Lifeboat Foundation

Gene editing is advancing at a faster pace than most of us can keep up with. One significant recent announcement was gene editing tool CRISPR’s application to non-genetic diseases thanks to a new ability to edit single letters in RNA.

Even as CRISPR reaches milestones like this, scientists continue to find new uses for it to treat genetic conditions. The next one that will hit clinics is a CRISPR treatment for a form of blindness called Leber congenital amaurosis (LCA).

Having been approved by the FDA in December, the treatment will be the first of its kind to be trialed in the US.

Scientists at work in laboratory. Photo: Public domain via Wikicommons.

CTech – When chemistry Nobel laureate Michael Levitt met his wife two years ago, he didn’t know it would lead to a wonderful friendship with a young Israeli scientist. When Israeli scientist Shahar Barbash decided to found a startup with the aim of cutting down the time needed to develop new medicine, he didn’t know that a friend’s wedding would help him score a meeting with a man many want to meet but few do. But Levitt’s wife is an old friend of Barbash’s parents, and the rest, as they say, is history.

One of the joys of being an old scientist is to encourage extraordinary young ones, Levitt, an American-British-Israeli biophysicist and a professor at Stanford University since 1987, said in a recent interview with Calcalist. He might have met Barbash because his wife knew his family, but that is not enough to make him go into business with someone, Levitt said. “I got on board because his vision excited me, even though I thought it would be very hard to realize.”

An international team of researchers has found that the gut microbiota in mice play an influential role in skeletal muscle mass maintenance and function. In their paper published in the journal Science Translational Medicine, the group describes their experiments with wild and lab-raised mice, and what they found.

Over the past several years, scientists have found that gut microbiota in humans and other animals play a far bigger role in maintaining health than previously thought. In addition to processing food, the gut microbiome plays an important role in immunity and in regulating cholesterol and triglycerides. And imbalances in the gut microbiota have been associated with conditions such as Crohn’s disease, IBS and other inflammatory diseases. Now, the researchers with this new effort have found evidence that suggests the gut microbiome also plays a role in maintaining the right amount of skeletal muscle mass and its function—at least in mice.

Skeletal muscle is one of the three main types of muscle—the other two are cardiac and smooth. Skeletal muscle is very much what it sounds like—the collection of muscles that are connected to bones in the skeleton that control movement, most specifically, the limbs.

MILWAUKEE (AP) — A British cybersecurity expert credited with helping stop a worldwide computer virus in May 2017 won’t serve any additional time behind bars for creating malware years before he won international acclaim.

U.S. District Judge J.P. Stadtmueller sentenced 25-year-old Marcus Hutchins on Friday in Milwaukee to time served, with a year of supervised release. Stadtmueller said the virus Hutchins helped stop was far more damaging than the malware he wrote.

Hutchins pleaded guilty in May to developing and conspiring to distribute malware called Kronos from 2012 to 2015. Prosecutors dismissed eight charges in exchange for his plea.

On Friday afternoon, a volcano in southern Indonesia erupted, spewing ash as high as 650 feet into the air, according to the country’s National Board for Disaster Management.

The ash from the eruption of Mount Tangkuban Parahu landed as far as 6,500 feet away, reports ABC.

The volcano is situated approximately 18.6 miles north of Indonesia’s third largest city of Bandung in West Java. As of publication, no casualties have been disclosed. However, 9News reports that two individuals were taken to the hospital with “breathing difficulties.”

The bacteria, known as Pseudomonas aeruginosa, is found widely in the environment. Infections usually occur among people with weakened immune systems—and most often in hospitals—according to the Centers for Disease Control and Prevention (CDC.)

The Utah Department of Health (UDOH) say that the deceased patient—who has not been named to protect the privacy of the family—is the latest of eight reported cases of citizens of the state becoming infected with P. aeruginosa after traveling to Tijuana for similar procedures. Fortunately, all of the other patients recovered from their infections.

Interviews with the surviving patients revealed that seven of the eight—including the one who died—had visited the same surgeon, Mario Almanza, for their procedures. Furthermore, five of the patients said that they had been referred to this surgeon by a medical tourism agency known as “Weight Loss Agents.”

By Chelsea Whyte

Tiny self-propelled capsules shed their outer shells and deliver drugs directly to tumour cells. These microrobots, demonstrated in mouse intestines, could one day be targeted treatments for cancers in hard-to-reach places in the body.

“When the capsule reaches the tumour, we can activate it, break the capsule, release the micromotors and they will move around the tumour area. That motion is very important for drug delivery,” says Wei Gao at the California Institute of Technology.

Imagine a patient controlling the movement of his or her prosthetic limb simply by thinking of commands. It may sound like science fiction but will soon become reality thanks to the EU-funded DeTOP project. A consortium of engineers, neuroscientists and clinicians has made great strides in further developing the technology behind more natural and functional prostheses.

The team uses an osseointegrated human-machine gateway (OHMG) to develop a physical link between a person and a robotic prosthesis. A patient in Sweden was the first recipient of titanium implants with the OHMG system. The OHMG is directly fitted to bones in the user’s arms, from which electrodes to nerves and muscle extract signals to control a robotic hand and provide tactile sensations. According to a news item by “News Medical,” the patient will begin using a training prosthesis in the next few months before being fitted with the new artificial hand developed by DeTOP partners. This will help the team evaluate the entire system, including the implanted interface, electronics, as well as wrist and hand functions. Motor coordination and grip strength will also be assessed during the tests.

From interpreting CT scans to diagnosing eye disease, artificial intelligence is taking on medical tasks once reserved for only highly trained medical specialists — and in many cases outperforming its human counterparts.

Now AI is starting to show up in intensive care units, where hospitals treat their sickest patients. Doctors who have used the new systems say AI may be better at responding to the vast trove of medical data collected from ICU patients — and may help save patients who are teetering between life and death.