Lifeboat Foundation

Researchers have developed a new technique to produce a 3D ‘micro-printed’ array of needles capable of drug delivery. The technique would offer a pain-free drug delivery device that would allow drugs to diffuse within the body as the biomaterial device degrades in the body. This offers treatments for a wide range of diseases, including melanoma cancers.

The results are published today, Wednesday 30th September, in the journal Biofabrication .

The researchers, based at the University of Akron and the University of Texas, report producing a drug-loaded array for transdermal delivery of a chemotherapeutic drug, fabricated using microstereolithography. The arrays consisted of 25 poly(propylene fumarate) microneedles, each needle having a tip and base diameter of 20 µm and 200 µm, respectively, and a height of 1 mm.

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Visionary Liz Parrish shares some of the remarkable ways that genetic therapies are helping humanity transcend disease, aging and physical limitations. We discuss some of the current applications of gene therapy, what we can reasonably expect given the rate of progress and some of the moral implications of this science. If you’re anything like us, you’ll be astounded to hear about this work; it can already make you stronger and faster, and it may help future generations live upwards of 400 years!

Click to download the episode directly (right click, then click save as) Subscribe to the podcast on iTunes. Subscribe to the podcast on Stitcher.

“Known as “the woman who wants to genetically engineer you,” Elizabeth Parrish is the CEO of BioViva USA Inc ™ she is a humanitarian, entrepreneur and innovator and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of gene therapy, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and sits on the board of the International Longevity Alliance (ILA). She is an affiliated member of the Complex Biological Systems Alliance (CBSA) whose mission is to further scientific understanding of biological complexity and the nature and origins of human disease. She is the founder of BioTrove Investments LLC and the BioTrove Podcasts which is committed to offering a meaningful way for people to learn about and fund research in regenerative medicine. She is also the Secretary of the American Longevity Alliance (ALA) a 501©(3) nonprofit trade association that brings together individuals, companies, and organizations who work in advancing the emerging field of cellular & regenerative medicine with the aim to get governments to consider aging a disease.” –Blurb taken from Liz’ LinkedIn Profile.

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A new hydrogel protects stem cells inside the body, making existing therapies a lot more effective.

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Scientists believe they have found a better pair of molecular scissors to use with the genome-editing technique that is revolutionizing biology.

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CRISPR-Cpf1 offers simpler approach to editing DNA; technology could disrupt scientific and commercial landscape.

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Prevalence of Self-Reported Obesity Among U.S. Adults by State and Territory, BRFSS, 2014 (credit: Behavorial Risk Factor Surveillance System/CDC)

A molecule known as MnTBAP has rapidly reversed obesity in mice and could be effective for humans in the future, according to researchers from Skidmore College and the Perelman School of Medicine at the University of Pennsylvania.

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A paraplegic man who was paralysed for five years has walked again on his own two feet, thanks to a new kind of brain-computer interface that can reroute his thoughts to his legs, bypassing his spinal cord entirely.

The anonymous man, who experiences complete paralysis in both legs due to a severe spinal cord injury (SCI), is the first such patient to demonstrate that brain-controlled overground walking after paraplegia due to SCI is feasible.

Continue reading “Watch: Paralysed man walks again via brain waves rerouted to his legs” »

The past few years have been marked by the proliferation of lab-grown organs, including limbs, livers, skin, heart tissue, and yep, even penises. But piecing together an organ, cell-by-cell, in a way that resembles the real thing is only half the challenge — you’ve actually got to make it work as part of several incredibly complex systems in a living, breathing organism. And that’s where most attempts fall flat.

But researchers in Japan have managed to grow fully functioning kidneys in the lab, and when transplanted into pigs and rats, they filtered out urine just like a natural kidney. Built using stem cells that had been extracted and then incubated in the animal recipients, the kidneys point to the possibility of lab-grown kidneys for humans in the future.

Led by Takashi Yokoo from the Jikei University School of Medicine in Tokyo, the team figured out how to overcome a challenge they’d faced previously with these lab-grown kidneys: they were good at processing urine, but instead of passing it into the natural ureter, they ballooned dangerously under the pressure.

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