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Archive for the ‘biotech/medical’ category: Page 1955

Apr 5, 2019

“The Mice Became Smarter”: New Treatment Restores Aging Brains

Posted by in categories: biotech/medical, life extension, neuroscience

Scientists at Stanford University say they’ve devised antibodies that block a specific gene related to brain aging — and that it’s giving old mice the cognitive prowess of younger ones.

“The mice became smarter,” senior author Tony Wyss-Coray said in a statement. “Blocking [the gene] CD22 on their microglia restored their cognitive function to the level of younger mice. CD22 is a new target we think can be exploited for treatment of neurodegenerative diseases.”

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Apr 5, 2019

Can human mortality be hacked?

Posted by in categories: bioengineering, biotech/medical, life extension, nanotechnology, robotics/AI, transhumanism

A fringe group of scientists and tech moguls think they’re closing in on the fountain of youth. Here’s everything you need to know:

What is biohacking? Silicon Valley is built on the idea that technology can optimize, or “hack,” any aspect of our lives — so why not the human life span? Until recently, anyone hawking pills or treatments that promised to restore youthfulness was considered a quack, yet a growing number of “transhumanists” are convinced that, in time, human beings can be transformed through bioengineering, and that aging will be curable just like any other malady.

In light of rapid gains in gene editing, nanotechnology, and robotics, some futurists expect this generation’s biohackers to double their life spans. Aubrey de Grey, a regenerative medicine researcher backed by tech mogul Peter Thiel, insists that someone alive today will live to be 1,000. “It’s extraordinary to me that it’s such an incendiary claim,” de Grey says. Korean physician and financier Joon Yun has offered two $500,000 prizes to anyone who can restore a test animal’s youthful heart rate and extend its lifespan by 50 percent. For humans, the mortality rate at age 20 is 0.001 percent, Yun figures, “so if you could maintain the homeostatic capacity of that age throughout your life, your average life span would be 1,000.”

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Apr 5, 2019

A light-based carrier system for CRISPR-Cas9 gene editing

Posted by in categories: bioengineering, biotech/medical, genetics, nanotechnology

A team of researchers from Nanjing and Xiamen Universities in China has developed an alternative to using viruses to transport CRISPR-Cas9 gene editing tools into a desired cell—and it involves two types of light. In their paper published in the journal Science Advances, the group describes their new type of carrier and how well it worked with test mice.

CRISPR-Cas9 gene editing tools are a coming revolution in treating genetic conditions, and scientists continue to test their abilities in a variety of applications. One area of study has involved looking for a replacement carrier system—the current approach uses a virus to carry the gene editing tool into a particular cell. Early on, researchers knew that the virus approach was not viable because of possible responses from the , or worse, the threat of initiating tumors. In this new effort, the team in China has come up with an entirely new way to deliver the gene editing tool using two kinds of light.

Their carrier system consists of nanoparticles that are sensitive to low-energy near– (NIR) and that emit UV light. When NIR is shone on the nanoparticles, the light is absorbed and converted to UV light, which is emitted. Inside of a cell, the package is activated by shining NIR onto the skin, where it penetrates into the body and makes its way to the gene editing tool. When the NIR is converted to UV light, it cuts molecules in the carrier package, releasing the gene editing tool to do its work.

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Apr 5, 2019

First-of-Its-Kind HIV Therapy Draws out the Virus, Then Kills It

Posted by in category: biotech/medical

HIV is a sneaky virus. It can hide in the immune cells of people taking daily antiretroviral therapy (ART) drugs, waiting until they stop the therapy to come back with a vengeance.

This forces them to continue ART — and continue dealing with its many side effects — for their entire lives.

But now, researchers from the University of Pittsburgh have developed an HIV immunotherapy that not only kicks the virus out of hiding, but also kills it permanently — the first step, they say, to an HIV vaccine.

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Apr 5, 2019

Getting a big look at tiny particles

Posted by in categories: biotech/medical, nuclear energy, quantum physics, supercomputing

At the turn of the 20th century, scientists discovered that atoms were composed of smaller particles. They found that inside each atom, negatively charged electrons orbit a nucleus made of positively charged protons and neutral particles called neutrons. This discovery led to research into atomic nuclei and subatomic particles.

