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The CRISPR/Cas9 gene-editing platform may need a little bit more tweaking before it can be used as an effective antiviral, reports a study published April 7 in Cell Reports. Researchers who used CRISPR/Cas9 to mutate HIV-1 within cellular DNA found that while single mutations can inhibit viral replication, some also led to unexpected resistance. The researchers believe targeting multiple viral DNA regions may be necessary for the potential antiviral aspect of CRISPR/Cas9 to be effective.

Upon entry into a cell, HIV’s RNA genome is converted into DNA and becomes entwined with the cellular DNA. From here, CRISPR/Cas9 can be programmed to target a DNA sequence and cleave viral DNA. The problem is that HIV is notoriously good at surviving and thriving with new mutations, so while many viruses are killed by the targeted approach, those that escape the CRISPR/Cas9 treatment become more difficult to target.

“When we sequence the viral RNA of escaped HIV, the surprise is that the majority of the mutations that the virus has are nicely aligned at the site where Cas9 cleaves the DNA, which immediately indicates that these mutations, instead of resulting from the errors of viral reverse transcriptase, are rather introduced by the cellular non-homologous end joining machinery when repairing the broken DNA,” says senior study author Chen Liang, Senior Investigator at the Lady Davis Institute at the Jewish General Hospital and the Associate Professor of Medicine at the McGill University AIDS Centre.

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Recovering mobility after a stroke or an accident can take a lot of hard work. Now a team in Manchester is using virtual reality to help patients get moving again.

Marge Brown cannot help the tears welling up in her eyes as she watches her husband stroll on a treadmill through a virtual wood he can see on the giant video screen in front of him.

Continue reading “Virtual reality puts patients on the road to recovery” »

One million movies are stored in this vial of water.

30.03.16 — Public Release of Platforms Will Help Advance Collaborative Research in Neuroscience, Medicine, and Computing

The Human Brain Project (HBP) is pleased to announce the release of initial versions of its six Information and Communications Technology (ICT) Platforms to users outside the Project. These Platforms are designed to help the scientific community to accelerate progress in neuroscience, medicine, and computing.

The Platforms released today consist of prototype hardware, software tools, databases and programming interfaces, which will be refined and expanded in a collaborative approach with users, and integrated within the framework of a European Research Infrastructure. The public release of the Platforms represents the end of the Ramp-Up Phase of the HBP and the beginning of the Operational Phase.

Continue reading “Human Brain Project’s Research Platforms Released” »

We would also see a decrease in the hundreds of thousands of arthritis-induced knee and hip replacement surgeries every year.

Stem cells, human trials, regenerative medicine, yay!

Continue reading “A stem-cell repair system that can regenerate any kind of human tissue” »

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Researchers have developed a new and highly efficient method for gene transfer. The technique, which involves culturing and transfecting cells with genetic material on an array of carbon nanotubes, appears to overcome the limitations of other gene editing technologies.

The device, which is described in a study published today in the journal Small, is the product of a collaboration between researchers at the University of Rochester Medical Center (URMC) and the Rochester Institute of Technology (RIT).

Continue reading “‘Honeycomb’ of nanotubes could boost genetic engineering” »

HUGE deal for wearables and biomed technologies.

Researchers from the University of Illinois at Urbana-Champaign have demonstrated a new approach to modifying the light absorption and stretchability of atomically thin two-dimensional (2D) materials by surface topographic engineering using only mechanical strain. The highly flexible system has future potential for wearable technology and integrated biomedical optical sensing technology when combined with flexible light-emitting diodes.

“Increasing graphene’s low light absorption in visible range is an important prerequisite for its broad potential applications in photonics and sensing,” explained SungWoo Nam, an assistant professor of mechanical science and engineering at Illinois. “This is the very first stretchable photodetector based exclusively on graphene with strain-tunable photoresponsivity and wavelength selectivity.”

Continue reading “Crumpling approach enhances photodetectors’ light responsivity” »

What if prospective parents had the opportunity to make decisions ahead of time about the combination of genetic traits their child would inherit? The question is more than science fiction, says Hank Greely, a law professor at Stanford University.

The underlying science and technology are advancing rapidly—and now is the time to consider carefully “what kind of legal changes would be necessary to try to maximize the benefits and minimize the harm of this new approach to making babies,” he says.

Greely explored the legal, ethical, and societal implications of emerging biotechnologies for a new book, The End of Sex and The Future of Human Reproduction (Harvard University Press, 2016), that envisions a world where procreation may not start in bedrooms, but rather in a petri dish in a medical clinic.