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Category: biotech/medical – Page 2,624

Depression, obesity, chronic pain could be treated by targeting the same key protein

Major depression, obesity and chronic pain are all linked to the effects of one protein, called “FK506-binding protein 51,” or FKBP51. Until now, efforts to inhibit this target have been hampered by the difficulty of finding something specific enough to do the job and not affect similar proteins. Now a research group has developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. The new compound also could have applications in alcoholism and brain cancer.


‘Jumping genes’ drive many cancers

Wang and his colleagues found that many cancers that get switched into overdrive and boost tumor growth have jumping genes that function as a kind of stealthy “on switch.” These cryptic switches can force a gene to be turned on all the time, even though it should be off.

Mistakes in DNA are known to drive cancer growth. But a new study, from Washington University School of Medicine in St. Louis, heavily implicates a genetic phenomenon commonly known as “jumping genes” in the growth of tumors.

The study is published March 29 in the journal Nature Genetics.

Since jumping genes aren’t mutations—mistakes in the letters of the DNA sequence—they can’t be identified by traditional cancer genome sequencing. As such, this study opens up new lines of research for future cancer therapies that might target such genes.

After 3 days packed with exciting talks on how to bring aging under full medical control, over 40 awesome speakers, lots of positive and extremely motivating energy, an amazing Undoing Aging 2019 ended with a big party!

After being sold out this year with nearly 500 participants, we will be back in 2020!

Already missing us? Subscribe to the Undoing Aging YouTube channel to get notified when the UA2019 speaker presentations are released: youtube.com/c/UndoingAging

This company wants to deliver a baby in space and prepare humanity for a life beyond Earth

What happens when Earth’s resources run out? Well, if science fiction has taught us anything, it’s that humanity will seek a new and habitable planet somewhere in the cosmos on which to keep the species going in perpetuity. When that day comes, we’ll need a viable way to procreate and deliver children in the vastness of outer space.

Enter SpaceLife Origin, a one-of-a-kind tech company that is seeking to make it possible for humans to give birth in the vacuum of space by 2024, a goal titled “Mission Cradle.” While that is its ultimate goal, SpaceLife is also striving to become the first company to “safe-guard human ‘Seeds-of-Life’ in space [Mission Ark] by 2020 [and] make embryo conception in space feasible [Mission Lotus] by 2021,” according to its official website.

The gallery below offers a glimpse at the patent-pending “Ark” designs. Vials of human DNA will be protected within the radiation-shielded spheres that are to be kept on Earth and satellites surrounding the planet. SpaceLife Origin describes this as an insurance policy for the continuation of mankind in case a catastrophe hits and we need to leave in a hurry.

Supercomputers help supercharge protein assembly

Red blood cells are amazing. They pick up oxygen from our lungs and carry it all over our body to keep us alive. The hemoglobin molecule in red blood cells transports oxygen by changing its shape in an all-or-nothing fashion. Four copies of the same protein in hemoglobin open and close like flower petals, structurally coupled to respond to each other. Using supercomputers, scientists are just starting to design proteins that self-assemble to combine and resemble life-giving molecules like hemoglobin. The scientists say their methods could be applied to useful technologies such as pharmaceutical targeting, artificial energy harvesting, ‘smart’ sensing and building materials, and more.

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