An understanding of these ’ structures provides crucial insights about the forces that hold matter together and enables researchers to apply this knowledge to other scientific problems. Although electrons have been relatively straightforward to study, protons and neutrons have proved more challenging. Protons are used in medical treatments, scattering experiments, and fusion energy, but nuclear scientists have struggled to precisely measure their underlying structure—until now.

In a recent paper, a team led by Constantia Alexandrou at the University of Cyprus modeled the location of one of the subatomic particles inside a , using only the basic theory of the strong interactions that hold matter together rather than assuming these particles would act as they had in experiments. The researchers employed the 27-petaflop Cray XK7 Titan supercomputer at the Oak Ridge Leadership Computing Facility (OLCF) and a method called lattice quantum chromodynamics (QCD). The combination allowed them to map on a grid and calculate interactions with high accuracy and precision.

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Apr 5, 2019

Agriculture: Machine learning can reveal optimal growing conditions to maximize taste, other features

Posted by in categories: biotech/medical, chemistry, food, genetics, information science, robotics/AI

What goes into making plants taste good? For scientists in MIT’s Media Lab, it takes a combination of botany, machine-learning algorithms, and some good old-fashioned chemistry.

Using all of the above, researchers in the Media Lab’s Open Agriculture Initiative report that they have created that are likely more delicious than any you have ever tasted. No is involved: The researchers used computer algorithms to determine the optimal growing conditions to maximize the concentration of flavorful molecules known as .

But that is just the beginning for the new field of “cyber agriculture,” says Caleb Harper, a principal research scientist in MIT’s Media Lab and director of the OpenAg group. His group is now working on enhancing the human disease-fighting properties of herbs, and they also hope to help growers adapt to changing climates by studying how crops grow under different conditions.

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Apr 5, 2019

A Mushroom Extract Might Save Bees From a Killer Virus

Posted by in category: biotech/medical

Circa 2018


Two types of mushroom seem to help bees fight a major virus contributing to colony collapse disorder.

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Apr 5, 2019

New surgical method promises to take the knife out of plastic surgery

Posted by in categories: biotech/medical, materials

Simple electrical procedure could reshape noses and correct vision.

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Apr 5, 2019

Therapy that Dramatically Slows Alzheimer’s has Passed Final Clinical Phase

Posted by in categories: biotech/medical, neuroscience

Through a new approach dubbed AMBAR, the biotechnology company Grifols has attempted to reduce the amount of harmful, Alzheimer’s disease-causing amyloid beta in the brain by collecting it with a blood protein called albumin and draining it out of the bloodstream. This approach differs from the previous antibody and catabody approaches and offers new hope for sufferers of this neurodegenerative disease.

What is Alzheimer’s disease?

Alzheimer’s disease, named after its discoverer, is a slow and progressive disease that causes the degradation of the brains of its sufferers. This leads to memory loss, a decrease in problem-solving abilities, changes in personality, and other symptoms. It is associated with the accumulation of tau and amyloid beta in the brain.

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Apr 5, 2019

An Interview with Yuri Deigin of Youthereum Genetics

Posted by in categories: biotech/medical, genetics, life extension

At the Undoing Aging 2019 conference, we had the opportunity to interview Yuri Deigin, the CEO of Youthereum Genetics. His company is developing therapies that focus on OSKM, the Yamanaka factors known for turning cells back into a pluripotent state. By partially reprogramming cells using a single component of OSKM, Oct4, the company hopes to remove epigenetic aging from cells while still allowing them to retain their normal functions.

Do you think epigenetic alterations are a cause or a consequence of aging, and why?

Well, this question has so many different parts that need to be addressed. Of course, there are alterations that are consequences. Some of the epigenetics are consequences of aging, like epigenetic drift, with things that aren’t methylated in cells, as they divide throughout the lifetime, that methylation seems to get diluted away with subsequent divisions, but other parts of the genome, many of the epigenetic changes that happen that we can track throughout the aging of an organism are definitely not consequences of aging; they’re actually, from what I understand, causes of aging or causes in the change of metabolism and change of homeostasis, change how the organism behaves, essentially, that are driven by some high program in animal development, that basically silences some genes and activates other genes.

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