Lifeboat Foundation

Methylation clocks are far and away the most accurate markers of a person’s age, and so are a promising tool for evaluating anti-aging interventions, but they are a bit of a black box. We know from statistics that certain places on chromosomes become steadily methylated ( or demethylated ) with age, but we often don’t know what effect that has on expression of particular genes.

For the first time, a clock has been devised based on proteins in the blood that is comparable in accuracy to the best methylation clocks. This has the advantage of being downstream of epigenetics, so it is less of a black box. What can we learn from the proteins that are increased ( and decreased ) with age?

I’ve written often and enthusiastically about the utility of methylation clocks for evaluation of anti-aging interventions [ blog, blog, blog, journal article ]. This technology offers a way to promptly identify small age-reversal successes (perhaps not in individuals, but averaged over a cohort of ~50 to 100 subjects). Before these tests were available, we had no choice but to wait — usually 10 years or more — for enough experimental subjects to die that we could be sure the intervention we were evaluating affected life expectancy. (This is the plan of the worthy but ridiculously expensive TAME trial promoted by Nir Barzilai.)

We are thrilled to announce the findings of the latest research study from Amsterdam Medical Center about the impact of the Wim Hof Method on auto-immune disease. The results are truly impressive. A new milestone has been reached! Shedding light on our human potential. Stay Happy, Strong and Healthy & Make sure to check out the FULL VIDEO and learn all about this latest study at the link below: http://ow.ly/kcSg50xtwfW… #iceman #wimhof #science #research #study #inflammation #immunesystem #breath #cold #mindset #wimhofmethod #stronghappyhealthy

2019 was nuts for neuroscience. I said this last year too, but that’s the nature of accelerating technologies: the advances just keep coming.

There’re the theoretical showdowns: a mano a mano battle of where consciousness arises in the brain, wildly creative theories of why our brains are so powerful, and the first complete brain wiring diagram of any species. This year also saw the birth of “hybrid” brain atlases that seek to interrogate brain function from multiple levels—genetic, molecular, and wiring, synthesizing individual maps into multiple comprehensive layers.

Brain organoids also had a wild year. These lab-grown nuggets of brain tissue, not much larger than a lentil, sparked with activity similar to preterm babies, made isolated muscles twitch, and can now be cloned into armies of near-identical “siblings” for experimentation—prompting a new round of debate on whether they’ll ever gain consciousness.

You heard about reversing the epigenetic clock 2.5 years? Living drugs? CAR T cells? Fight cancer? Here ya go.

Vision Weekend is the annual member gathering of Foresight Institute, a non-profit for advancing beneficial technologies for the long-term flourishing of life.

Continue reading “Zinaida Good | Reversing Epigenetic Aging and Immunosenescent Trends in Humans | VISION WEEKEND 2019” »

Research led by the University of California, Los Angeles (UCLA) has uncovered a new process that may help explain how Type 2 diabetes develops. In tests on live mice and human cells in the lab, the team found a new mechanism besides insulin resistance and high glucose levels that triggers pancreatic cells to begin overproducing insulin.

Type 2 diabetes is the form of the disease that’s usually a result of lifestyle choices, such as poor diet and not enough exercise. It involves a kind of vicious cycle of insulin – beta cells in the pancreas produce too much insulin, which causes the body to become resistant to it. That in turn means the beta cells could produce even more to compensate.

It was long thought that high glucose levels – most commonly caused by eating too much sugary and fatty foods – was the trigger for the beta cells to begin overproducing insulin. But it’s also been shown in the past that even beta cells isolated in a lab dish can over-secrete insulin, without glucose playing a part.

An Ontario woman who was part of a U.S. study on experimental spinal stimulators similar to the device implanted in a paralyzed Humboldt Broncos player in Thailand says the device should be tested in Canada where it is not approved for use.

Researchers from MIT have revealed the very first images of a human generated through a novel laser ultrasound imaging technique. Unlike conventional ultrasound, the new technique does not require any skin contact with the body, dramatically amplifying the range of uses for doctors in clinical environments.

A conventional ultrasound is one of the cheapest and easiest imaging methods clinicians currently have in their arsenal. Unlike X-ray or CT scans, an ultrasound does not involve harmful radiation, and unlike PET or MRI scans, there is no need for large expensive machines. Of course, ultrasound does have a number of limitations, from the need for significant bodily contact in the process of imaging, to a variability in imaging results.

A new non-contact ultrasound method involving lasers has now been effectively demonstrated by a team of researchers from MIT. The challenge in developing the new method has been figuring out a way to use a laser to produce sound waves. Traditional ultrasound uses sound waves to penetrate a human body and bounce back off different tissues. Light, of course, cannot penetrate a human body as deeply as sound.

Let nobody tell you that the second decade of the 21st century has been a bad time. We are living through the greatest improvement in human living standards in history. Extreme poverty has fallen below 10 percent of the world’s population for the first time. It was 60 percent when I was born. Global inequality has been plunging as Africa and Asia experience faster economic growth than Europe and North America; child mortality has fallen to record low levels; famine virtually went extinct; malaria, polio and heart disease are all in decline.

Little of this made the news, because good news is no news. But I’ve been watching it all closely. Ever since I wrote The Rational Optimist in 2010, I’ve been faced with ‘what about…’ questions: what about the great recession, the euro crisis, Syria, Ukraine, Donald Trump? How can I possibly say that things are getting better, given all that? The answer is: because bad things happen while the world still gets better. Yet get better it does, and it has done so over the course of this decade at a rate that has astonished even starry-eyed me.

Perhaps one of the least fashionable predictions I made nine years ago was that ‘the ecological footprint of human activity is probably shrinking’ and ‘we are getting more sustainable, not less, in the way we use the planet’. That is to say: our population and economy would grow, but we’d learn how to reduce what we take from the planet. And so it has proved. An MIT scientist, Andrew McAfee, recently documented this in a book called More from Less, showing how some nations are beginning to use less stuff: less metal, less water, less land. Not just in proportion to productivity: less stuff overall.

Novartis is offering a $250,000 prize to fund development of pioneering innovation with great potential in advancing Assistive Tech for Multiple Sclerosis. Applications will be accepted until January 10, 2020, and the winners will be announced during a panel discussion among experts in the field at SXSW in Austin, TX.