Lifeboat Foundation

If this works that would be awesome.

It is estimated by The National Kidney Foundation that over 100,000 patients are on the waiting list for kidney donors. A further 3,000 names are added to the list every year. An average patient has to wait for 3.6 years for a viable transplant. The patients are treated with dialysis while they are waiting for a transplant and only one in three patients survive for more than five years without a transplant. All that could change as scientists have developed the world’s first artificial kidney.

Continue reading “This Artificial Kidney Eliminates The Need For Kidney Dialysis” »

STEM Bootstrapping in Bio-Medicine! — On this recent ideaXme (https://radioideaxme.com/) episode, I was joined by 24 year old Malawian inventor, Sanga Marcarios Kanthema, founder and CEO of two companies, Dolphin Health Innovations and QubiX Robotics, who’s bringing health tech innovations to one of the world’s poorest countries — #Ideaxme #Malawi #Robotics #EKG #Stethoscope #Prosthetics #MobileHealth #SmartPhones #Telemedicine #MedicalDrones #Health #Wellness #Longevity #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador and founder of Bioquark, interviews Sanga Kanthema, 24 year old electronics specialist and founder and CEO of two Malawi-based companies, Dolphin Health Innovations and QubiX Robotics.

Continue reading “How To Innovate In Biomedicine With Limited Resources For Big Results” »

US$30 Million to Seed Hundreds of Bold, Innovative Ideas for Human Longevity! — On this ideaXme (https://radioideaxme.com/) episode, I am joined by Dr. Victor Dzau, President of the U.S. National Academy of Medicine (https://nam.edu/initiatives/grand-challenge-healthy-longevity/) to talk about the potential of their Healthy Longevity Global Grand Challenge — eNag #ideaXme #VictorDzau #Wellness #Health #NationalAcademyOfMedicine #NAM #NAS #NIH #FDA #Duke #Cardiology #Longevity #Biotechnology #Regeneration #LifeExtension #Aging #Challenges #Prizes #Competitions #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador and founder of Bioquark, interviews Dr. Victor Dzau, President of the United States National Academy of Medicine (NAM)and of the United States National Academy of Sciences (NAS).

Continue reading “A US $30 million fund to promote bold ideas for aging populations: Dr Victor Dzau” »

7-Ketocholesterol is a harmful oxidized byproduct of cholesterol, it is highly toxic with no redeeming qualities and serves no purpose in our bodies aside from allowing heart disease to develop. Check out Underdog Pharma’s recent review at Science Direct to learn more!

Oxidative stress has long been causatively implicated in the aging process [219,220]. As described in section 2, 7KC is the most common stable product of a reaction between cholesterol and a free radical. This is a vicious cycle as 7KC also leads to increased free radical production and release, seemingly by plasma membrane permeabilization. As discussed above, mitochondrial dysfunction and free-radical formation are also strongly implicated in the aging process and so while the precise mechanistic links between mitochondria, 7KC, and aging are still being elucidated they seem likely to be intertwined.

Is 7KC a biomarker of aging? As discussed in section 4, 7KC accumulation is directly implicated in many diseases of aging, including atherosclerosis, heart failure, AMD, NAFLD, and AD. It is thus reasonable to hypothesize that when otherwise unrelated diseases of aging share a common cause, that this cause is likely to be a part of the biological aging process. 7KC is known to accumulate in phagocytic cells such as macrophages (promoting the formation of foam cells), RPE cells, and microglia. It has also been suggested that c. elegans subjected to 7KC could be a good model of 7KC-dependent aging [221]. As 7KC is broadly toxic, and most cells seem to have difficulty metabolizing it, it may be that, with age, 7KC is bioaccumulating and impairing functional activity of the cells and tissue.

Continue reading “7-Ketocholesterol in disease and aging” »

The Trump administration is proposing new rules to guide future federal regulation of artificial intelligence used in medicine, transportation and other industries.

But the vagueness of the principles announced by the White House is unlikely to satisfy AI watchdogs who have warned of a lack of accountability as computer systems are deployed to take on human roles in high-risk social settings, such as mortgage lending or job recruitment.

The White House said that in deciding regulatory action, U.S. agencies “must consider fairness, non-discrimination, openness, transparency, safety, and security.” But federal agencies must also avoid setting up restrictions that “needlessly hamper AI innovation and growth,” reads a memo being sent to U.S. agency chiefs from Russell Vought, acting director of the Office of Management and Budget.

It’s common for people to focus on their health at the start of the year.

But few consider the well being of the microbes that live inside the human gut – the microbiome – which are vital to an individual’s good health.

How important are these bacteria? There are as many bacterial cells in us as there are human cells, and they help control everything from inflammation and the development and treatment of cancer to how much energy we get from our foods and perhaps even what foods we crave and our moods.

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The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which paves the way to a bigger brain. This brain size gene is called ARHGAP11B and so far, how it works was completely unknown. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden now uncovered its mode of action. They show that the ARHGAP11B protein is located in the powerhouse of the cell—the mitochondria—and induces a metabolic pathway in the brain stem cells that is characteristic of cancer cells.

The research group of Wieland Huttner, a founding director of the Max Planck Institute of Molecular Cell Biology and Genetics, has been investigating the molecular mechanisms underlying the expansion of the brain during mammalian evolution for many years. In 2015, the group reported a key role for a gene that is only present in humans and in our closest extinct relatives, the Neanderthals and Denisovans. This gene, named ARHGAP11B, causes the so-called basal brain stem cells to expand in number and to eventually increase the production of neurons, leading to a bigger and more folded brain in the end. How the gene functions within the basal brain stem cells has been unknown so far.

Takashi Namba, a postdoctoral scientist in the research group of Wieland Huttner, wanted to find the answer to this question, together with colleagues from the Max Planck Institute, the University Hospital Carl Gustav Carus Dresden, and the Department of Medical Biochemistry at the Semmelweis University, Budapest. He found that the ARHGAP11B protein is located in mitochondria, the organelles that generate most of the cell’s source of chemical energy and hence are often referred to as the powerhouse of the cell. Takashi Namba explains the results: We found that ARHGAP11B interacts with a protein in the membrane of mitochondria that regulates a membrane pore. As a consequence of this interaction, the pores in the membrane are closing up, preventing calcium leakage from the mitochondria. The resulting higher calcium concentration causes the mitochondria to generate chemical energy by a metabolic pathway called glutaminolysis.

In the story of Goldilocks, a little girl tastes three different bowls of porridge to find which is not too hot, not too cold, but just the right temperature. In a study published in Advanced Therapeutics, University of Minnesota Medical School researchers report on a “Goldilocks” balance which holds the key to awakening the body’s immune response to fight off brain cancer.

The most common form of adult brain cancer is glioblastoma. Doctors diagnose about 14,000 glioblastoma cases in the U.S. each year. This aggressive cancer has claimed the lives of Senators John McCain and Edward Kennedy.

“Our body has armies of white blood cells that help us fight off bacteria, viruses and cancer cells. This constellation of cells constitute our immune system,” said senior author Clark C. Chen, MD, Ph.D., Lyle French Chair in Neurosurgery and Head of the Department of Neurosurgery at the University of Minnesota Medical School. “One of the key reasons why glioblastoma is so aggressive is that it shuts off this immune system.”