Lifeboat Foundation

❄7th Day of Christmas ❄!!!

On the 7th Day of Christmas, we celebrate a wonderful healing journey.

Past Stage 4 CHIPSA patient Dalilah, shrank her tumor in just 3 weeks.

Continue reading “Tumor Shrinkage In Just 3 Weeks!” »

Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or chemicals that can damage DNA, such as chemotherapy. The results, published online in Nature Metabolism on December 9, 2019, could lead to new cancer treatments that prevent tumors from becoming resistant to chemotherapy.

“Mitochondria are acting as a first line of defense in sensing DNA stress. The mitochondria tell the rest of the cell, ‘Hey, I’m under attack, you better protect yourself,’” says Gerald Shadel, a professor in Salk’s Molecular and Cell Biology Laboratory and the Audrey Geisel Chair in Biomedical Science.

Most of the DNA that a cell needs to function is found inside the cell’s nucleus, packaged in chromosomes and inherited from both parents. But mitochondria each contain their own small circles of DNA (called mitochondrial DNA or mtDNA), passed only from a mother to her offspring. And most cells contain hundreds — or even thousands — of mitochondria.

Scientists have developed a new gene-therapy technique by transforming human cells into mass producers of tiny nano-sized particles full of genetic material that has the potential to reverse disease processes.

Though the research was intended as a proof of concept, the experimental therapy slowed tumor growth and prolonged survival in mice with gliomas, which constitute about 80 percent of malignant brain tumors in humans.

The technique takes advantage of exosomes, fluid-filled sacs that cells release as a way to communicate with other cells.

After decades of research, here it is: the first promising evidence in humans, albeit imperfect and early, that a cocktail of three drugs is enough to reverse the epigenetic clock—a measure of someone’s biological age and health.

The results came as a surprise to even the research team, who originally designed the trial for something a little less dazzling: to look at human growth hormone’s effects on the thymus, the cradle of the body’s immune system that deteriorates with age.

“Maintained immune function is seen in centenarians,” and thymus function is linked to all-cause mortality, explained study author Dr. Gregory Fahy at Intervene Immune, based in Los Angeles, California. “So we were hoping to use a year of growth hormone to maintain thymus function in middle-aged men, right before the tissue’s functions take a nosedive,” he said.

For the December edition of the Journal Club hosted by Dr. Oliver Medvedik, we are joined by Dr. Matthew O’ Connor (Oki) formerly of SENS Research Foundation and now the head researcher at Underdog Pharma, a spin-off biotech company that is developing research conducted at SENS into a hopefully viable solution for heart disease.

Dr. O’Connor will be giving a short presentation covering the story of 7-Ketocholesterol, a harmful byproduct of oxidized cholesterol that Underdog believes is a suitable target for therapeautic intervention to prevent the formation of artery plaques, the basis of atherosclerosis. Then, we will review the new paper that his team has published and follow it up with discussion and questions.

Yes, the simple act of juggling has recently been linked with better brain function. A new study reveals that learning to juggle may cause certain areas of your brain to grow.

The study found that volunteers who participated in a juggling exercise improved white matter in two areas of their brains involved in visual and motor activity.

‘We have demonstrated that there are changes in the white matter of the brain — the bundles of nerve fibres that connect different parts of the brain — as a result of learning an entirely new skill,’ explains Dr Heidi Johansen-Berg of the Department of Clinical Neurology, University of Oxford, who led the work.

For many years, chili has been hailed for its therapeutic properties, and now researchers have found that eating chili peppers regularly can cut the risk of death from heart disease and stroke.

Carried out in Italy, where chili is a common ingredient, the study compared the risk of death among 23,000 people, some of whom ate chili and some of whom didn’t.

An organized tide of brain waves, blood and spinal fluid pulsing through a sleeping brain may flush away neural toxins that cause Alzheimer’s and other diseases.

A small study reveals that rapamycin, a drug with a long history as an immune suppressor, can improve tone and reduce wrinkles and sagging in human skin.