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Category: biotech/medical – Page 2,622

Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression

The development of new cancer immunotherapies including checkpoint blockade and chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment. CAR T cells have shown tremendous success in certain B cell malignancies, resulting in U.S. Food and Drug Administration (FDA) approval of this approach for certain types of leukemia and lymphoma. However, response rates against solid cancer have been less successful to date. Approaches to modulate the immunosuppressive tumor microenvironment including targeting checkpoint pathways, modulating metabolic pathways, and generating cytokine-producing T cells have led to considerable enhancement of adoptive T cell immunotherapy, first in preclinical models and now in patients.

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David Sinclair – Slowing down Aging (VIDEO)

David A. Sinclair, Ph.D., A.O. is an Australian biologist and a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at the Massachusetts Institute of Technology with Leonard Guarente. Since 1999 he has been a tenured professor in the Genetics Department of Harvard Medical School.

Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media.

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Signs & Symptoms of Bone Marrow Disease

Bone marrow is a soft spongy material that is located inside of the bones. Bone marrow is necessary for the transition that stem cells make to become one of the types of blood cells (red blood cells, platelets or white blood cells). Bone marrow disease occurs when there is some kind of abnormality or interference with the production of blood cells. Leukemia, aplastic anemia and myelodysplastic syndromes (MDS) are three types of bone marrow disorders that affect the production of blood cells and the bone marrow. Symptoms of each type of bone marrow disease will vary according to its severity, but tend to be similar in nature.

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Pfizer had clues its blockbuster drug could prevent Alzheimer’s but kept it secret

Why didn’t it tell the world? Drug companies frequently have been pilloried for not fully disclosing negative side effects of their drugs. What happens when the opposite is the case?

A team of researchers inside Pfizer made a startling find in 2015: The company’s blockbuster rheumatoid arthritis therapy Enbrel, a powerful anti-inflammatory drug, appeared to reduce the risk of Alzheimer’s disease by 64 percent.

The results were from an analysis of hundreds of thousands of insurance claims. Verifying that the drug would actually have that effect in people would require a costly clinical trial — and after several years of internal discussion, Pfizer opted against further investigation and chose not to make the data public, the company confirmed.

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Drugs make headway against lung, breast, prostate cancers

CHICAGO (AP) — Newer drugs are substantially improving the chances of survival for some people with hard-to-treat forms of lung, breast and prostate cancer, doctors reported at the world’s largest cancer conference.

Among those who have benefited is Roszell Mack Jr., who at age 87 is still able to work at a Lexington, Kentucky, horse farm, nine years after being diagnosed with lung cancer that had spread to his bones and lymph nodes.

“I go in every day, I’m the first one there,” said Mack, who helped test Merck’s Keytruda, a therapy that helps the immune system identify and fight cancer. “I’m feeling well and I have a good quality of life.”

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Professor Irena Cosic PhD. — RMIT — Australia — Electromagentic Resonant Recognition Model of Macromolecular Interactions — ideaXme — Ira Pastor

Creating Thymus Organoids Using Tissue Engineering

Today, we wish to highlight a new open access publication in which the researchers take a novel approach to the regeneration of the thymus, a small but vitally important organ that is key to our immune system.

The thymus shrinks as we age

The thymus is one of the most important organs in the body, and it is where thymocytes produced in the bone marrow travel to become new T cells before being trained in the lymph nodes to become the defenders of the adaptive immune system. However, as we get older, the thymus increasingly turns to fat and starts to shrink, causing its ability to produce new T cells to fall dramatically. This process is known as thymic involution and actually begins shortly after puberty, so this is one aspect of aging that begins fairly early in life, although it is many decades later before its decline causes serious health issues.

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‘Iron Man’ actor Robert Downey Jr. has vowed to use robotics and AI to significantly clean up the Earth in the next decade

Robert Downey Jr. doesn’t pretend to be a brilliant scientist — even though he’s played Tony Stark, aka Iron Man, for the past 11 years.

But on Tuesday night he attended Amazon’s brand new, premier, open-to-the-public Machine Learning, Automation, Robotics and Space (re: MARS) conference in Las Vegas — a room filled with AI legends, astronauts, and other dignitaries — as a keynote speaker.

He delivered a gag-filled talk that somehow weaved together the history of the Marvel Cinematic Universe, the evolution of Stark’s Iron Man suits, allusions to his own troubled history with drug addiction, the actual history of artificial intelligence and its pioneers, with a bunch of jokes using the Amazon Alexa voice and Matt Damon (including a videotaped guest appearance by Damon).

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