Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 2,641

Global quadrupling of cooling appliances to 14 billion by 2050

Soaring global need for cooling by 2050 could see world energy consumption for cooling increase five times as the number of cooling appliances quadruples to 14 billion—according to a new report by the University of Birmingham, UK.

This new sets out to provide, for the first time, an indication of the scale of the implications of ‘Cooling for All’.

Effective is essential to preserve food and medicine. It underpins industry and economic growth, is key to sustainable urbanisation as well as providing a ladder out of rural poverty. With significant areas of the world projected to experience temperature rises that place them beyond those which humans can survive, cooling will increasingly make much of the world bearable—or even safe—to live in. With populations increasing, expanding urbanisation and impacts leading to more frequent heatwaves and temperature rises, the demand for more cooling will increase in the decades ahead.

Two Papers Trace The Steps Leading From Moles to Melanomas

Researchers isolated several mutations leading to melanoma and reproduced them in the lab using CRISPR.

Two papers authored by researchers at the University of California, San Francisco described the genetic changes that turn harmless moles into malignant melanomas and the experiment they devised to recreate the step-by-step evolution of normal skin cells into cancer cells [1], [2].

Summary ([1])

We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically distinct areas of melanocytic neoplasia from 82 patients. Somatic alterations sequentially induced mitogen-activated protein kinase (MAPK) pathway activation, upregulation of telomerase, modulation of the chromatin landscape, G1/S checkpoint override, ramp-up of MAPK signaling, disruption of the p53 pathway, and activation of the PI3K pathway; no mutations were specifically associated with metastatic progression, as these pathways were perturbed during the evolution of primary melanomas. UV radiation-induced point mutations steadily increased until melanoma invasion, at which point copy-number alterations also became prevalent.

The Forever Healthy Foundation Fellowship in Rejuvenation Biotechnology

Do you want to join in the fight to end age-related disease?

Request for Proposals (RFP)

In cooperation with the Forever Healthy Foundation, SENS Research Foundation (SRF) is inviting candidates to submit research proposals for a Fellowship in Rejuvenation Biotechnology that would be undertaken at our Research Center (RC) in Mountain View, California.

SRF pursues the development of therapies to prevent and reverse age-related disease and disability through a “damage-repair” paradigm: developing interventions that maintain and restore the structural and functional integrity of tissues by directly removing, repairing, replacing, or rendering harmless the cellular and molecular damage of aging. Applications are requested that promise progress in regenerative medicine for the prevention and reversal of age-related disease.

Magnetic Microrobots Deliver Cells Into Living Animals

Researchers used magnetically driven microrobots to carry cells to predetermined spots within living zebrafish and mice, they report in Science Robotics today (June 27). The authors propose using these hair-width gadgets as delivery vehicles in regenerative medicine and cell therapy.

The scientists used a computer model to work out the ideal dimensions for a microrobot; spiky, porous, spherical ones were deemed best for transporting living cells. They printed the devices using a 3D laser printer and coated the bots with nickel and titanium to make them magnetic and biocompatible, respectively. An external magnetic field applied to the animal then leads the microrobots.

To begin with, the research team tested the ability for the robots to transport cells through cell cultures, blood vessel–like microfluidic chips, and in vivo in zebrafish. Further, they used these microrobots to induce cancer at a specific location within mice by ferrying tumor cells to the spot. The team observed fluorescence at the target site as the labeled cancer cells proliferated.

This drone can fly dangerous missions for the military in areas where helicopters can’t reach

Tactical Robotics’ Cormorant drone design allows it to navigate tight areas where a helicopter’s blades would get caught on the environment. The remote-controlled military drone can transport two injured people from a battle zone. The Israeli-based company believes the drone could one day also be used to inspect bridges, deliver medical supplies and spray crops.

Do You Trust This Computer

Elon Musk Wants You to Watch ‘Do You Trust This Computer?’ in Memory of Stephen Hawking, and It’s Free.

Because “nothing will affect the future of humanity more than digital super-intelligence,” Elon Musk thinks you should watch Chris Paine’s artificial-intelligence movie “Do You Trust This Computer?” And, wouldn’t you know it, the film is streaming for free until later tonight.

Here’s the synopsis: “Science fiction has long anticipated the rise of machine intelligence. Today, a new generation of self-learning computers has begun to reshape every aspect of our lives. Incomprehensible amounts of data are being created, interpreted, and fed back to us in a tsunami of apps, personal assistants, smart devices, and targeted advertisements. Virtually every industry on earth is experiencing this transformation, from job automation to medical diagnostics, even military operations. ‘Do You Trust This Computer?’ explores the promises and perils of our new era. Will A.I. usher in an age of unprecedented potential, or prove to be our final invention?”

Nothing will affect the future of humanity more than digital super-intelligence. Watch Chris Paine’s new AI movie for free until Sunday night at http://doyoutrustthiscomputer.org/watch

[email protected]
Telegram Group: https://telegram.me/mcgregorrecruitme…
Telegram Channel: https://telegram.me/vacanciesinuae
LinkedIn Group: https://www.linkedin.com/groups/12102…

New drug shows promise for preventing and even reversing damage from age-related dementia and stroke

Cerebral small vessel disease (SVD) is one of the most commonly associated causes of age-related dementia and stroke. New research, led by the University of Edinburgh, may have finally uncovered the mechanism by which SVD causes brain cell damage, as well as a potential treatment to prevent the damage, and possibly even reverse it.

SVD is thought to be responsible for up to 45 percent of dementia cases, and the vast majority of senior citizens are suspected of displaying some sign of the condition. One study strikingly found up to 95 percent of subjects between the ages of 60 and 90 displayed some sign of SVD when examined through MRI scans.

The new research set out to examine early pathological features of SVD and found that dysfunction in endothelial cells are some of the first signs of the disease’s degenerative progression. These are cells that line small blood vessels in the brain and, in early stages of SVD, they secrete a protein that impairs production of myelin, a compound essential for the protection of brain cells.