Amid concerns over the coronavirus pandemic, it’s important to remember the vast majority of those infected experience mild symptoms and recover from the illness.
Category: biotech/medical – Page 2,425
Researchers unlock secret of deadly brain cancer’s ‘immortality’
UC San Francisco researchers have discovered how a mutation in a gene regulator called the TERT promoter—the third most common mutation among all human cancers and the most common mutation in the deadly brain cancer glioblastoma—confers “immortality” on tumor cells, enabling the unchecked cell division that powers their aggressive growth.
The research, published September 10, 2018 in Cancer Cell, found that patient-derived glioblastoma cells with TERT promoter mutations depend on a particular form of a protein called GABP for their survival. GABP is critical to the workings of most cells, but the researchers discovered that the specific component of this protein that activates mutated TERT promoters, a subunit called GABP-ß1L, appears to be dispensable in normal cells: Eliminating this subunit using CRISPR-based gene editing dramatically slowed the growth of the human cancer cells in lab dishes and when they were transplanted into mice, but removing GABP-ß1L from healthy cells had no discernable effect.
“These findings suggest that the ß1L subunit is a promising new drug target for aggressive glioblastoma and potentially the many other cancers with TERT promoter mutations,” said study senior author Joseph Costello, Ph.D., a leading UCSF neuro-oncology researcher.
Molecular networks serve as cellular blueprints
Networks are at the heart of everything from communications systems to pandemics. Now researchers have found that a unique type of network also underlies the structures of critical cellular compartments known as membraneless organelles. These findings may provide key insights into the role of these structures in both disease and cellular operations.
“Prior to this study, we knew the basic physical principle by which these protein-rich compartments form — they condense from the cytoplasm into liquid droplets like dew on a blade of grass,” said David Sanders, a post-doctoral researcher in Chemical and Biological Engineering at Princeton University. “But unlike dew drops, which are composed of a single component (water), cellular droplets are intimidatingly complex. Our work uncovers surprisingly simple principles that we think are universal to the assembly of liquid organelles, and opens new frontiers into studying their role in health and disease.”
Sanders is the lead author in an article in the journal Cell describing a blueprint for the assembly of these liquid structures, also called condensates. The researchers looked closely at two types of condensates, stress granules and processing bodies (“P-bodies”). In the Cell paper, researchers directed by Clifford Brangwynne, a professor of Chemical and Biological Engineering at Princeton and the Howard Hughes Medical Institute, combined genetic engineering and live cell microscopy approaches to reveal the rules underlying the assembly and structure of stress granules, and why they remain distinct from their close relatives, P-bodies.
Google will add Zoom-like gallery view to Meet and will let Meet users take calls from Gmail
Google plans to add a Zoom-like gallery view to its business- and education-focused Meet videoconferencing service and let users start calls and join meetings right from Gmail, Google’s GM and VP of G Suite Javier Soltero told Reuters in an interview. The additions come amid huge growth for Meet as families, students, and workers use the service while at home due to the COVID-19 pandemic.
The upcoming gallery view will let users display up to 16 meeting participants in one frame, according to Reuters. That functionality is coming later this month, said Soltero. Zoom’s gallery view, by contrast, lets you see the thumbnails of up to 49 people in one screen, if you have a powerful enough CPU to display them all.
In the Future, Human Cloning Might Mean Giving Birth to Your Own Sibling
Human clones have long been a topic of science fiction, but how far off are they in reality? Let’s take a look at current advances and see when and where we might see the first human clone.
New clues to predict the risks astronauts will face from space radiation on long missions
The National Aeronautics and Space Administration, NASA, aims to send human missions to Mars in the 2030s. But scientists are still trying to learn more about the potential cancer risks for astronauts due to radiation exposure. Cancer risk from galactic cosmic radiation exposure is considered a potential “showstopper” for a manned mission to Mars.
A team led by researchers at Colorado State University used a novel approach to test assumptions in a model used by NASA to predict these health risks. The NASA model predicts that astronauts will have more than a three percent risk of dying of cancer from the radiation exposures they will receive on a Mars mission. That level of risk exceeds what is considered acceptable.
The study, “Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and gamma-ray-induced tumors,” was published April 15 in Science Advances.