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Siva Balu — VP / Chief Information Officer — YMCA of the U.S.A. — People, Potential, & Purpose

With 2700 locations across 10000 U.S. communities, YMCA is becoming a major hub for healthy living — From vaccinations and diabetes prevention programs, to healthy aging and wellness — Siva Balu, VP/Chief Information Officer — The Y of the U.S.A.

Mr. Siva Balu is Vice President and Chief Information Officer of YMCA of the U.S. (Y-USA), where he is working to rethink and reorganize the work of the organization’s information technology strategy to meet the changing needs of Y-USA and Ys throughout the country.

The YMCA is a leading nonprofit committed to strengthening community by connecting all people to their potential, purpose and each other, with a focus on empowering young people, improving health and well-being and inspiring action in and across communities, and with presence in 10000 neighborhoods across the nation, they have real ability to deliver positive change.

Mr. Balu has 20 years of healthcare technology experience in leadership roles for Blue Cross Blue Shield, the nation’s largest health insurer, which provides healthcare to over 107 million members—1 in 3 Americans. He most recently led the Enterprise Information Technology team at the Blue Cross Blue Shield Association (BCBSA), a national federation of Blue Cross and Blue Shield companies.

Mr. Balu was responsible for leading all aspects of IT, including architecture, application and product development, big data, business intelligence and data analytics, information security, project management, digital, infrastructure and operations. He has created several highly scalable innovative solutions that cater to the needs of members and patients throughout the country in all communities. He provided leadership in creating innovative solutions and adopting new technologies for national and international users.

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Researchers discover that a mechanical cue is at the origin of cell death decision

In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic “corridor” and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.

In past studies, researchers have found that C. elegans gonads generate more germ than needed and that only half of them grow to become oocytes, while the rest shrink and die by physiological apoptosis, a that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, have found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.

Prior studies revealed the genetic basis and biochemical signals that drive physiological cell death, but the mechanisms that select and initiate apoptosis in individual germ cells remained unclear. As germ cells mature along the gonad of the nematode, they first collectively grow in size and in volume homogenously. In the study just published in Nature Physics, the scientists show that this homogenous growth suddenly shifts to a heterogenous growth where some cells become bigger and some cells become smaller.

Star Wars — Youth Biology PSA

Creepio advocates for the technological singularity… as foretold by the PROPHECY! 😉

Happy memorial day to the other Americans amongst you!

Creepio helps us get ready for Ep. 3 with a brief science lesson. Why wait, when you can learn?
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Puberty, it’s happening to you and me.

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COVID-19 Drugs: Canadian COLCORONA Study Shows That Colchicine Can Reduce Certain Complications Of COVID-19

COVID-19 Drugs: Canadian researchers from the Montreal Heart Institute (MHI) and the Université de Montréal announced the clinical trial findings of the COLCORONA study (NCT04322682), which was a phase 3, randomized, double-blind, adaptive, placebo-controlled, multicentre trial of the oral anti-inflammatory medication called Colchicine on hospitalized COVID-19 patients. The stu…

Cities Have Unique Microbial ‘Fingerprints’, First Study of Its Kind Reveals

Each city is populated by a unique host of microbial organisms, and this microbial ‘fingerprint’ is so distinctive, the DNA on your shoe is likely enough to identify where you live, scientists say.

In a new study, researchers took thousands of samples from mass transit systems in 60 cities across the world, swabbing common touch points like turnstiles and railings in bustling subways and bus stations across the world.

Subjecting over 4700 of the collected samples to metagenomic sequencing (the study of genetic material collected from the environment), scientists created a global atlas of the urban microbial ecosystem, which they say is the first systematic catalog of its kind.

Trials begin on lozenge that rebuilds tooth enamel

Before too long, you may be able to buy a breath mint that rebuilds your tooth enamel while it whitens your teeth, thanks to a team of University of Washington researchers.

The team is preparing to launch clinical trials of a lozenge that contains a genetically engineered peptide, or chain of amino acids, along with phosphorus and calcium ions, which are building blocks of tooth enamel. The peptide is derived from amelogenin, the key protein in the formation of tooth enamel, the tooth’s crown. It is also key to the formation of cementum, which makes up the surface of the tooth root.

Each lozenge deposits several micrometers of new enamel on the teeth via the peptide, which is engineered to bind to the damaged enamel to repair it while not affecting the mouth’s soft tissue. The new layer also integrates with dentin, the living tissue underneath the tooth’s surface. Two lozenges a day can rebuild enamel, while one a day can maintain a healthy layer. The lozenge – which can be used like a mint – is expected to be safe for use by adults and children alike.

New tool activates deep brain neurons

Using a mouse model, Chen and the team delivered a viral construct containing TRPV1 ion channels to genetically-selected neurons. Then, they delivered small burst of heat via low-intensity focused ultrasound to the select neurons in the brain via a wearable device. The heat, only a few degrees warmer than body temperature, activated the TRPV1 ion channel, which acted as a switch to turn the neurons on or off.

Neurological disorders such as Parkinson’s disease and epilepsy have had some treatment success with deep brain stimulation, but those require surgical device implantation. A multidisciplinary team at Washington University in St. Louis has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on and off and precisely control motor activity without surgical device implantation.

The team, led by Hong Chen, assistant professor of biomedical engineering in the McKelvey School of Engineering and of radiation oncology at the School of Medicine, is the first to provide direct evidence showing noninvasive, cell-type-specific activation of neurons in the brain of mammal by combining ultrasound-induced heating effect and genetics, which they have named sonothermogenetics. It is also the first work to show that the ultrasound-genetics combination can robustly control behavior by stimulating a specific target deep in the brain.

Results of the three years of research, which was funded in part by the National Institutes of Health’s BRAIN Initiative, were published online in Brain Stimulation May 11, 2021.

U-Smell-It honored in global $6M XPRIZE Rapid Covid Testing Competition

An XPRIZE Rapid COVID test from U smell it honored Scratch n Sniff can detect COVID-19 by Smell.

Guilford, CT, USA; U-Smell-It™ LLC, a Guilford-based company specializing in innovative COVID detection techniques, has announced that it has won the $6M XPRIZE Rapid Covid Testing, a global effort to develop breakthrough COVID testing methods.

XPRIZE Rapid COVID Testing is a $6 million dollar, 6-month competition to develop faster, cheaper, and easier to use COVID-19 testing methods at scale.

Chosen from more than 700 international companies, the XPRIZE judges awarded U-Smell-It™ the award based on scalability, ease of use, and cost.