The July edition of the Journal Club has us taking a look at a recent paper that casts doubt and concern over the use of CRISPR Cas9 for gene editing.
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The paper we are discussing can be found here: https://www.nature.com/articles/nbt.
These soft robot spiders could change how doctors perform surgery.
For centuries humans have sought the ‘elixir of life’ – a mythical potion that supposedly would grant the drinker eternal life.
Now Exeter scientists believe they may have found the secret to a longer, healthier life.
New compounds developed and tested at the University of Exeter have brought the dream a step closer and paved the way for “anti-degeneration” drugs that could not only extend life, but also extend health and may help treat age-related diseases like cancer, dementia and diabetes.
The compounds — AP39, AP123 and RT01 — have been designed to selectively deliver minute quantities of the gas hydrogen sulphide to the mitochondria in cells and help the old or damaged cells to generate the ‘energy’ needed for survival and to reduce senescence.
In the samples used, the number of senescent cells — older cells that have deteriorated and stopped dividing — was reduced by up to 50 per cent.
The team also identified two splicing factors — a component of cells — that play a key role in when and how endothelial cells become senescent.
New research suggests that a certain kind of ultraviolet light could help in the fight against antibiotic resistant bacteria.
A team of researchers from several institutions in Iceland and the U.S. has conducted a unique blood serum investigation and discovered multiple protein networks that are involved in the aging process. In their paper published in the journal Science, the group describes their study and what they found.
Prior research has shown that when older mice have their blood systems connected to younger mice, the older mice experience improvements in age-related organ deterioration. This finding has led scientists to suspect that aging might be caused by something in the blood. In this new effort, the researchers sought to test this idea by studying proteins in the circulatory system.
The study consisted of analyzing blood samples from 5,457 people living in Iceland, all of whom were over the age of 65 and who were participants in an ongoing study called Age, Gene/Environment Susceptibility. The volunteers had also been chosen specifically to represent a cross section of the people living in Iceland. The major part of the blood analysis involved creating a panel of DNA aptamers (short sequences that bind to proteins) that could be used to recognize proteins, both known and unknown. Blood serum from the volunteers was then compared against the panels and the results were analyzed by a computer looking for patterns.
Roboticists are envisioning a future in which soft, animal-inspired robots can be safely deployed in difficult-to-access environments, such as inside the human body or in spaces that are too dangerous for humans to work, in which rigid robots cannot currently be used. Centimeter-sized soft robots have been created, but thus far it has not been possible to fabricate multifunctional flexible robots that can move and operate at smaller size scales.
A team of researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Boston University now has overcome this challenge by developing an integrated fabrication process that enables the design of soft robots on the millimeter scale with micrometer-scale features. To demonstrate the capabilities of their new technology, they created a robotic soft spider – inspired by the millimeter-sized colorful Australian peacock spider – from a single elastic material with body-shaping, motion, and color features. The study is published in Advanced Materials.
“The smallest soft robotic systems still tend to be very simple, with usually only one degree of freedom, which means that they can only actuate one particular change in shape or type of movement,” said Sheila Russo, Ph.D., co-author of the study. Russo helped initiate the project as a Postdoctoral Fellow in Robert Wood’s group at the Wyss Institute and SEAS and now is Assistant Professor at Boston University. “By developing a new hybrid technology that merges three different fabrication techniques, we created a soft robotic spider made only of silicone rubber with 18 degrees of freedom, encompassing changes in structure, motion, and color, and with tiny features in the micrometer range.”
There is a 3-day conference in Brussels on November 8–10 for those of you in Europe interested in aging research.
The Eurosymposium on Healthy Ageing (EHA) is an international event that provides a unique opportunity for researchers, government officials, biotech executives, entrepreneurs, and non-governmental institutions from around the world to meet, network, and forge new scientific collaborations.