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Category: biotech/medical – Page 1,636
Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration
Circa 2018 immortality of the kidneys.
Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting their differentiation and angiogenic potential. Recent studies reported that specific abnormalities caused by the non-inherited disease are often retained in induced pluripotent stem cell (iPSC)-derived products obtained from patients. Thus, it is indispensable to first assess whether iPSCs derived from patients with CKD due to non-inherited disease (CKD-iPSCs) have the ability to generate kidneys.
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats
Circa 2021 First breakthrough in immortality of the eyes of rats using the inducing of pluripotent stem cells in the eye. Which will eventually lead to immortality of the human eye.
The retina is neural tissue located in the posterior part of the eye and is an extension of the central nervous system (CNS), which has limited regenerative potential once damaged1. Therefore, to maintain homeostasis of the retinal microenvironment and protect itself from harmful stimuli, the retina has a unique structure consisting of inner and outer blood-retinal barriers (BRBs)2,3,4. The outer BRB is mainly composed of retinal pigment epithelial (RPE) cells, which support photoreceptor cells, the primary neurons in the retina, and play a significant role in the pathogenesis of retinal degenerative disorders, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP)5,6,7,8,9. These disorders are commonly characterized by the irreversible loss of photoreceptor cells and RPE cells, and the only fundamental treatment for these retinal degenerative disorders is replacement of damaged or atrophied cells10,11,12. Thus, regenerative treatments, such as stem cell transplantation, are emerging as attractive options for targeting retinal degeneration that was previously considered untreatable13.
RP refers to a set of hereditary retinal degenerative disorders that initially involve photoreceptors and leads to subsequent RPE cell damage; it affects 1 in 4,000 individuals worldwide9. Due to its inherent nature, extensive genetic studies are ongoing, and more than 50 causal genes have been identified14. Among the causal genes, PDE6B is a gene that encodes rod cGMP-phosphodiesterase, which is a critical component of the biochemical light transduction pathway9. Although various molecular and genetic studies have identified the pathomechanisms of RP, attempts to restore vision in patients with RP have failed. To overcome this issue, preclinical stem cell-based studies involving transient dosing or permanent implantation of pluripotent stem cells are being conducted10,11,15,16.
Permanent implantation of retinal stem cells is a promising method and is highly expected to be a potential alternative treatment strategy for replacing damaged retinal cells13,16. Sharma et al.17 manufactured clinical-grade AMD patient stem cell-derived RPE cells using RPE patches of a biodegradable scaffold, and functionally validated the effects of their transplantation. This researchers provided a pipeline for the generation of clinical-grade induced pluripotent stem cell (iPSC)-derived RPE cells, and histologically and functionally validated the efficacy of transplantation, thereby significantly advancing the retinal stem cell transplantation field; however, a single RPE cell transplantation cannot rescue already compromised photoreceptor cells and can be only applied in early stages of retinal degenerative diseases, when there are sufficient functional photoreceptor cells.
Three Kids Are Thriving After Kidney Transplants With No Immunosuppressants
Our bodies can’t plug-and-play organs like replacement computer parts. The first rule of organ transplant is that the donor organs need to “match” with the host to avoid rejection. That is, the protein molecules that help the body discriminate between self and other need to be similar—a trait common (but not guaranteed) among members of the same family.
The key for getting an organ to “take” is reducing destructive immune attacks—the holy grail in transplantation. One idea is to genetically engineer the transplanted organ so that it immunologically “fits” better with the recipient. Another idea is to look beyond the organ itself to the source of rejection: haemopoietic stem cells, nestled inside the bone marrow, that produce blood and immune cells.
DISOT’s theory is simple but clever: swap out the recipient’s immune system with the donor’s, then transplant the organ. The recipient’s bone marrow is destroyed, but quickly repopulates with the donor’s stem cells. Once the new immune system takes over, the organ goes in.
In Its Greatest Biology Feat Yet, AI Unlocks the Complex Proteins Guarding Our DNA
Yet when faced with enormous protein complexes, AI faltered. Until now. In a mind-bending feat, a new algorithm deciphered the structure at the heart of inheritance—a massive complex of roughly 1,000 proteins that helps channel DNA instructions to the rest of the cell. The AI model is built on AlphaFold by DeepMind and RoseTTAfold from Dr. David Baker’s lab at the University of Washington, which were both released to the public to further experiment on.
Our genes are housed in a planet-like structure, dubbed the nucleus, for protection. The nucleus is a high-security castle: only specific molecules are allowed in and out to deliver DNA instructions to the outside world—for example, to protein-making factories in the cell that translate genetic instructions into proteins.
At the heart of regulating this traffic are nuclear pore complexes, or NPCs (wink to gamers). They’re like extremely intricate drawbridges that strictly monitor the ins and outs of molecular messengers. In biology textbooks, NPCs often look like thousands of cartoonish potholes dotted on a globe. In reality, each NPC is a massively complex, donut-shaped architectural wonder, and one of the largest protein complexes in our bodies.
Incredible Virus Discovery Offers Clues About the Origins of Complex Life
Omuterema AkhahendaAdmin.
I remember when my friends worked at a Motorola Chip fabrication plant in San Antonio. They had the facilities, as well as skilled labor. However, cheaper labor led many to invest abroad. I even changed my major from computer science, as I heard of thi… See more.
Anne KristoffersenWell — Orbital semiconductor fabrication should be pursued, there are so many benefits to making chips in a naturally micro-gravity, hard-vacuum environment.
Notably, you aren’t using any water, and your silicon wafers can be arbitrarily large.… See more.
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Chinese Scientists Create System to Care For Embryos in Artificial Womb
Parents of the future rejoice! Scientists in China have developed an AI nanny that they say could one day take care of human fetuses in a lab.
Researchers in Suzhou, China, claim to have created a system that can monitor and care for embryos as they grow into fetuses while growing inside an artificial womb, The South China Morning Post reports.
