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Category: biotech/medical – Page 2,641

Nanoparticle chomps away plaques that cause heart attacks

Michigan State University and Stanford University scientists have invented a nanoparticle that eats away—from the inside out—portions of plaques that cause heart attacks.

Bryan Smith, associate professor of biomedical engineering at MSU, and a team of scientists created a “Trojan Horse” nanoparticle that can be directed to eat debris, reducing and stabilizing plaque. The discovery could be a potential treatment for atherosclerosis, a leading cause of death in the United States.

The results, published in the current issue of Nature Nanotechnology, showcases the nanoparticle that homes in on due to its high selectivity to a particular immune cell type—monocytes and macrophages. Once inside the macrophages in those plaques, it delivers a drug agent that stimulates the cell to engulf and eat cellular debris. Basically, it removes the diseased/dead in the plaque core. By reinvigorating the macrophages, size is reduced and stabilized.

Brian Kennedy Joins the LEAF Scientific Advisory Board

We are delighted to announce that Dr. Brian Kennedy, a Distinguished Professor in the Department of Biochemistry and Physiology at the National University of Singapore (NUS) will be joining the LEAF scientific advisory board.

Professor Kennedy is an important figure in the research community, as he is internationally recognized for his research and efforts to translate those findings into therapies that could potentially slow, delay, or even prevent age-related diseases. He previously served as the President of the Buck Institute, where he still remains as a Professor.

At the NUS, he is developing therapeutic interventions that directly target human aging along with biomarkers that can validate if a therapy has worked or not. Professor Kennedy and his team have been exploring the epigenetic clock, a biomarker that measures methylation of the human genome to determine biological age. They are also investigating inflammatory biomarkers of aging using metabolomics, the study of chemical processes involving metabolites, the intermediates and products of metabolism.

World’s First Completely Robotic Heart

The world’s first completely robotic heart may end the need for transplants from dead humans in as few as 10 years, the hybrid heart made of soft artificial muscles and sensors is hoped to eventually end the need for human transplants.

The hybrid robotic heart is under development and could clear NHS heart transplant waiting lists and save many lives. It is the first hybrid heart made from soft artificial muscles and sensors which are coated in human tissues that are grown in a laboratory.

There are plans partnered with the British Heart Foundation to transplant it into the first person in 2028; the hope is that this hybrid robotic heart will save thousands of lives who would normally have died while waiting for a human organ donor on global waiting lists.

Scientists Build “First Living Robots” From Frog Stem Cells

A team of researchers have built what they claim to be the first living robots. The “xenobots,” they say, can move, pick up objects, and even heal themselves after being cut.

The team is hoping the biological machines could one day be used to clean up microplastics in the ocean or even deliver drugs inside the human body, The Guardian reports.

To build the robots, the team used living cells from frog embryos and assembled them into primitive beings.

KQ passenger from Guangzhou quarantined over fears of coronavirus

A Kenya Airways passenger who arrived from Guangzhou with flu-like symptoms has been quarantined at the Kenyatta National Hospital (KNH) over fears of the coronavirus.

A statement from Kenya Airways confirmed that the Kenyan passenger had travelled to Nairobi from Guangzhou on Tuesday.

“Decision to quarantine the passenger was reached by the Kenya Government port health authorities stationed at JKIA,” the statement reads.

Clock and TMRCA based on 27 genomes

Estimates of the clock and TMRCA for 2019-nCoV based on 27 genomes.

Kristian Andersen, Scripps Research

[email protected]

Following up on the analyses provided by Andrew Rambaut this is a brief report estimating the evolutionary rate and timing of the epidemic (date of the most recent ancestor (MRCA)) based on 27 publicly shared n2019-nCoV genome sequences. Compared to earlier analyses where several parameters had to be fixed, there is now enough information content in the sequences to obtain reasonable estimates of the clock and TMRCA without fixing parameters. This work is for information purposes only and is not intended for publication. All the data used here is provided by the laboratories listed below through NCBI Genbank or GISAID.

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