David Wood, and in this session of the London Futurists there is a panel discussion about genetic engineering in the future.

Our DNA is becoming as readable, writable, and hackable as our information technology. The resulting genetic revolution is poised to transform our healthcare, our choices for the characteristics of the next generation, and our evolution as a species. The future could bring breathtaking advances in human well-being, but it could also descend into a dangerous genetic arms race.

Continue reading “Hacking Darwin: Genetic Engineering and the Future of Humanity” »

Maryland reported its highest number of new COVID-19 cases on Tuesday—just four days after the state began easing public health restrictions aimed at thwarting the spread of disease.

Though state officials note that an increase in testing and a backlog of test results may partly explain the spike, the case counts overall suggest that disease transmission has not declined in the lead-up to re-opening—and transmission could very easily increase as residents begin venturing into public spaces more frequently.

Maryland’s outcome may hold lessons for other states attempting their own reopening. As of today, May 20, all 50 states have begun easing restrictions at some level, according to The Washington Post.

Before there were animals, bacteria or even DNA on Earth, self-replicating molecules were slowly evolving their way from simple matter to life beneath a constant shower of energetic particles from space.

In a new paper, a Stanford professor and a former post-doctoral scholar speculate that this interaction between ancient proto-organisms and cosmic rays may be responsible for a crucial structural preference, called chirality, in biological molecules. If their idea is correct, it suggests that all life throughout the universe could share the same chiral preference.

Chirality, also known as handedness, is the existence of mirror-image versions of molecules. Like the left and right hand, two chiral forms of a single molecule reflect each other in shape but don’t line up if stacked. In every major biomolecule—amino acids, DNA, RNA—life only uses one form of molecular handedness. If the mirror version of a molecule is substituted for the regular version within a biological system, the system will often malfunction or stop functioning entirely. In the case of DNA, a single wrong handed sugar would disrupt the stable helical structure of the molecule.

From testing drugs to developing vaccines, the close study of the immune system is key to improving real-world health outcomes. T-cells are integral to this research, as these white blood cells help tailor the body’s immune response to specific pathogens.

With lattice light-sheet microscopy (LLSM), scientists have been able to closely examine individual cells, such as T-cells, in 4D. But with limited data points, there wasn’t an effective way to analyze the LLSM data.

A new paper by researchers from the Pritzker School of Molecular Engineering (PME) at the University of Chicago, published May 20 in the journal Cell Systems, introduces a solution—a pipeline for lattice light-sheet microscopy multi-dimensional analyses (LaMDA).

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

Malaria is a major infectious disease, caused by a parasite with a complicated life cycle in humans and mosquitoes. The first stage in humans takes place in the liver, the second in the blood. Since the liver phase does not cause any symptoms of disease, but the blood phase does, the purpose of the vaccine is to stop the parasite in the liver.

Temporary tattoo electrodes are the most recent development in the field of cutaneous sensors. They have successfully demonstrated their performances in the monitoring of various electrophysiological signals on the skin. These epidermal electronic devices offer a conformal and imperceptible contact with the wearer while enabling good quality recordings over time. Evaluations of brain activity in clinical practice face multiple limitations, where such electrodes can provide realistic technological solutions and increase diagnostics efficiency. Here we present the performance of inkjet-printed conducting polymer tattoo electrodes in clinical electroencephalography and their compatibility with magnetoencephalography. The working mechanism of these dry sensors is investigated through the modeling of the skin/electrode impedance for better understanding of the biosignals transduction at this interface. Furthermore, a custom-made skin phantom platform demonstrates the feasibility of high-density recordings, which are essential in localizing neuropathological activities. These evaluations provide valuable input for the successful application of these ultrathin electronic tattoos sensors in multimodal brain monitoring and diagnosis.

More than 100,000 coronavirus cases have been reported to the World Health Organization in the last 24 hours, “the most in a single day since the outbreak began,” director-general Dr. Tedros Adhanom Ghebreyesus, said at a news conference Wednesday.

“We still have a long way to go in this pandemic,” he said. “In the last 24 hours, there have been 106,000 cases reported to WHO — the most in a single day since the outbreak began.”

Tedros added that almost “two-thirds of these cases were reported in just four countries,” although he did not specify where the cases had been recorded.

Circa 2019

Cerebral palsy is a condition that results from injuries or abnormalities of the brain, usually in the womb but occurring any time during 2 years after birth. It affects brain and nervous system functions such as thinking, seeing, hearing, learning and movement.

Continue reading “Stem Cell Therapy for Cerebral Palsy” »

After biomedical scientists demonstrated that they could make dangerous viruses like influenza even more dangerous, the National Institutes of Health (NIH) implemented a three-year moratorium on funding such research. But a couple of months ago, in December, the moratorium was lifted, and a tight set of rules were put in its place, such as a mandate for oversight panels.

The prospect of engineering a deadly pandemic virus in a laboratory suggests that only a fool would wish away government regulation entirely.

However, as a whole, regulation has done more harm than good in the arena of scientific innovation. The reason is that the sort of person who thinks like a bureaucratic regulator isn’t the sort of person who thinks like a scientist. The sad fact of the matter is that those most interested in the regulatory process tend to be motivated by politics and ideology rather than scientific inquiry and technological progress.