Lifeboat Foundation

Could the FDA crush IoT opportunities in Healthcare?

The U.S. Food and Drug Administration last week took a step toward addressing the threat the Internet of Things poses to patients and their data by releasing some proposed guidelines for managing cybersecurity in medical devices.

“A growing number of medical devices are designed to be networked to facilitate patient care. Networked medical devices, like other networked computer systems, incorporate software that may be vulnerable to cybersecurity threats,” the FDA says in its proposal.

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An experiment by University of Washington researchers is setting the stage for advances in mind reading technology. Using brain implants and sophisticated software, researchers can now predict what their subjects are seeing with startling speed and accuracy.

The ability to view a two-dimensional image on a page or computer screen, and then transform that image into something our minds can immediately recognize, is a neurological process that remains mysterious to scientists. To learn more about how our brains perform this task—and to see if computers can collect and predict what a person is seeing in real time—a research team led by University of Washington neuroscientist Rajesh Rao and neurosurgeon Jeff Ojermann demonstrated that it’s possible to decode human brain signals at nearly the speed of perception. The details of their work can be found in a new paper in PLOS Computational Biology.

The team sought the assistance of seven patients undergoing treatment for epilepsy. Medications weren’t helping alleviate their seizures, so these patients were given temporary brain implants, and electrodes were used to pinpoint the focal points of their seizures. The UW researchers saw this as an opportunity to perform their experiment. “They were going to get the electrodes no matter what,” noted Ojermann in a UW NewsBeat article. “We were just giving them additional tasks to do during their hospital stay while they are otherwise just waiting around.”

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Researchers have successfully demonstrated how it is possible to interface graphene — a two-dimensional form of carbon — with neurons, or nerve cells, while maintaining the integrity of these vital cells. The work may be used to build graphene-based electrodes that can safely be implanted in the brain, offering promise for the restoration of sensory functions for amputee or paralysed patients, or for individuals with motor disorders such as epilepsy or Parkinson’s disease.

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The burgeoning field of nanotechnology promises an indefinite range of capabilities in medicine, optics, communications, and other facets of applied science and engineering. On that front, the U.S. Defense Advanced Research Projects Agency’s (DARPA) Atoms 2 Products program (A2P) is funding 10 companies, universities, and institutions to develop mass-manufacturing techniques and technologies for functional products made up of nanoscale constituents. The project demonstrates a mere slice of the contributions in the mass movement to make nanotechnology a part of our everyday lives.

The following gallery highlights the work of five DARPA-funded projects in the program. The slides describe an atomic calligraphy technique for 2D atomic printing, a manufacturing method for producing high-frequency “Nanolitz” wires, the construction of pop-up sensors for laparoscopy, and a conjunct effort to use micro-robotics to build the assemblers of nanodevices.

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59% of the providers surveyed recently state that they have no intentions of offering precision treatment such as CRISPR for the next 5 yrs. which means patients with MS, Dystonia, Cancer, etc. will not necessarily get proper choice of treatments that they deserve.

As the Obama administration looks to Congress to fund its $215 million Precision Medicine Initiative, a new poll of healthcare executives indicates that most hospitals and health systems are not planning on leveraging such advances in genomics and data analytics to personalize patient care.

In the poll, conducted by analytics vendor Health Catalyst, 59 percent of respondents indicated that precision medicine will not play a significant role in their organizations over the next five years.

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Over the last 12,000 years or so, human civilization has noticeably reshaped the Earth’s surface. But changes on our own planet will likely pale in comparison when humans settle on other celestial bodies. While many of the changes on Earth over the centuries have been related to food production, by way of agriculture, changes on other worlds will result, not only from the need for on-site production of food, but also for all other consumables, including air.

As vital as synthetic biology will be to the early piloted missions to Mars and voyages of exploration, it will become indispensable to establish a long-term human presence off-Earth, namely colonization. That’s because we’ve evolved over billions of years to thrive specifically in the environments provides by our home planet.

Our physiology is well-suited to Earth’s gravity and its oxygen-rich atmosphere. We also depend on Earth’s magnetic field to shield us from intense space radiation in the form of charged particles. In comparison, Mars currently has no magnetic field to trap particle radiation and an atmosphere that is so thin that any shielding against other types of space radiation is negligible compared with the protection that Earth’s atmosphere affords. At the Martian surface, atmospheric pressure never gets above 7 millibars. That’s like Earth at an altitude of about 27,000 m (89,000 ft), which is almost the edge of space. And it’s not like the moon is a better option for us since it has no atmosphere at all.

