Lifeboat Foundation

COVID-19 may be just the beginning of mass pandemics.

Vir Biotechnology, a San Francisco-based biotechnology firm, said Wednesday that laboratory testing showed two of its antibody drugs appeared to neutralize the coronavirus that causes Covid-19 and that it would pursue testing them in people.

The company said that human tests of the drugs could begin in three to five months, putting it roughly in line with two other efforts to produce anti-coronavirus antibodies. Regeneron, based in Tarrytown, N.Y., has said that its antibodies could enter trials by early summer — and that its treatment, if it proves effective, could be available for some uses in the fall. Eli Lilly, which is developing anti-SARS-CoV-2 antibodies with AbCellera, a Vancouver biotech, has said it hopes to begin human tests in four months.

“Stopping this disease will take a combination of prevention and treatment approaches,” Vir CEO George Scangos said in a statement. “At Vir, we are fortunate that our existing antibody platform gave us a running start against COVID-19, and we have the internal and partnered capabilities to work on multiple approaches.”

Topline : Thousands of at-home coronavirus antibody tests, used to detect whether someone has had and is potentially resistant to the virus, will be made available in the U.K. within days, a public health director has said, following calls for more frontline workers to be tested.

Researcher from Peking University says new treatment could stop pathological memories.

Five critically ill COVID-19 patients got better after receiving the treatment. Three have left the hospital and two are in stable condition.

A shrimp peddler at the Chinese market where the coronavirus pandemic likely began has been identified as one of the first victims of the disease — and possibly “patient zero.”

The 57-year-old woman, identified by the Wall Street Journal as Wei Guixian, was the first person from the now-notorious Huanan market in Wuhan to test positive for the deadly bug.

She was at work Dec. 10 when she developed what she thought were cold symptoms, Chinese outlet The Paper reported. So she walked to a small local clinic for treatment and then went back to work — likely spreading the contagion.

A large team of researchers affiliated with multiple institutions in and around Hangzhou, China, has taken a very large step toward the creation of a comprehensive human single-cell atlas. In their paper published in the journal Nature, the group describes how they sequenced the RNA of over a half-million single cells donated by volunteers and processed the information to present it in a way that could be used in a single-cell atlas.

All of the cells in the human body carry the same basic genetic information—they differ in which genes are expressed. Those genes that are expressed define the function of a given cell. For some time, medical researchers have wanted an atlas that would describe which genes are expressed in cells in all parts of the body. Such an atlas would help scientists better understand the functions of cells and how they work together, in addition to saving time on new research efforts. Atlases have been created for some tissue types, but currently, there is no single atlas to cover all of the cell types in the human body. Creating such an atlas would require much time and effort over many years, as the human body has over 30 trillion cells, after all. In this new effort, the researchers have taken a large step toward that goal by providing gene expression information for over 500,000 cells from different parts of the body (and some from fetal tissue), including all of the major organs.

The work involved first obtaining the tissue samples and then processing them. To that end, the cells were first isolated by putting some in a centrifuge and using enzymes with others. Once isolated, each of the cells were sequenced using a special tool the team previously developed called Microwell-seq—it allows for fast sequencing of large numbers of cells. In all, the team sequenced cells from 60 types of tissue. The researchers then generated a map using a method they devised for classifying cell information. The map and its underlying data form the basis of what could become a full, comprehensive single-cell database.

Sandia National Laboratories distinguished technical staff member Juan Elizondo-Decanini developed a new configuration for neutron generators by turning from conventional cylindrical tubes to the flat geometry of computer chips. The Neutristor is an ultra-compact, disposable, neutron generator 1000 times smaller than the closest competitor. The most practical application, and the most likely to be near-term, would be a tiny medical neutron source implanted close to a tumor that would allow cancer patients to receive a low neutron dose over a long period at home instead of having to be treated at a hospital. Elizondo-Decanini says the technology is ready to be licensed for some commercial applications, but other more complex commercial applications could take five to ten years.

In people who have recovered, plasma is teeming with antibodies that may fight the virus. But the treatment beginning in New York is experimental.