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Category: biotech/medical – Page 19

Brad Younggren | Therapeutic Plasma Exchange (TPE): A Tool Against Aging and Disease

Offering TPE. I do not see a cost though.

*Apply to join Foresight Biotech & Health Extension program:* https://foresight.org/biotech-health-extension-program/
A group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This group is sponsored by 100 Plus Capital. http://100pluscap.com/

*Foresights Personal Longevity Group* Exploring anti-aging methods, monthly virtual meetings, expert discussions, private group for Foresight Patrons. https://foresight.org/personal-longevity-group/

*Brad Younggren | Therapeutic Plasma Exchange (TPE): A Tool Against Aging and Disease*
Bio: Brad Younggren, MD, is CEO and co-founder of Circulate Health, a company dedicated to extending human healthspan. A former U.S. Army physician, Dr. Younggren served as a combat physician in Iraq and was awarded a Bronze Star and Combat Medical Badge. An emergency medicine specialist and seasoned healthcare executive, Younggren has led teams at the cutting edge of medicine for decades. Most recently, he was President and Chief Medical Officer at 98point6, where he led the development and launch of AI-powered primary care solutions. He previously served as CMO at Cue Health, Shift Labs, and Mobisante. At Circulate, Younggren leads an expert team of clinicians and scientists working to harness the potential of therapeutic plasma exchange to advance health and longevity.
https://www.circulate.health/

Abstract: Aging is the primary risk factor for most chronic diseases, driving over 90% of U.S. healthcare expenditures. However, emerging science suggests that aging itself can be targeted as a modifiable process. Therapeutic Plasma Exchange (TPE) is a promising intervention that removes harmful substances from the bloodstream, reducing inflammation, disease burden, and potentially reversing aspects of biological aging. Circulate Health is pioneering this space, with clinical trial data demonstrating measurable reductions in biological age and improvements in key biomarkers. Beyond its longevity benefits, recent findings suggest TPE may help reduce microplastics and other environmental toxins—offering a practical, scalable approach to mitigating modern health threats. In this talk, we’ll explore the science behind TPE, its clinical applications, and why Circulate Health’s model makes this groundbreaking treatment accessible to more patients and clinics.

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AlphaGenome: AI for better understanding the genome

Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.

The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter an organism’s response to its environment or its susceptibility to disease. But deciphering how the genome’s instructions are read at the molecular level — and what happens when a small DNA variation occurs — is still one of biology’s greatest mysteries.

Today, we introduce AlphaGenome, a new artificial intelligence (AI) tool that more comprehensively and accurately predicts how single variants or mutations in human DNA sequences impact a wide range of biological processes regulating genes. This was enabled, among other factors, by technical advances allowing the model to process long DNA sequences and output high-resolution predictions.

New system uses sound and terahertz waves to measure blood sodium without needles

In a new study, researchers demonstrate long-term, non-invasive monitoring of blood sodium levels using a system that combines optoacoustic detection with terahertz spectroscopy. The paper is published in the journal Optica.

Accurate measurement of blood is essential for diagnosing and managing conditions such as dehydration, kidney disease and certain neurological and endocrine disorders.

Terahertz radiation, which falls between microwaves and the mid-infrared region of the electromagnetic spectrum, is ideal for biological applications because it is low-energy and non-harmful to tissues, scatters less than near-infrared and visible light and is sensitive to structural and functional biological changes.

Role of tumor microenvironment in nasopharyngeal carcinoma progression uncovered

A study led by clinician-scientists and researchers at the National Cancer Centre Singapore (NCCS) has found that the tumor immune microenvironment (TIME) plays a critical role in the progression of nasopharyngeal carcinoma (NPC) commonly known as nose cancer. These insights are paving the way for precision oncology approaches, some of which are currently used in clinical trials at NCCS. The findings are published in Cell Reports Medicine.

NPC is a type of head and that originates in the nasopharynx—the passageway behind the nose. It is prevalent in Southeast Asia, Southern China and North Africa and occurs more frequently in men. In Singapore, NPC is the 10th leading cause of cancer death in men and is the third most common cancer in men aged 30 to 49.

Due to the anatomy of the nasopharynx, NPC often spreads insidiously and is typically diagnosed at a locoregionally advanced stage, where cancer has spread within the head but not to distant parts of the body.

UChicago scientists invent breakthrough device to detect airborne signs of disease

If you’ve ever sat waiting at the doctor’s office to give a blood sample, you might have wished there was a way to find the same information without needles.

But for all the medical breakthroughs of the 20th century, the best way to detect molecules has remained through liquids, such as blood. New research from the University of Chicago, however, could someday put a pause on pinpricks. A group of scientists announced they have created a small, portable device that can collect and detect airborne molecules—a breakthrough that holds promise for many areas of medicine and public health.

The researchers envision the device, nicknamed ABLE, could detect airborne viruses or bacteria in hospital or public spaces, improve neonatal care or allow people with diabetes to read glucose levels from their breath. The entire device is just four by eight inches across.

Portable tech captures molecules in breath to aid medical care from diabetes to at-risk newborn development.

Groundbreaking project to make artificial human DNA begins

In a groundbreaking development, scientists have started working on the building blocks of human life from scratch.

The project, dubbed the Synthetic Human Genome Project, is being funded by London-based Wellcome Trust, the World’s largest medical charity, with an initial investment of £10 million (approximately $12.7 million).

The research has been largely considered taboo due to fears that it could lead to designer babies or unintended consequences for future generations.

(That’s not my taboo. Creating Synthetic DNA can lead to the creation of synthetic humans. It can be useful in stopping wildlife extinction, but we don’t know the implications of what happens when we do. TheThe BBC also reported on this. Link in comments)

Work has started on a groundbreaking, yet contentious, project to create artificial human DNA from scratch, marking a potential world first.