Lifeboat Foundation

Washington D.C.: A new study has revealed that fruit flies, who have similar sleeping habits like humans, can tell a lot about the connection between sleep deprivation and metabolic disorders like diabetes, obesity, and blood glucose levels.

The study conducted by the Florida Atlantic University is the first to identify that a conserved gene called translin works as a modulator of sleep in response to metabolic changes.

The study establishes that translin is an essential integrator of sleep and metabolic state, with important implications for understanding the neural mechanism underlying sleep deprivation in response to environmental challenges.

Continue reading “Gene responsible for sleep deprivation discovered” »

The toughest thing about HIV is the fact that it can mutate and hide and pretend to be a healthy cell. This is what makes it hard to cure HIV or AIDS. However there has been progress in Temple University as their researchers were able to find a way to eradicate HIV-1 from the body through gene-snipping.

FRIDAY, March 25, 2016 — Brain stimulation may ease major symptoms of the eating disorder anorexia nervosa, a typically hard-to-treat condition, a new study suggests.

British researchers evaluated anorexia patients before and after they underwent repetitive transcranial stimulation (rTMS), a treatment approved for depression.

“With rTMS we targeted … an area of the brain thought to be involved in some of the self-regulation difficulties associated with anorexia,” study first author Jessica McClelland, a postdoctoral researcher at King’s College London, said in a school news release.

Continue reading “Brain stimulation may help people with anorexia” »

When Jacob Barnes was 12, he mysteriously stopped growing. He watched as his friends began swapping out kid’s clothes for the men’s section and shaving in high school, but while they went through puberty, he just “stayed the same.”

“My family doctor was like ‘Jacob, something’s wrong, you look like you are 12, and you’re 16,’” he said.

In 2012, Barnes, who grew up an hour outside of Cleveland, was 17 and only 5-foot-2. He looked like he was in middle school, yet he was two years away from high school graduation.

Continue reading “Man’s unusual tumor halted his growth during teen years” »

WIKIMEDIA, ROBINSON RCRISPR-a bacterial immune response best known for its genome-editing applications in the lab-has yet again been adapted for scientific purposes, this time to track RNA within cells. Considering the case of synapses — the proteins required for these neural connections are produced from RNAs located at these contacts.

“Just as CRISPR-Cas9 is making genetic engineering accessible to any scientist with access to basic equipment, RNA-targeted Cas9 may support countless other efforts for studying the role of RNA processing in disease or for identifying drugs that reverse defects in RNA processing”, study coauthor David Nelles of the University of California, San Diego, said in a press release. Defective RNA transport is linked to a host of conditions ranging from autism to cancer and researchers need ways to measure RNA movement in order to develop treatments for these conditions. “Our current work focuses on tracking the movement of RNA inside the cell, but future developments could enable researchers to measure other RNA features or advance therapeutic approaches to correct disease-causing RNA behaviors”. But, Gene Yeo, Associate Professor of Cellular and Molecular Medicine at UC San Diego, and his team have applied the technique as a flexible means to targeting RNA in live cells.

Jennifer Doudna, the creator of the CRISPR-Cas9 system for DNA editing, also works out of the University of California research system, and is listed as a co-author for this study. A guide RNA, along with the addition of an oligonucleotide sequence, sent the Cas9 RNA-ward.

Continue reading “CRISPR Used to Target RNA in Live Cells For the First Time” »

Last summer, the team reported another achievement: the development of a DNA nanosensor that can measure the physiological concentration of chloride with a high degree of accuracy.

“Yamuna Krishnan is one of the leading practitioners of biologically oriented DNA nanotechnology,” said Nadrian Seeman, the father of the field and the Margaret and Herman Sokol Professor of Chemistry at New York University. “These types of intracellular sensors are unique to my knowledge, and represent a major advance for the field of DNA nanotechnology.”

