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Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal

I remember questioning this data, as it was not even research on animals, it was observation of people’s medical files.

Three unlikely collaborators are at the heart of the fast-moving COVID-19 research scandal, which led to retractions last week by The Lancet and The New England Journal of Medicine (NEJM), and the withdrawal of an online preprint, after the trove of patient data they all relied on was challenged. The three physician-scientists never were at the same institution nor had they ever before written together, but they are the only authors in common on the disputed papers, and the other co-authors all have ties to at least one of them. Their partnership, which seized a high-impact role during a global public health crisis, has now ended disastrously.

The first author for both retracted papers was cardiac surgeon Mandeep Mehra, an eminent Harvard University professor who works at Brigham and Women’s Hospital (BWH) and is known internationally for cardiovascular medicine and heart transplants. He provided the kind of gravitas that can fast-track papers to leading journals. In a statement provided by BWH, Mehra said he had met another of the trio, cardiac surgeon Amit Patel, in “academic and medical circles,” and that Patel had introduced him to Sapan Desai, a vascular surgeon and founder of Surgisphere, the tiny company that supplied the data. Journal disclosures, however, also indicate Mehra received compensation from Triple-Gene, a gene therapy company Patel co-founded to develop cardiovascular treatments.


Author partnership on coronavirus papers is “completely bizarre” and should have been a red flag, former journal editor says.

Essential components of dietary restriction revealed

Another link on diet/healthspan.


Studies by Monash Biomedicine Discovery Institute (BDI), have provided a new understanding into the roles two essential amino acids play in metabolic health, which may help scientists in the fight against obesity.

Led by Dr. Adam Rose, the recent finding, published in Nature Communications, shows that by reducing the amount of two —threonine and tryptophan—in young healthy mice, they were able to burn more calories than they consumed, without calorie reduction, keeping them lean and healthy and without the side-effect of lower muscle mass. A low-threonine even protected mice that were morbidly obese and prone to developing type 2 diabetes.

While a moderate reduction in dietary protein and therefore can enhance vitality, diets devoid of this component can make people sick very quickly and are not recommended. However, this study has shown that a reconsideration of the functions of these two amino acids in nutrition warrants further exploration.

Minneapolis Manufacturing Company Will Leave City after Plant Burned in Riots

A Minneapolis manufacturing company whose plant was set on fire by rioters plans to leave the city, saying that city officials afforded them no assistance in handling the destruction.

“They don’t care about my business,” 7-Sigma Inc.’s president and owner, Kris Wyrobek, told The Star Tribune about Minneapolis public officials. “They didn’t protect our people. We were all on our own.”

The 7-Sigma plant in south Minneapolis, which the company has maintained since 1987, shut down several hours early around 7 p.m. instead of 11 p.m. as a precautionary measure on the first night of rioting. The company manufactures several products, including rollers for high-speed printing presses and medical training mannequins.

Large Study Suggests Blood Type O May Be a Protective Factor Against COVID-19

The personal genomics and biotechnology company 23andMe is perhaps best known for its home DNA testing kits, whereby consumers can learn about their genetic make-up or ancestry.

However, after the COVID-19 outbreak was declared a global pandemic, the company switched gears and looked to see how their gene testing services could offer a helping hand in understanding the disease’s pathophysiology.

One aspect of COVID-19 that has puzzled scientists and clinicians alike is why, when infected with SARS-CoV-2, do some patients display mild to moderate symptoms (or no symptoms at all), whereas other patients develop severe symptoms that can prove fatal?

Video: Scientists grow a human ear with new, skin-crawling 3D printing method

Their new approach to 3D bioprinting and allows for non-invasive tissue growth and wound healing. It works through injecting bioink cells, the additive material traditionally used in 3D bioprinting, under the skin and using near-infrared light to penetrate the tissue and transfer customizable building designs — like an ear or an abstract shape — to newly injected cells.

The ear began to form in just 20 seconds.


Using a new approach to 3D bioprinting researchers have designed a way to non-invasively grow a wide range of customizable tissue under living skin.

How a fungus turns ants into zombies

Everyone knows that the great and power omnipresent mushroom that lives across the universe able to survive even in space.


Researchers have elucidated the molecular mechanism of the fungus that turns ants into living zombies. The fungus specifically affects the ants’ neurobiology, odor perception and biological clock. The Utrecht microbiologist Robin Ohm publishes this, together with American and German colleagues, in G3.

The Ophiocordyceps camponoti-floridani can infect and manipulate their in a way that is beneficial for fungus growth and transmission. These infected ants are called “zombie ants.” Influenced by the fungus, the ants climb to a high point and bite into a branch, attaching themselves until death. The fungus then digests the ant and forms a fruitbody with which the fungus spreads its spores. The behind this behavioral modification are still largely unknown, as in similar parasitic interactions in which the behavior of a host is manipulated.

“We can realistically recreate this interaction between the fungus and the ant in the lab. We have sequenced the genome of the fungus and determined all its . This gives us an important tool with which we can examine this system in detail,” says fungal researcher Robin Ohm of Utrecht University. “We then looked at the expression of all genes in the fungus and the ant during the behavioral modification. In this way, you get a good picture of the genes of both the fungus and the ant that may be involved in the behavioral modification.”

Texas Reports Record-Breaking COVID-19 Hospitalizations As State Reopens

Guessing things are about to get dicey.


Texas reported a record-breaking number of COVID-19 hospitalizations Monday as the governor plans to reopen more businesses and double capacity.

Texas Department of State Health Services figures show 1,935 people were admitted as hospital patients for coronavirus-related treatment. That is up from a previous record of 1,888 on May 5.

The department’s new figures were released as Gov. Greg Abbott moves forward with a plan to open bars, restaurants, amusement parks and other businesses to 50% capacity.

Moderna: Category: RNA, VAX

Type: Novel lipid nanoparticle (LNP)-encapsulated mRNA vaccine encoding for a prefusion stabilized form of the Spike (S) protein.

Status: Moderna said May 29 the first patients in both cohorts were dosed in the company’s Phase II trial (NCT04405076) assessing mRNA-1273. The study is designed to evaluate the safety, reactogenicity and immunogenicity of two vaccinations of mRNA-1273, given 28 days apart. plans to enroll 600 healthy participants across two cohorts: 300 adults ages 18–55 years, and 300 ages 55 years and up. Participants will be assigned to placebo, a 50 μg or a 100 μg dose at both vaccinations, and will be followed through 12 months after the second vaccination.