Lifeboat Foundation

Might we one day have bionic body parts able to ward off disease and injury and even heal themselves? Today it’s still the stuff of sci-fi movies, but there are regular breakthroughs in the field of medical science that suggest that such a future might one day be possible – one example is a new nanoshell treatment from a team working at the University of Michigan in the US and reported in Gizmag.

Instead of using foreign cells or molecules to patch up and regrow damaged bone tissue, the new technique uses polymer nanoshells – microscopic capsules inside the body – to deliver microRNA molecules right to the site of an injury. Once the shells begin to break down, the microRNA molecules are released and instruct the surrounding cells to ‘switch on’ their natural bone-building and healing mechanisms. It’s a bit like a site manager arriving on the scene of a broken-down development and telling his construction workers to get busy with the rebuilding process.

There are a couple of key advantages to this new technique. One, the shell is designed to degrade slowly, leading to a gradual release of the microRNA molecules and thus ongoing restorative treatment that can last for a month or more. Second, the process uses the body’s own cells rather than introducing foreign healing agents – an approach that can sometimes cause cell rejection or even tumours associated with the injury.

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Imagine: What happens when you’re in 2027 on the job competing with other AI; and there is so much information exposed to you that you’re unable to scan & capture all of it onto your various devices and personal robot. And, the non-intrusive nanobot for brain enhancement is still years away. Do you finally take a few hundred dollars & get the latest chip implant requiring a tricky surgery for your brain or wait for the nanobot? These are questions that folks will have to assess for themselves; and this could actually streamline/ condition society into a singularity culture. https://lnkd.in/bTVAjhb

A mom pushes a stroller down the sidewalk while Skyping. A family of four sits at the dinner table plugged into their cell phones with the TV blaring in the background. You get through two pages in a book before picking up your laptop and scrolling through a bottomless stream of new content.

Information technology has created a hyper-connected, over-stimulated, distracted and alienated world. We’ve been living long enough with internet-connected computers and other mobile devices to have begun to take it for granted.

Continue reading “Why Digital Overload Is Now Central to the Human Condition” »

Allows for more easily building tiny machines, biomedical sensors, optical computers, solar panels, and other devices — no complex clean room required; portable version planned.

Illustration of the bubble-pen pattern-writing process using an optically controlled microbubble on a plasmonic substrate. The small blue spheres are colloidal nanoparticles. (credit: Linhan Lin et al./Nano Letters)

Continue reading “‘Bubble pen’ can precisely write patterns with nanoparticles as small as 1 nanometer” »

Excellent news; Intellia to continue their focus of leveraging the CRISPR/Cas9 across a variety of immune cells, such as natural killer cells and T-cells. From my own experiences with T-cells and other blood disorders; this is a big deal and one that I personally excited to see what potential cures and improvements come about.

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Intellia Therapeutics, a leading gene-editing company, has launched a new division, eXtellia Therapeutics, with the intent of focusing resources and research on ex vivo applications of the novel technology, CRISPR/Cas9. As in vivo and ex vivo programs require different competencies in research, manufacturing and commercialization, eXtellia Therapeutics is being launched to accelerate Intellia’s efforts in areas of significant unmet medical need – immuno-oncology, autoimmune and inflammatory diseases – using an ex vivo approach. Intellia will continue its in vivo programs and strategy through a dedicated scientific team.

“We are excited to announce the establishment of eXtellia, increasing our footprint in ex vivo gene editing for oncology and autoimmune diseases,” said Nessan Bermingham, Ph.D., Chief Executive Officer and Founder, Intellia Therapeutics. “eXtellia enables us to bring together the required capabilities needed to take the CRISPR/Cas9 technology beyond Intellia’s emerging in vivo, HSC and CAR-T efforts. We believe eXtellia further positions us to maximize the CRISPR/ Cas9 opportunity to address severe unmet medical needs for patients.”

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This is excellent news for Epilepsy.

Epilepsy, a disorder in which nerve cell activity in the brain is disturbed, causing seizures, is the fourth most common neurological problem, following only migraine, stroke and Alzheimer’s. There is no cure for epilepsy, but there are a variety of treatment options. The disease is estimated to affect 2.2 million people in the U.S., with 150,000 people developing the condition each year.

Personalized medicine Scientists at AES discussed how new technologies, such as gene editing using CRISPR-Cas9, and next-generation sequencing, are empowering them to take a new crack at the human genome and find new ways to diagnose and treat epilepsy.

Continue reading “Genomics, Cannabidiols Drive Epilepsy Research” »

Tardigrades, or “water bears,” are renowned for their remarkable survival skills. But these microscopic creatures are far more indestructible than we thought. In a recent experiment, scientists in Japan successfully revived a tardigrade that had been frozen for more than three decades.

That’s a new record.

Tardigrades are tiny water-dwelling extremophiles that are capable of withstanding some of the most severe environmental conditions, including freezing, total dehydration, radiation, and even the vacuum of space. Much of this has to do with their extraordinary genome, of which nearly 18% is comprised of DNA from other organisms, including plants, fungi, bacteria, and viruses.

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Scientists have developed motorised ‘spermbots’ by attaching tiny metal helices to sperm cells that can aid poor swimmers to reach an egg, an advance that could improve fertility treatments.

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Was hit by a car when I was younger and broke my leg. This would have been better then a metal rod. Fascinating.

A team of researchers from the University of Michigan has developed a new technique to aid bone repair, using polymer nano-shells to deliver microRNA molecules. The method could one day have a big impact on regenerative medicine, directing cells already present at injury sites to aid healing.

The new study builds on previous research conducted back in 2011, where nanofiber microspheres were used to carry cells to injury sites to help the wounding process. The new work uses the same idea, but rather than transporting foreign cells, focuses on making better use of the cells already at the wound site.

Continue reading “Scientists use polymer nano-shell treatment to order bones to repair themselves” »

I was shocked to learn recently that one of the major reasons longevity drugs haven’t been going to human trials, despite obvious promise, is that the FDA requires that any potential drug trial has to have a disease or condition it treats. Because aging hasn’t been seen as a disease or medical condition, no drug trials have been allowed to go forward to treat it. NONE! Finally, late last year, aging has been OFFICIALLY recognized as a disease and is therefor now a valid target disease for drug trials. **sigh**.

Are we one step closer to developing compounds that can extend our lifespan?

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