Lifeboat Foundation

Monday May 16th 17:00 GMT 13:00 EST 10:00 PST r/futurology.

The Major Mouse Testing Program is an ambitious project of the International Longevity Alliance, seeking to speed up scientific progress in the field of regenerative medicine and bio-gerontology. After ILA experts conducted an analysis of bottlenecks preventing the development of life extension technologies, it was revealed that one of these bottlenecks is the deficiency of robust animal data for the potential of different compounds to promote health and extend maximum lifespan. Without this data promising interventions cannot enter clinical trials and become available to the general public.

The ILA decided to initiate a fundraising program to fund a series of these high-risk studies: Major Mouse Testing Program. We are currently running a crowdfunding campaign for the first experiment to test a combination of Senolytics. They have been shown to help seek out and destroy senescent “death resistant” cells and improve various aspects of health. We wish to see if Senolytics are able increase maximum lifespan in addition to healthspan promotion. We have big plans for the future with combination testing of senolytics, stem cells and more to help speed up scientific progress. So go ahead ASK US ANYTHING!

Continue reading “The Major Mouse Testing Program AMA on Reddit!” »

The fabrication of a prototype tissue with functional properties close to natural tissues is crucial for effective transplantation. Tissue engineering scaffolds are typically used as supports that allow cells to form tissue-like structures essentially required for the correct functioning of the cells under the conditions close to the three-dimensional tissue.

Scientists of the Bionanotechnology Lab at Kazan Federal University combined biopolymers chitosan and agarose (polysaccharides) and gelatine protein to produce tissue engineering scaffolds and demonstrated the enhancement of mechanical strength, higher water uptake and thermal properties in chitosan-gelatine-agarose hydrogels doped with halloysite.

Chitosan, a natural biodegradable and chemically versatile biopolymer, has been effectively used in antibacterial, antifungal, anti-tumour and immunostimulating formulations. To overcome the disadvantages of pure chitosan scaffolds such as mechanical fragility and low biological resistance, chitosan scaffolds are typically doped with other supporting compounds that allow for mechanical strengthening, thus yielding composite biologically resistant scaffolds.

Continue reading “Clay nanotube-biopolymer composite scaffolds for tissue engineering” »

Very nice.

The Food and Drug Administration has given so-called “breakthrough” status to a treatment that uses the once-feared polio virus to target aggressive forms of brain cancer, in the hope of speeding it to market.

The therapy, developed at Duke University, hopes to use the virus’ debilitating properties to help fight cancer instead of harming its host, CBS News reported Thursday.

Continue reading “FDA fast-tracks treatment that uses polio virus to fight brain cancer” »

Very promising. I hope within the next 10 years that Glioblastoma is eradicated.

A team from the International School for Advanced Studies (SISSA) in Trieste has obtained very promising results by applying gene therapy to glioblastoma. Tests in vitro and in vivo on mice provided very clear-cut results, and modelling demonstrates that the treatment targets at least six different points of tumour metabolism. Gene therapy, a technique that selectively attacks a tumour, might provide hope in the fight against this type of deadly cancer, for which surgery is practically impossible and chemo- and radiotherapy are ineffective against very aggressive recurrences. The study was published in the journal Oncotarget.

Only a few days ago, the press (especially in English-speaking countries) enthusiastically announced the publication of a study that described in great detail the genetics of breast cancer, a discovery that according to many marks a breakthrough in the battle against this cancer. This kind of news confirms the impression that in the near future the war against cancer will be fought on the battlefields of genetics. Italy too, is working on this front. At SISSA, for example, where Antonello Mallamaci and his group have just published highly promising results on the application of gene therapy against glioblastomas, a family of brain tumours among the most common and aggressive. A diagnosis of glioblastoma is literally equal to a very imminent death sentence: “surgery is rarely curative, as these tumours insinuate themselves in healthy tissues, and also chemo- and radiotherapy have little effectiveness.

Singaporean scientists have developed a method for generating stem cells that only requires a single drop of blood.

For my Precision Medicine partners — nice.

Despite eclectic ways of delivering insulin to control blood glucose level in people with type 1 diabetes (T1D), no approach precisely replicates what happens in the body. Gene therapy may hold the answer.

T1D is usually autoimmune, with inherited risk factors such as certain HLA haplotypes contributing to, but not directly causing, the condition. A clever use of gene therapy is to commandeer liver cells to step in for the pancreatic beta cells that autoimmunity destroys.

Continue reading “Gene Therapy for Type 1 Diabetes: Preclinical Promise” »

Imagine this: you accidentally swallowed a battery (!), and to get it out, you need to take a pill that turns into a robot. Researchers from MIT, the University of Sheffield and the Tokyo Institute of Technology have developed a new kind of origami robot that transforms into a microsurgeon inside your stomach. They squished the accordion-like robot made of dried pig intestine inside a pill, which the stomach acid dissolves. A magnet embedded in the middle allows you or a medical practitioner to control the microsurgeon from the outside using another magnet. It also picks up the battery or other objects stuck inside your stomach.

This new design is a follow up to an older origami robot also developed by a team headed by MIT CSAIL director Daniela Rus. It has a completely different design and propels itself by using its corners that can stick to the stomach’s surface. The team decided to focus on battery retrieval, because people swallow 3,500 button batteries in the US alone. While they can be digested normally, they sometimes burn people’s stomach and esophagus linings. This robot can easily fish them out of one’s organs before that happens. Besides origami surgeons, Rus-led teams created a plethora of other cool stuff in the past, including robots that can assemble themselves in the oven.

Continue reading “MIT’s tiny robot operates on your stomach from the inside” »

While CRISPR, nanobots and head transplants are making headlines as medical breakthroughs, a number of new technologies are also making progress tackling some of the toughest age-old diseases still plaguing millions of people in the poorest parts of the world.

In low income countries, over 75% of the population dies before the age of 70 due to infectious diseases including HIV/AIDS, lung infections, tuberculosis, diarrheal diseases, malaria, and increasingly, cardiovascular diseases. Over a third of deaths in low income countries are among children under age 14 primarily due to pneumonia, diarrheal diseases, malaria and neonatal complications. In the developed world, those living in extreme poverty, such as homeless populations, also die on average at age 48.

Over the last year, artificial intelligence, robotics and biotechnology have all generated a number of new solutions that have the potential to dramatically reduce these problems.

Continue reading “Fighting Developing World Disease With AI, Robotics, and Biotech” »

Nice read.

At the beginning of the movie 50/50, Adam Lerner is diagnosed with neurofibrosarcoma, a cancer of the spine’s nerve tissue. Adam sits in his doctor’s office while the doctor rattles off the word several times, but Adam has no idea what it means, or if there’s anything wrong with him at all. Eventually, his doctor uses the word “cancer,” and Adam’s perspective goes blurry, the doctor’s voice drowned out by a high-pitched ringing.

Many people have had real experiences like this one. Cancer is still one of the scariest words you can hear in a diagnosis. And chances are, you know someone who has heard it—almost 40 percent of adults are diagnosed with some form of it during their lifetime. Every patient’s story is different, and they don’t all have a happy ending. But because of decades of research into how cancer works, patients diagnosed with cancer today have a much better chance of survival than ever before.

Continue reading “How The Meaning Of Cancer Has Changed” »