Lifeboat Foundation

Scientists are now one step closer to neutralizing HIV.

In a study conducted at Vanderbilt University and published in Proceedings of the National Academy of Sciences, researchers isolated antibodies with a loop-like structure that binds tightly to HIV and disables it. Unlike traditional vaccines, which jump-start an immune response by exposing the patient to a pathogen, this newly discovered method could work even in people who have not previously been exposed to by the virus.

Using computer modeling, the researchers identified the amino acid sequences that bound most tightly to HIV and re-engineered them in an optimal sequence that simulated vaccination.

Continue reading “Researchers Identify Potential HIV Vaccine Possibility With ‘Looped’ Antibodies” »

DNA used in a thermometer.

A thermometer 20,000-times smaller than a human hair has been developed by researchers using DNA that is capable of measuring temperatures within living cells.

The thermometer, unveiled this week in the journal Nano Letters, was built by scientists at the University of Montreal and is expected to improve human understanding of nanotechnologies.

Continue reading “DNA used to build the world’s smallest thermometer” »

Cool

New York: Scientists have built a “semantic atlas” or a brain map that identifies areas that respond to words having similar meanings. The finding can help give voice to those who cannot speak such as victims of stroke, brain damage or motor neuron diseases.

New keys unlock how words are stored in our brains.

Researchers have created a new map of the human brain which shows where we organize words depending on their meaning—and it could help us read minds more accurately than ever.

Scientists from the University of California, Berkeley, have published an interactive version of the map online. It allows you to explore the whole brain, clicking around to see where different types of words—from social and spatial, to violent and visual—are stored.

Continue reading “New Brain Map Shows Where Words Are Stored Inside Your Head” »

New research by UCSF scientists could accelerate – by 10 to 100-fold – the pace of many efforts to profile gene activity, ranging from basic research into how to build new tissues from stem cells to clinical efforts to detect cancer or auto-immune diseases by profiling single cells in a tiny drop of blood.

The study, published online April 27, 2016, in the journal Cell Systems, rigorously demonstrates how to extract high-quality information about the patterns of gene expression in individual cells without using expensive and time-consuming deep-sequencing technology. The paper’s senior authors are Hana El-Samad, PhD, an associate professor of biochemistry and biophysics at UCSF, and Matt Thomson, PhD, a faculty fellow in UCSF’s Center for Systems and Synthetic Biology.

“We believe the implications are huge because of the fundamental tradeoff between depth of sequencing and throughput, or cost,” said El-Samad. “For example, suddenly, one can think of profiling a whole tumor at the single cell level.”

There’s a precision genetic tool being put to work in crop breeding that offers benefits for future elite, high-performing crops. Pioneer is moving forward with work on a commercial hybrid.

With CRISPR-Cas it’s possible to do precision gene insertions (or deletions) in a crop genome that boost productivity or enhance other traits. This isn’t a GMO because the work done involves traits from the same species — corn gene into a corn plant, for example.

Continue reading “New genetic tools to boost productivity” »

Scientists in Spain say they have created human sperm from skin cells, which could eventually lead to a treatment for infertility.

“[Using DNA,] you could fit all the knowledge in the whole world inside the trunk of your car,” Twist Bioscience CEO Emily Leproust told TechCrunch.

Twist Bioscience, a startup making and using synthetic DNA to store digital data, just struck a contract with Microsoft and the University of Washington to encode vast amounts of information on synthetic genes.

Big data means business and the company able to gather a lot of it is very valuable to investors and stockholders. But that data needs to be stored somewhere and can cost a lot for the upkeep.

Continue reading “Genetics startup Twist Bioscience is working with Microsoft to store the world’s data in DNA” »

Supercomputer facing problems?

In the world of High Performance Computing (HPC), supercomputers represent the peak of capability, with performance measured in petaFLOPs (10¹⁵ operations per second). They play a key role in climate research, drug research, oil and gas exploration, cryptanalysis, and nuclear weapons development. But after decades of steady improvement, changes are coming as old technologies start to run into fundamental problems.

When you’re talking about supercomputers, a good place to start is the TOP500 list. Published twice a year, it ranks the world’s fastest machines based on their performance on the Linpack benchmark, which solves a dense system of linear equations using double precision (64 bit) arithmetic.

Looking down the list, you soon run into some numbers that boggle the mind. The Tianhe-2 (Milky Way-2), a system deployed at the National Supercomputer Center in Guangzho, China, is the number one system as of November 2015, a position it’s held since 2013. Running Linpack, it clocks in at 33.86 × 10¹⁵ floating point operations per second (33.86 PFLOPS).