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Healthcare has a new set of hospital cleaners through Maidbot.

Maidbot, an Ithaca-based startup run by Cornell students that combines hospitality and robotics, has gained attention in several competitions around the country, most recently competing against 14 other college startups in the RECESS Pitch Competition earlier this month. “With this new automated system we were really excited to revolutionize and transform the hospitality industry.” —Micah Green ’18.

Additionally, Maidbot was announced as one of 32 semi-finalists in the Student Startup Madness competition — a collegiate startup tournament at SXSW — earlier this month. If Maidbot is to win in the semi-final round, the startup will be able to pitch to investors in Austin, Texas, in March. Inspired by the television show The Jetsons, Maidbot is a robot created to assist hotel room attendants with housekeeping tasks. Micah Green ’18, a co-founder of the company, had previously worked as a room attendant at a hotel.

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Could we actually start seeing some standards around CRISPR being proposed & implemented around CRISPR?

Bethesda, MD –This SRC will present the very latest developments in this field, with talks by leading international experts working with both prokaryotic and eukaryotic models. This unique blend from the two communities is always much appreciated by attendees of this meeting and one of its main highlights. The topics covered will include events occurring at both the 5’ and 3’ ends of mRNA related to decay, the links between translation, quality control and mRNA stability, and the relationship between RNA degradation and disease. Two full sessions will be devoted to mechanisms of sRNA, CRISPR RNA and miRNA regulation and how they pertain to mRNA stability. The meeting is traditionally of a very manageable size (typically about 120 attendees), providing unrestricted access to students and post-docs for dynamic discussions with more established scientists and potential future employers. Informal Meet the Expert sessions will be held over lunch, with assigned tables to selected speakers.

There will be a total of 9 very broad-ranging sessions over the 4 days, with 36 invited speakers at the top of their fields and two internationally renowned keynote speakers, Chris Lima and Jörg Vogel. Speakers are encouraged to present their most recent and unpublished data. There will be two poster sessions and 2–3 additional speakers per session will be chosen to give oral presentations, based on the submitted abstracts. This promises to be a very interesting and lively meeting in one of Europe’s most beautiful cities. We hope to see you there!

Continue reading “Post-transcriptional control of gene expression: mRNA decay” »

Now, this is intriguing — pathways are a critical part of our system that monitors and manages how our bodies respond and interact to changes in our bodies. This recent SRC report focuses on the researchers efforts in monitoring pathways and how defects in pathways contribute to the biology and pathophysiology of cancer.

Bethesda, MD — This SRC focuses on new developments in the biology of lipid signaling with an emphasis on cancer, neuronal and cardiovascular diseases. The emphasis will be on molecular, cellular, structure/function and enzymatic mechanisms of physiological signaling pathways and how defects in these pathways contribute to the biology and pathophysiology of cancer, neurodegeneration and cardiovascular disease. The focus will be on how diacylglycerol, phosphatidic acid, lysophospholipids, sphingolipids and phosphoinositide lipids modulate specific pathways and processes in the contexts of physiological growth-regulatory signals, intracellular and extracellular vesicular trafficking, regulation of cell polarization, migration, motility and invasion, autophagy and epithelial extrusion, and as nuclear regulators of mRNA processing and gene expression. These sessions will include discussions on how signaling becomes dysfunctional in diseases. There will be presentations on new translational approaches and therapeutic targets. There will be significant representation from the pharmaceutical and biotechnology industry in order to facilitate networking between industry and academia. The topic areas have been chosen to maximize discussion of provocative and important developments.

We particularly wish to encourage the participation of new and junior researchers in the field and are securing additional support to provide PhD/postdoctoral fellow travel awards. Organizers have kept multiple short session speaking slots open. These will be selected from novel advances during 2015–2016 and from submitted abstracts. There will be multiple opportunities for new investigators and postdoctoral fellows to present and discuss their work including at poster sessions, short talks and short 5–10 minute oral ‘research snapshots’ to highlight their submitted abstracts. There will be multiple poster sessions during the conference. Time will also be allocated to at least two “meet the expert sessions” wherein established research leaders will dedicate time to interact with trainees and new investigators, specifically to give advice concerning the science and possible prospects for postdoctoral training, research funding, publishing or employment tracks.

Continue reading “Phospholipid signaling in cancer, neurodegeneration and cardiovascular disease” »