Chloride sensor

Continue reading “DNA Devices Perform Bio-Analytical Chemistry Inside Live Cells” »

One of the things I love most about being a Surgical Oncologist is that I see my patients for years after I have treated them. However, my clinic days are inevitably like the opening scenes from the old Wide World of Sports television program that aired on Saturday afternoons on ABC. I remember watching this show on weekends as a child and teenager. The “thrill of victory”, with images of athletes crossing the finish line in first place, equates to those patients who receive good news during their clinic visit. I tell them I am confident I can perform an operation to remove their cancer; or I confirm that their blood tests and scans show that tumors have not recurred after surgery, chemotherapy, and other treatments; or we pass some major chronologic milestone without evidence of cancer rearing its ugly head again (many patients still believe the 5 year anniversary of being cancer-free equates with being “cured”, if only that were always true). In contrast, the “agony of defeat”, forever seared in my memory in the opening scenes of Wide World of Sports with the ski jumper falling off the end of the jump and bouncing hard off the slope, represents the distress and depression felt by patients and their family members when I deliver bad news.

I would never make it as a professional poker player because I can’t bluff when I’m holding a bad hand or keep from grinning when I have a good one. My patients can tell from my face when I walk into the clinic room what the news is going to be. When all of the blood tests and scans reveal no evidence of cancer recurrence, I walk in smiling and immediately tell all gathered in the room that everything looks great and I see no evidence of any cancer. The remainder of the visit becomes a combination of medical checkup and social enterprise. I inquire about the well-being of their children, grandchildren, parents, other friends and relatives I have met, their pets, their gardening, their recent travels, and sundry snippets of their ongoing lives. Patients frequently bring pictures of children and grandchildren, or travel photos of places they have been since their last visit with me. Often I’m asked for medical advice on conditions totally unrelated to their cancers as they get farther and farther away from that diagnosis. My patients also know about tidbits from my life. They ask about the status of soccer teams that I coached, how my son or daughter were doing in college (both graduated and onto successful careers, thank you), and whether I have progressed from owning a Ferrari lanyard to hold and display my medical badge (I’m a fan of Ferrari F1 racing) to actually owning a Ferrari automobile (I do not).

I am told by patients, family members, and members of my patient care team that I am quite solemn when I walk in a clinic room to deliver bad news. No “light-hearted” chatter or discussion of recent family events or outings occurs. The nervous, hopeful smiles on the faces of the patient and the family members in the room quickly fade as I describe what I am seeing on their blood tests and the scans I have reviewed. Friedrich Nietzsche, the pejorative poster boy of pessimism, is credited with the aphorism, “Hope is the worst of evils, for it prolongs the torments of man.” Thankfully, he was not involved in the care of patients with cancer or other chronic illnesses. A particular patient comes to mind when I remember the importance of dealing with both the highs and the lows of talking with cancer patients.

The patient in question was the wife of an Emeritus Professor of Engineering at a prestigious American university. The Professor knew a thing or two about scientific investigation, statistics, and assessments of probability. Mrs. Professor had a large, grapefruit-sized malignant vascular tumor in the center of her liver called an epithelioid hemangioendothelioma. Quite a mouthful of a name for a rare malignant tumor of the liver. Her tumor was in an unfortunate location in the center of the liver and was wrapped around two of the three veins that drain all of the blood out of the liver into a large blood vessel called the inferior vena cava. The tumor was abutting a portion of the third vein. As a hepatobiliary surgical oncologist, I know I must preserve at least one of these veins to allow blood that flows into the liver to flow back out properly. She had seen surgeons at several other hospitals in the United States and was told that the tumor was inoperable and untreatable. If she was lucky, she might live a year, these doctors told my patient and her husband. The Professor contacted me, and I examined Mrs. Professor and evaluated her prior scans, and then obtained some additional high resolution scans to better understand the appearance of her tumor. I realized that her particular tumor had a very thick fibrous capsule surrounding it. I explained to the patient and her husband that it may be possible to remove the tumor, but that it would be challenging. This lady who had been sullen, withdrawn, and tearful every time I had met with them previously suddenly looked up and said, “If there’s any chance, I’m willing to take it!” I preceded the next week to perform an operation that removed the entire left lobe and a portion of the right lobe of her liver and I was able to gently dissect the tumor capsule free from the third hepatic vein. The operation was successful and the patient recovered well over the next several weeks.

Continue reading “Good News Bad News” »

Genomic pioneer Craig Venter has created a cell with the smallest possible number of genes needed to survive.

Knee problems? No problem.